Age-related changes in the regional variations in the number and subsets of intraepithelial lymphocytes in mouse small intestine

2002 ◽  
Vol 26 (6) ◽  
pp. 589-595 ◽  
Author(s):  
Hodaka Suzuki ◽  
Kwang Il Jeong ◽  
Kunio Doi
Keyword(s):  
Small Intestine ◽  
Intraepithelial Lymphocytes ◽  
Regional Variations ◽  
Age Related ◽  
Mouse Small Intestine ◽  
Age Related Changes

scholarly journals A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Yu-Xuan Lu ◽  
Jennifer C Regan ◽  
Jacqueline Eßer ◽  
Lisa F Drews ◽  
Thomas Weinseis ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Small Intestine ◽  
Chromatin Organization ◽  
Healthy Longevity ◽  
Age Related ◽  
Elevated Expression ◽  
Chromatin Organisation ◽  
Multicellular Organisms ◽  
Intestinal Enterocytes ◽  
Age Related Changes

Age-related changes to histone levels are seen in many species. However, it is unclear whether changes to histone expression could be exploited to ameliorate the effects of ageing in multicellular organisms. Here we show that inhibition of mTORC1 by the lifespan-extending drug rapamycin increases expression of histones H3 and H4 post-transcriptionally, through eIF3-mediated translation. Elevated expression of H3/H4 in intestinal enterocytes in Drosophila alters chromatin organization, induces intestinal autophagy through transcriptional regulation, prevents age-related decline in the intestine. Importantly, it also mediates rapamycin-induced longevity and intestinal health. Histones H3/H4 regulate expression of an autophagy cargo adaptor Bchs (WDFY3 in mammals), increased expression of which in enterocytes mediates increased H3/H4-dependent healthy longevity. In mice, rapamycin treatment increases expression of histone proteins and Wdfy3 transcription, and alters chromatin organisation in the small intestine, suggesting the mTORC1-histone axis is at least partially conserved in mammals and may offer new targets for anti-ageing interventions.

Age-related changes in the distribution and frequency of myeloid and T cell populations in the small intestine of calves

2011 ◽  
Vol 271 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Patrick N. Fries ◽  
Yurij I. Popowych ◽  
Le Luo Guan ◽  
Philip J. Griebel
Keyword(s):  
Small Intestine ◽  
T Cell ◽  
Cell Populations ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine

2011 ◽  
Vol 7 (2) ◽  
pp. 197-207 ◽  
Author(s):  
Artur Pałasz ◽  
Anna Wiaderkiewicz ◽  
Ryszard Wiaderkiewicz ◽  
Piotr Czekaj ◽  
Beata Czajkowska ◽  
...  
Keyword(s):  
Small Intestine ◽  
Mrna Levels ◽  
Rat Small Intestine ◽  
Age Related ◽  
Age Related Changes
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