Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery

Placenta ◽  
1997 ◽  
Vol 18 (4) ◽  
pp. 269-276 ◽  
Author(s):  
F. Lyall ◽  
A. Young ◽  
F. Boswell ◽  
J.C.P. Kingdom ◽  
I.A. Greer
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Vascular Endothelial ◽  
Intrauterine Growth ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor and Placenta Growth Factor in Intrauterine Growth-Restricted Fetuses and Neonates

2005 ◽  
Vol 2005 (5) ◽  
pp. 293-297 ◽  
Author(s):  
Ariadne Malamitsi-Puchner ◽  
Theodora Boutsikou ◽  
Emmanuel Economou ◽  
Angeliki Sarandakou ◽  
Evangelos Makrakis ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Intrauterine Growth Restriction ◽  
Vascular Endothelial ◽  
Placenta Growth Factor ◽  
Placental Function ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
Endothelial Growth Factor ◽  
Circulating Levels

The angiogenic factors vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) are respectively up- and downregulated by hypoxia. We aimed to study circulating levels of the above factors in intrauterine growth restriction (IUGR) and to correlate their levels with the customized centiles of the infants. The study included 25 IUGR and 25 appropriate for gestational age (AGA) full-term, singleton infants and their mothers. Maternal (MS), fetal (UC), and neonatal day 1 (N1) and 4 (N4) blood was examined. MS and N1 PlGF, as well as UC VEGF levels correlated with the customized centiles of the infants (r=0.39,P=.007,r=0.34,P=.01, andr=−0.41,P=.004, resp). Furthermore, UC, N1, and N4 VEGF levels were higher in girls (r=0.36,P=.01,r=0.33,P=.02, andr=0.41,P=.005resp). In conclusion, positive and negative correlations of examined factors with the customized centiles of the infant could rely on placental function and intrauterine oxygen concentrations—both being usually lower in IUGR cases—while higher VEGF levels in girls should possibly be attributed to the stimulating action of estrogens.

scholarly journals A legjelentősebb angiogeneticus gének méhlepényi expressziójának változásai a méhen belüli növekedési visszamaradás hátterében

2017 ◽  
Vol 158 (16) ◽  
pp. 612-617
Author(s):  
Péter Kovács ◽  
Attila Rab ◽  
Imre Szentpéteri ◽  
József Gábor Joó ◽  
László Kornya
Keyword(s):  
Growth Factor ◽  
Intrauterine Growth Restriction ◽  
Vascular Dysfunction ◽  
Maternal Serum ◽  
Growth Restriction ◽  
Compensatory Mechanism ◽  
Vascular Endothelial ◽  
Intrauterine Growth ◽  
Placental Blood ◽  
Endothelial Growth Factor

Abstract: Placental vascular endothelial growth factor A (VEGF-A) gene and endoglin gene are both overexpressed in placental samples obtained from pregnancies with intrauterine growth restriction compared to normal pregnancies. In the background of these changes a mechanism can be supposed, in which the increased endoglin activity in intrauterine growth restriction (IUGR) leads to impaired placental circulation through an antioangiogenetic effect. This results in the development of placental vascular dysfunction and chronic fetal hypoxia. It is chronic hypoxia that turns on VEGF-A as a compensatory mechanism to improve fetal vascular blood supply by promoting placental blood vessel formation. Although the maternal serum placental growth factor (PlGF) level is a potential predictor for both IUGR and praeeclampsia, placental PlGF gene activity may be less of an active in the regulation of placental circulation in IUGR pregnancies during the later stages of gestation. Orv. Hetil., 2017, 158(16), 612–617.

Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates

2006 ◽  
Vol 82 (4) ◽  
pp. 235-239 ◽  
Author(s):  
Theodora Boutsikou ◽  
Ariadne Malamitsi-Puchner ◽  
Emmanuel Economou ◽  
Maria Boutsikou ◽  
Karl-Philipp Puchner ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Intrauterine Growth ◽  
Endothelial Growth Factor
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