Neurologic Sequelae Associated with Foscarnet Therapy

1994 ◽  
Vol 28 (9) ◽  
pp. 1035-1037 ◽  
Author(s):  
Edward Lor ◽  
Yong Qing Liu
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Calcium Concentration ◽  
Total Serum ◽  
Cns Involvement ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Neurologic Sequelae ◽  
History Of ◽  
Cns Lesions

OBJECTIVE: To report three cases of possible foscarnet-induced neurologic sequelae. CASE SUMMARY: We report two cases of seizures and one case of hand cramping and finger paresthesia after starting foscarnet therapy with no evidence of predisposing risk factors, such as serum laboratory abnormalities, renal dysfunction, or known central nervous system (CNS) involvement. All three patients had stable laboratory values during therapy and when the neurologic adverse effects occurred. All patients were receiving appropriate dosages of foscarnet. DISCUSSION: The incidence of seizures in AIDS patients was reviewed. A history of CNS lesions, infections, and/or AIDS per se may increase the risk of a neurologic adverse effect while receiving foscarnet therapy. Acute ionized hypocalcemia may cause these neurologic adverse effects. Ionized hypocalcemia is transitory, is related to the rate of foscarnet infusion, and may not be reflected as a change in total serum calcium concentration. CONCLUSIONS: Foscarnet probably contributed to the neurologic adverse effects reported here. Foscarnet may need to be administered at a slower rate than is recommended by the manufacturer. Electrolytes must be monitored closely; however, a neurologic adverse effect may not be foreseen.

A Membrane Ultrafiltration Procedure for Determining Diffusible Calcium in Serum

1970 ◽  
Vol 16 (3) ◽  
pp. 226-228 ◽  
Author(s):  
Genevieve Farese ◽  
Milton Mager ◽  
William F Blatt
Keyword(s):  
Serum Calcium ◽  
Calcium Concentration ◽  
Simple Procedure ◽  
Total Serum ◽  
High Flux ◽  
Ultrafiltration Membranes ◽  
Serum Calcium Concentration ◽  
Normal Value ◽  
Total Serum Calcium ◽  
The Mean

Abstract A rapid, simple procedure is described for separating diffusible from proteinbound serum calcium by centrifugation through high-flux ultrafiltration membranes. The mean normal value for ultrafilterable calcium was 57.1% (range 52 to 61%) of the total serum calcium concentration.

scholarly journals Restless legs syndrome in patients with distal diabetic polyneuropathy

2018 ◽  
Vol 146 (9-10) ◽  
pp. 512-515 ◽  
Author(s):  
Tatjana Smiljkovic ◽  
Svetlana Kostic-Dedic ◽  
Vesna Nikolic ◽  
Andjela Gavrilovic ◽  
Sanja Jevdjic
Keyword(s):  
Risk Factors ◽  
Serum Calcium ◽  
Restless Legs Syndrome ◽  
Calcium Concentration ◽  
Diabetic Polyneuropathy ◽  
Total Serum ◽  
Serum Calcium Concentration ◽  
Restless Legs ◽  
Total Serum Calcium ◽  
Distal Symmetrical Polyneuropathy

Introduction/Objective. An association between restless legs syndrome (RLS) and etiologically different polyneuropathies is well established. However, the investigations about the prevalence of RLS in diabetic polyneuropathy (DP) have led to controversy. Our study objective was to determine the frequency of RLS in patients with distal symmetrical polyneuropathy in patients with diabetes and identify possible risk factors for its occurrence in this group of patients. Method. We investigated 101 consecutive patients with distal DP. RLS was diagnosed according to the International RLS Study Group diagnostic criteria. The distal symmetrical polyneuropathy was confirmed by the electromyoneurographic study performed in each patient. Results. Overall RLS was present in 27 (26.73%) patients. The comparison between patients with and without RLS revealed that the RLS+ group included more women than men (14.85/9.90% vs. 35.64/37.62%, non-significant), patients were significantly younger (60.58 ? 10.54 vs. 65.57 ? 10.94 years, p ? 0.05), sensory polyneuropathy was significantly more common (17/27 vs. 34/74, p ? 0.05); the average level of the total serum calcium concentration was higher in the RLS + group than in non-RLS (2.43 ? 0.26 vs. 2.28 ? 0.39; p ? 0.05). However, multivariate logistic regression analysis did not demonstrate these as significant independent risk factors for RLS in DP. Conclusions. RLS is common in DP and occurs in more than a quarter of these patients. Though sensory forms and higher total serum calcium concentration were associated with RLS, neither of these has been identified as a significant single risk factor for the development of RLS in DP.

