First trimester screening for aneuploidy: Serum biochemical markers

1999 ◽  
Vol 23 (5) ◽  
pp. 359-368 ◽  
Author(s):  
Jacob A. Canick ◽  
Leonard H. Kellner
Keyword(s):  
Biochemical Markers ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Serum Biochemical

First-trimester screening for Down syndrome in France combining fetal nuchal translucency measurement and biochemical markers

2003 ◽  
Vol 23 (10) ◽  
pp. 833-836 ◽  
Author(s):  
Fran�oise Muller ◽  
Clarisse Benattar ◽  
Fran�ois Audibert ◽  
Nathalie Roussel ◽  
Sophie Dreux ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Biochemical Markers ◽  
First Trimester ◽  
Nuchal Translucency ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Nuchal Translucency Measurement

Distribution of Biochemical and Ultrasound Markers Values in the First Trimester Screening Program in Timisoara

2017 ◽  
Vol 68 (7) ◽  
pp. 1636-1639
Author(s):  
Dan Navolan ◽  
Simona Vladareanu ◽  
Ioana Ciohat ◽  
Adrian Carabineanu ◽  
Marius Craina ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
Screening Program ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ultrasound Measurement ◽  
First Trimester Screening ◽  
Disturbing Factor ◽  
Trimester Screening

The aim of our study was to analyze the distribution of biochemical markers (free-� hCG and PAPP-A) and nuchal translucency (NT) values and their deviation from expected median in our screening program. NT, free-� hCG and PAPP-A values were measured in first trimester sera of 1313 singleton pregnant women. The age (mean �standard deviation) of pregnant women at the time of screening was 28.94�4.95 years and the gestational age was 87.66�4.74 days. The value of NT (median�standard error of mean) was 0.87�0.01 multiple of median corrected (MoMc), of free-b hCG was 1.07�0.02 MoMc and of PAPP-A was 1.06�0.01 MoMc. Since the huge majority of pregnant women carried a healthy fetus it was assumed that the median value of measurements was equal to 1 MoMc and the deviation from median was equal to null. Our results showed that the greatest deviation from the expected median (-0.13 MoMc) was recorded for the NT measurement while the deviation for the free-� hCG and PAPP-A values was 0.07 respectively 0.06. In conclusion the main disturbing factor in calculating the aneuploidy risk was the measurement of NT. A systematic audit of laboratory and ultrasound measurement is necessary.

The Effect of Chemical Compounds from Cigarettes Smoke on First Trimester Biochemical Markers

2017 ◽  
Vol 68 (9) ◽  
pp. 2122-2124
Author(s):  
Adrian Carabineanu ◽  
Dan Navolan ◽  
Florin Birsasteanu ◽  
Octavian Cretu ◽  
Marioara Boia ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Biochemical Markers ◽  
Protein A ◽  
Chemical Compounds ◽  
First Trimester ◽  
Physical Parameters ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
The Relationship

Previous studies showed that certain behavioral and physical parameters influence the concentration of first trimester biochemical markers. The scope of the present article was to study the relationship between smoking and first trimester screening biochemical markers and the capability of the software to counterbalance this influence. Concentrations of pregnancy-associated protein A (PAPP-A) and free b chorionic gonadotropin hormone (free b hCG) were measured in sera of 1554 first trimester pregnant women, 1349 of which were non-smokers and 205 were smokers. First trimester PAPP-A values are lower in smoking compared to non-smoking pregnant women (0.94�0.04 vs. 1.09�0.02, p=0.0004), since smoking seems not to influence free b hCG concentration (1.11�0.07 vs. 1.03�0.02, ns). The software used by us corrected successfully the effect of chemical compounds from cigarette smoke on PAPP-A values.

Trends in early prenatal screening for chromosomal abnormalities and congenital malformations in Russia in 2018

2020 ◽  
pp. 76-78
Author(s):  
Е.А. Калашникова ◽  
Е.Н. Андреева ◽  
П.А. Голошубов ◽  
Н.О. Одегова ◽  
Е.В. Юдина ◽  
...  
Keyword(s):  
Reference Values ◽  
Congenital Malformations ◽  
Prenatal Screening ◽  
Chromosomal Abnormalities ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Overall Effectiveness ◽  
Regions Of Russia

В ходе анализа результатов раннего пренатального скрининга (РПС) в России за 2018 г. (Аудит-2019) дана оценка качества мероприятий, общей эффективности и тенденций развития системы РПС в субъектах РФ посредством сравнения рассчитанных основных организационных, методологических и интегральных показателей с международными референтными значениями. In the course of analyzing the results of early prenatal combined first-trimester screening (FTS) in Russia for 2018 (Audit-2019) the assessment of the quality of measures, the overall effectiveness and trends in the development of the FTS system in the regions of Russia. They are presented by comparing the calculated main organizational, methodological and integral indicators with international reference values.

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