EFFECT OF VENOUS STASIS AND MUSCULAR EXERCISE ON TOTAL SERUM-CALCIUM CONCENTRATION

The Lancet ◽  
1962 ◽  
Vol 280 (7268) ◽  
pp. 1249-1251 ◽  
Author(s):  
F.J. Radcliff ◽  
P.E. Baume ◽  
W.O. Jones
Keyword(s):  
Serum Calcium ◽  
Calcium Concentration ◽  
Muscular Exercise ◽  
Venous Stasis ◽  
Total Serum ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium

A Membrane Ultrafiltration Procedure for Determining Diffusible Calcium in Serum

1970 ◽  
Vol 16 (3) ◽  
pp. 226-228 ◽  
Author(s):  
Genevieve Farese ◽  
Milton Mager ◽  
William F Blatt
Keyword(s):  
Serum Calcium ◽  
Calcium Concentration ◽  
Simple Procedure ◽  
Total Serum ◽  
High Flux ◽  
Ultrafiltration Membranes ◽  
Serum Calcium Concentration ◽  
Normal Value ◽  
Total Serum Calcium ◽  
The Mean

Abstract A rapid, simple procedure is described for separating diffusible from proteinbound serum calcium by centrifugation through high-flux ultrafiltration membranes. The mean normal value for ultrafilterable calcium was 57.1% (range 52 to 61%) of the total serum calcium concentration.

scholarly journals Restless legs syndrome in patients with distal diabetic polyneuropathy

2018 ◽  
Vol 146 (9-10) ◽  
pp. 512-515 ◽  
Author(s):  
Tatjana Smiljkovic ◽  
Svetlana Kostic-Dedic ◽  
Vesna Nikolic ◽  
Andjela Gavrilovic ◽  
Sanja Jevdjic
Keyword(s):  
Risk Factors ◽  
Serum Calcium ◽  
Restless Legs Syndrome ◽  
Calcium Concentration ◽  
Diabetic Polyneuropathy ◽  
Total Serum ◽  
Serum Calcium Concentration ◽  
Restless Legs ◽  
Total Serum Calcium ◽  
Distal Symmetrical Polyneuropathy

Introduction/Objective. An association between restless legs syndrome (RLS) and etiologically different polyneuropathies is well established. However, the investigations about the prevalence of RLS in diabetic polyneuropathy (DP) have led to controversy. Our study objective was to determine the frequency of RLS in patients with distal symmetrical polyneuropathy in patients with diabetes and identify possible risk factors for its occurrence in this group of patients. Method. We investigated 101 consecutive patients with distal DP. RLS was diagnosed according to the International RLS Study Group diagnostic criteria. The distal symmetrical polyneuropathy was confirmed by the electromyoneurographic study performed in each patient. Results. Overall RLS was present in 27 (26.73%) patients. The comparison between patients with and without RLS revealed that the RLS+ group included more women than men (14.85/9.90% vs. 35.64/37.62%, non-significant), patients were significantly younger (60.58 ? 10.54 vs. 65.57 ? 10.94 years, p ? 0.05), sensory polyneuropathy was significantly more common (17/27 vs. 34/74, p ? 0.05); the average level of the total serum calcium concentration was higher in the RLS + group than in non-RLS (2.43 ? 0.26 vs. 2.28 ? 0.39; p ? 0.05). However, multivariate logistic regression analysis did not demonstrate these as significant independent risk factors for RLS in DP. Conclusions. RLS is common in DP and occurs in more than a quarter of these patients. Though sensory forms and higher total serum calcium concentration were associated with RLS, neither of these has been identified as a significant single risk factor for the development of RLS in DP.

scholarly journals Predictive Value of Derived Calcium Figures Based on the Measurement of Ionised Calcium

1981 ◽  
Vol 18 (2) ◽  
pp. 106-109 ◽  
Author(s):  
Mary D Gardner ◽  
Frances J Dryburgh ◽  
J A Fyffe ◽  
A S Jenkins
Keyword(s):  
Serum Calcium ◽  
Predictive Value ◽  
Calcium Concentration ◽  
Clinical Usefulness ◽  
Total Serum ◽  
Predictive Values ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Ionised Calcium ◽  
Calcium Status

The algorithms used in this hospital to assess calcium status are calculated ionised serum calcium and the serum calcium concentration adjusted for albumin. In order to establish their clinical usefulness, they were compared with the ionised calcium concentration measured on the Nova 2 instrument in patients with various calcium and protein abnormalities. Good correlation was found between the measured and calculated values. The predictive values for the calculated results and for total serum calcium concentrations are presented. In this series, the derived values were useful in predicting the serum ionised calcium concentration of the patients studied.