Evaluation of an Automatic Calcium Titrator

1971 ◽  
Vol 17 (12) ◽  
pp. 1171-1175 ◽  
Author(s):  
Roy L Alexander
Keyword(s):  
Calcium Concentration ◽  
Chelating Agent ◽  
Atomic Absorption Spectrophotometry ◽  
Total Serum ◽  
Tetraacetic Acid ◽  
Digital Readout ◽  
Serum Calcium Concentration ◽  
Analytical Technique ◽  
Absorption Spectrophotometry ◽  
Total Serum Calcium

Abstract An automatic calcium titrator for determining total serum calcium concentration has been evaluated. The instrument incorporates a motorized buret, a fluorometer, and a digital readout that is responsive to the quenching of the fluorescent calcium—calcein complex by the chelating agent, ethyleneglycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid. Analyses made with the calcium titrator were compared with those made with the SMA 12/60 and atomic absorption spectrophotometry. Good correlation was obtained in each instance. Slight hemolysis and bilirubin concentrations near normal did not affect the results; however, increased concentrations of these substances resulted in decreased values. The precision of analysis depends on the technique used in pipetting the sample. A single analysis of 0.1 ml of serum can be completed in 1 to 2 min. With careful analytical technique, precision is good (CV, 0.72%).

scholarly journals Predictive Value of Derived Calcium Figures Based on the Measurement of Ionised Calcium

1981 ◽  
Vol 18 (2) ◽  
pp. 106-109 ◽  
Author(s):  
Mary D Gardner ◽  
Frances J Dryburgh ◽  
J A Fyffe ◽  
A S Jenkins
Keyword(s):  
Serum Calcium ◽  
Predictive Value ◽  
Calcium Concentration ◽  
Clinical Usefulness ◽  
Total Serum ◽  
Predictive Values ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Ionised Calcium ◽  
Calcium Status

The algorithms used in this hospital to assess calcium status are calculated ionised serum calcium and the serum calcium concentration adjusted for albumin. In order to establish their clinical usefulness, they were compared with the ionised calcium concentration measured on the Nova 2 instrument in patients with various calcium and protein abnormalities. Good correlation was found between the measured and calculated values. The predictive values for the calculated results and for total serum calcium concentrations are presented. In this series, the derived values were useful in predicting the serum ionised calcium concentration of the patients studied.

Acute Dystonic Reaction to Methotrimeprazine in Hypoparathyroidism

1996 ◽  
Vol 30 (9) ◽  
pp. 957-959 ◽  
Author(s):  
Hanan Gur ◽  
Yoav Paz ◽  
Yechezkel Sidi
Keyword(s):  
Adverse Effects ◽  
Serum Calcium ◽  
Calcium Concentration ◽  
Antipsychotic Drugs ◽  
Combined Effects ◽  
Serum Calcium Concentration ◽  
Dystonic Reaction ◽  
Case Summary ◽  
Adenylate Cyclase Activation ◽  
Increased Sensitivity

