Numerical aberrations of chromosomes 1 and 17 in tumor cell lines of the exocrine pancreas as determined by fluorescence in situ hybridization

1997 ◽  
Vol 94 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Berlinda Verdoodt ◽  
Ian Charlette ◽  
Bernard Maillet ◽  
Micheline Kirsch-Volders
1994 ◽  
Vol 77 (2) ◽  
pp. 166
Author(s):  
Jose M. Coco-Martin ◽  
Monique F.M.A. Smeets ◽  
Marilyn Poggensee ◽  
Els Mooren ◽  
Cecile Ottenheim ◽  
...  

1993 ◽  
Vol 43 (12) ◽  
pp. 730-735
Author(s):  
Naoki Yoshimi ◽  
Chiken Shibuya ◽  
Yukio Morishita ◽  
Takuji Tanaka ◽  
Hideki Mori

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1716-1722 ◽  
Author(s):  
Iwona Wlodarska ◽  
Anna Aventı́n ◽  
Júlia Inglés-Esteve ◽  
Daniela Falzetti ◽  
Arnold Criel ◽  
...  

Abstract Translocation t(5; 12)(q33; p13), resulting in an ETV6/PDGFRB gene fusion, is a recurrent chromosomal abnormality associated with chronic myelomonocytic leukemia (CMML). An analogous translocation was also found in four cell lines with features of pre-B acute lymphoblastic leukemia (ALL). Using fluorescence in situ hybridization (FISH) we show here that in three of these cell lines identical complex rearrangements occurred. However, the regions involved on 5q and 12p are different from the breakpoints in CMML, and the translocation is accompanied by seemingly identical cryptic deletions of both 5q and 12p chromosome sequences in all analyzed pre-B ALL cell lines. The similar cytogenetic, FISH, and immunophenotyping findings in the three cell lines suggest that the t(5; 12)(q31q33; p12) defines a new entity of pre-B ALL.


2013 ◽  
Vol 29 (13) ◽  
pp. i189-i198 ◽  
Author(s):  
Salim Akhter Chowdhury ◽  
Stanley E. Shackney ◽  
Kerstin Heselmeyer-Haddad ◽  
Thomas Ried ◽  
Alejandro A. Schäffer ◽  
...  

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