Neurologic Sequelae Associated with Foscarnet Therapy

1994 ◽  
Vol 28 (9) ◽  
pp. 1035-1037 ◽  
Author(s):  
Edward Lor ◽  
Yong Qing Liu
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Calcium Concentration ◽  
Total Serum ◽  
Cns Involvement ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Neurologic Sequelae ◽  
History Of ◽  
Cns Lesions

OBJECTIVE: To report three cases of possible foscarnet-induced neurologic sequelae. CASE SUMMARY: We report two cases of seizures and one case of hand cramping and finger paresthesia after starting foscarnet therapy with no evidence of predisposing risk factors, such as serum laboratory abnormalities, renal dysfunction, or known central nervous system (CNS) involvement. All three patients had stable laboratory values during therapy and when the neurologic adverse effects occurred. All patients were receiving appropriate dosages of foscarnet. DISCUSSION: The incidence of seizures in AIDS patients was reviewed. A history of CNS lesions, infections, and/or AIDS per se may increase the risk of a neurologic adverse effect while receiving foscarnet therapy. Acute ionized hypocalcemia may cause these neurologic adverse effects. Ionized hypocalcemia is transitory, is related to the rate of foscarnet infusion, and may not be reflected as a change in total serum calcium concentration. CONCLUSIONS: Foscarnet probably contributed to the neurologic adverse effects reported here. Foscarnet may need to be administered at a slower rate than is recommended by the manufacturer. Electrolytes must be monitored closely; however, a neurologic adverse effect may not be foreseen.

Serum ionized calcium and corrected total calcium in borderline hyperparathyroidism.

1978 ◽  
Vol 24 (11) ◽  
pp. 1962-1965 ◽  
Author(s):  
L Larsson ◽  
S Ohman
Keyword(s):  
Serum Calcium ◽  
Reference Range ◽  
Reference Group ◽  
Ionized Calcium ◽  
Total Serum ◽  
Albumin Concentration ◽  
Serum Calcium Concentration ◽  
Normal Limits ◽  
Total Serum Calcium ◽  
Serum Ionized Calcium

Abstract We studied 25 borderline-hyperparathyroidism patients whose total serum calcium concentration was within normal limits (reference range: 2.25--2.75 mmol/liter) but whose concentrations of serum ionized calcium were above normal (reference range: 1.03--1.23 mmol/liter). Their hyperparathyroidism was histopathologically verified. To compare the discriminating value of corrected serum calcium with ionized calcium, we studied the serum calcium and albumin concentrations in a reference group of 2098 patients. After patients from endocrine and dialysis departments were excluded from the reference group, we obtained the range (mean +/- 2 SD) 2.05--2.71 mmol/liter for uncorrected serum calcium and 2.11--2.63 mmol/liter for corrected serum calcium. The correction factor for calcium on albumin was 20 mumol/g. Even with this limit for corrected serum calcium, 13 of 25 borderline hyperparathyroidism patients had values that fell within the reference range. We conclude that correcting total serum calcium values for serum albumin concentration improves discrimination of borderline hyperparathyroid patients, but that measurement of ionized calcium in serum discriminates better.

Evaluation of an Automatic Calcium Titrator

1971 ◽  
Vol 17 (12) ◽  
pp. 1171-1175 ◽  
Author(s):  
Roy L Alexander
Keyword(s):  
Calcium Concentration ◽  
Chelating Agent ◽  
Atomic Absorption Spectrophotometry ◽  
Total Serum ◽  
Tetraacetic Acid ◽  
Digital Readout ◽  
Serum Calcium Concentration ◽  
Analytical Technique ◽  
Absorption Spectrophotometry ◽  
Total Serum Calcium

Abstract An automatic calcium titrator for determining total serum calcium concentration has been evaluated. The instrument incorporates a motorized buret, a fluorometer, and a digital readout that is responsive to the quenching of the fluorescent calcium—calcein complex by the chelating agent, ethyleneglycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid. Analyses made with the calcium titrator were compared with those made with the SMA 12/60 and atomic absorption spectrophotometry. Good correlation was obtained in each instance. Slight hemolysis and bilirubin concentrations near normal did not affect the results; however, increased concentrations of these substances resulted in decreased values. The precision of analysis depends on the technique used in pipetting the sample. A single analysis of 0.1 ml of serum can be completed in 1 to 2 min. With careful analytical technique, precision is good (CV, 0.72%).