OBJECTTVE: To report a case of acute dystonic reaction to methotrimeprazine in a patient with untreated hypoparathyroidism, emphasizing the potential increased sensitivity of hypocalcemic patients to the extrapyramidal adverse effects of antipsychotic drugs. CASE SUMMARY: An 80-year-old man who had untreated hypoparathyroidism and chronic hypocalcemia developed an acute dystonic reaction 20 minutes after ingestion of methotrimeprazine 25 mg. His medical history included an ill-defined psychiatric disorder for which he had been treated with methotrimeprazine several years earlier. The patient denied having any other diseases or taking any other medications. After 4 days, the disorientation, psychomotor restlessness, dystonic grimacing, protrusion of the tongue, and speech difficulties disappeared, despite a remaining low serum calcium concentration. DISCUSSION: A possible mechanism, by which striatal calmodulin-mediated adenylate cyclase activation is inhibited by the combined effects of phenothiazines and hypocalcemia, is discussed. CONCLUSIONS: In this patient, it is not possible to ascertain whether the dystonic reaction was due to hypocalcemia, phenothiazine administration, or both. However, it is suggested that patients with hypocalcemia may be sensitive to the extrapyramidal adverse effects of antipsychotics. In addition, acute unexpected dystonic reactions to a small dose of antipsychotics warrants measurement of the patient's serum calcium concentration.

Secretion of calcium by rat submandibular gland

1959 ◽  
Vol 196 (3) ◽  
pp. 645-648 ◽  
Author(s):  
Robert H. Dreisbach
Keyword(s):  
Submandibular Gland ◽  
Calcium Concentration ◽  
Total Serum ◽  
Transient Phase ◽  
Secretory Rate ◽  
Total Serum Calcium ◽  
The Mean ◽  
Rat Submandibular Gland ◽  
Calcium Loss ◽  
Mean Concentration

The mean concentration of calcium in rat submandibular gland saliva after maximal pilocarpine stimulation was initially 3.2 µEq/gm and gradually fell during the 1st hour to 0.93 µEq/gm. The final concentration was approximately 30% of the concentration of calcium in the serum ultrafiltrate whether the total serum calcium was normal or elevated threefold by the infusion of calcium chloride. At the end of the transient phase, the gland calcium concentration was from 28 to 57% less than the initial gland concentration depending upon the type of anesthesia used. The calcium loss from the gland correlated well with the excess calcium secreted in the saliva during the transient phase. After the initial transient phase was ended, the saliva calcium concentration bore an inverse relationship to the secretory rate and was directly proportional to the serum ultrafiltrate calcium concentration.

scholarly journals Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?

2020 ◽  
Vol 10 (4) ◽  
pp. 0343
Author(s):  
Virgínia M. Bolina ◽  
Thays S. Mendonça ◽  
Mariana L. Pereira ◽  
Caroline P. Domingueti ◽  
João P. Rodrigues ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Adverse Events ◽  
Health System ◽  
Liver Enzymes ◽  
Public Health System ◽  
Fasting Glucose ◽  
Total Serum ◽  
Total Serum Calcium ◽  
Chronic Use

Introduction: chronic use of corticosteroids can trigger several adverse effects with changes in glycemic, lipid, liver enzymes and electrolyte levels. Therefore, the the aim of the present study was to analyze if the patients on chronic prednisone use from the Brazilian Public Health System (PHS) in a Midwestern municipality of the state of Minas Gerais were monitored for their adverse effects through laboratory tests. Methods: a longitudinal descriptive study was carried out with retrospective data from patients attended by the PHS of this city, and who have used prednisone chronically for three consecutive years, from 2014 to 2016. The frequency of patients who underwent tests to monitor adverse events from the chronic use of prednisone was verified through electronic records in the Integrated Health System (IHS). The following types of tests were analyzed: total serum calcium, urine calcium (24-hour urine), serum phosphate, alkaline phosphatase, fasting glucose, sodium (Na+), potassium (K+), and lipidogram (triglycerides, LDL, VLDL, HDL, and total cholesterol). Results: it was observed that fasting glucose and lipidogram were the tests that presented the highest number of annual records. However, for the other examined parameters, which are essential for the follow-up of patients in chronic use of corticosteroids, the non-monitoring index is greater than 80 %. Conclusions: the results revealed an inadequate frequency of laboratory monitoring of patients in chronic prednisone use, indicating the occurrence of prescriptions without the monitoring of possible adverse effects, which may constitute safety problems for patients.

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