Influence of serum Ca concentration on circulating molecular forms of PTH in three species

1986 ◽  
Vol 251 (6) ◽  
pp. E680-E687 ◽  
Author(s):  
P. D'Amour ◽  
F. Labelle ◽  
L. Lecavalier ◽  
V. Plourde ◽  
D. Harvey
Keyword(s):  
Serum Calcium ◽  
Calcium Concentration ◽  
Molecular Forms ◽  
Total Serum ◽  
Gel Chromatography ◽  
Intact Pth ◽  
Serum Calcium Concentration ◽  
Serum Pth ◽  
Bovine Species ◽  
Peripheral Metabolism

The influence of serum calcium concentration on total circulating parathyroid hormone (PTH) and on the relative amount of intact PTH-(1-84) and large carboxyterminal fragments was studied in the canine and bovine species and in man. Serum calcium was modified through infusions of CaCl2 or EDTA and samples obtained in time for the measurement of serum calcium and PTH concentrations. Pools of serum, corresponding to specific serum calcium concentrations, were analyzed by gel chromatography in all species. PTH was measured with a carboxyterminal radioimmunoassay. In basal conditions, total serum PTH was composed mostly of large carboxyterminal fragments, intact PTH-(1-84) representing less than 25% of the hormone in any species. With hypercalcemia, (greater than or equal to 2.0 mg/dl), total serum PTH decreased only to 40% of the original value measured in all species, despite serum calcium concentrations of over 13 mg/dl. The relative amount of intact PTH-(1-84) remained unchanged in the bovine and canine species and slightly decreased in man. Hypocalcemia (less than or equal to 2.0 mg/dl) induced a 300-450% increase in the basal PTH value measured. The relative amount of intact PTH-(1-84) became as or more important than carboxyterminal fragments in the canine species and in man, respectively, and remained slightly less in the bovine species. Despite small quantitative variations between species, these results indicate that changes in serum calcium concentration induced acute modification in PTH secretion or PTH peripheral metabolism, altering the ratio of intact hormone to carboxyterminal fragments in circulation.

scholarly journals Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery

2015 ◽  
Vol 172 (5) ◽  
pp. 527-535 ◽  
Author(s):  
Aliya Khan ◽  
John Bilezikian ◽  
Henry Bone ◽  
Andrey Gurevich ◽  
Peter Lakatos ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Controlled Study ◽  
Total Serum ◽  
Open Label ◽  
Double Blind ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Normal Mean ◽  
Serum Pth

ObjectivePrimary hyperparathyroidism (PHPT) is diagnosed by the presence of hypercalcemia and elevated or nonsuppressed parathyroid hormone (PTH) levels. Although surgery is usually curative, some individuals fail or are unable or unwilling to undergo parathyroidectomy. In such individuals, targeted medical therapy may be of value. Cinacalcet normalized calcium level and lowered PTH in patients with PHPT in several phase 2 and open-label studies. We compared cinacalcet and placebo in subjects with PHPT unable to undergo parathyroidectomy.DesignPhase 3, double-blind, multi centere, randomized, placebo-controlled study.MethodsSixty-seven subjects (78% women) with moderate PHPT were randomized (1:1) to cinacalcet or placebo for ≤28 weeks.Main outcome measureAchievement of a normal mean corrected total serum calcium concentration of ≤10.3 mg/dl (2.575 mmol/l).ResultsBaseline median (quartile 1 (Q1), Q3) serum PTH was 164.0 (131.0, 211.0) pg/ml and mean (s.d.) serum Ca was 11.77 (0.46) mg/dl. Serum Ca normalized (≤10.3 mg/dl) in 75.8% of cinacalcet- vs 0% of placebo-treated subjects (P<0.001). Corrected serum Ca decreased by ≥1.0 mg/dl from baseline in 84.8% of cinacalcet- vs 5.9% of placebo-treated subjects (P<0.001). Least squares mean (s.e.m.) plasma PTH change from baseline was −23.80% (4.18%) (cinacalcet) vs −1.01% (4.05%) (placebo) (P<0.001). Similar numbers of subjects in the cinacalcet and placebo groups reported adverse events (AEs) (27 vs 20) and serious AEs (three vs four). Most commonly reported AEs were nausea and muscle spasms.ConclusionsThese results demonstrate that cinacalcet normalizes serum calcium in this PHPT population and appears to be well tolerated.

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