A Selective Process For The Synthesis of Para-Nitrophenol

Author(s):  
C. Maliverney ◽  
M.H. Gubelmann ◽  
J. Susini
Keyword(s):  
Genetics ◽  
1980 ◽  
Vol 94 (4) ◽  
pp. 989-1000
Author(s):  
Francis Minvielle

ABSTRACT A quantitative character controlled at one locus with two alleles was submitted to artificial (mass) selection and to three modes of opposing natural selection (directional selection, overdominance and underdominance) in a large random-mating population. The selection response and the limits of the selective process were studied by deterministic simulation. The lifetime of the process was generally between 20 and 100 generations and did not appear to depend on the mode of natural selection. However, depending on the values of the parameters (initial gene frequency, selection intensity, ratio of the effect of the gene to the environmental standard deviation, fitness values) the following outcomes of selection were observed: fixation of the allele favored by artificial selection, stable nontrivial equilibrium, unstable equilibrium and loss of the allele favored by artificial selection. Finally, the results of the simulation were compared to the results of selection experiments.


1994 ◽  
Vol 125 (4) ◽  
pp. 879-892 ◽  
Author(s):  
T W White ◽  
R Bruzzone ◽  
S Wolfram ◽  
D L Paul ◽  
D A Goodenough

Gap junctions are collections of intercellular channels composed of structural proteins called connexins (Cx). We have examined the functional interactions of the three rodent connexins present in the lens, Cx43, Cx46, and Cx50, by expressing them in paired Xenopus oocytes. Homotypic channels containing Cx43, Cx46, or Cx50 all developed high conductance. heterotypic channels composed of Cx46 paired with either Cx43 or Cx50 were also well coupled, whereas Cx50 did not form functional channels with Cx43. We also examined the functional response of homotypic and heterotypic channels to transjunctional voltage and cytoplasmic acidification. We show that all lens connexins exhibited sensitivity to cytoplasmic acidification as well as to voltage, and that voltage-dependent closure of heterotypic channels for a given connexin was dramatically influenced by its partner connexins in the adjacent cell. Based on the observation that Cx43 can discriminate between Cx46 and Cx50, we investigated the molecular determinants that specify compatibility by constructing chimeric connexins from portions of Cx46 and Cx50 and testing them for their ability to form channels with Cx43. When the second extracellular (E2) domain in Cx46 was replaced with the E2 of Cx50, the resulting chimera could no longer form heterotypic channels with Cx43. A reciprocal chimera, where the E2 of Cx46 was inserted into Cx50, acquired the ability to functionally interact with Cx43. Together, these results demonstrate that formation of intercellular channels is a selective process dependent on the identity of the connexins expressed in adjacent cells, and that the second extracellular domain is a determinant of heterotypic compatibility between connexins.


2020 ◽  
Vol 396 ◽  
pp. 122707
Author(s):  
Yang Dai ◽  
Zhaodong Xu ◽  
Dong Hua ◽  
Hannian Gu ◽  
Ning Wang
Keyword(s):  

1967 ◽  
Vol 20 (2) ◽  
pp. 483 ◽  
Author(s):  
KA Handreck ◽  
LH P Jones

Silica is present in soil and culture solutions as undissociated monosilicic acid (H4Si04) and this suggests that its uptake by plants would be a passive, non-selective process. We have earlier reported (Jones and Handreck 1965) that the overall uptake by oats (Avena sterilis cv. Algerian) can be accounted for simply in terms of the concentration of monosilicic acid in the soil solution and the amount of water transpired. Thus, when grown in two potted soils containing 7 and 67 p.p.m. Si02 in solution, oat plants at maturity contained 28 and 274 mg Si02 per plant respectively, having transpired 3�9 litres of water and produced 7�0 g of dry matter. The concentration of silica in xylem sap from oats is similar to that in the external solution. When Trifolium incarnatum (L.) (crimson clover) was grown in these two soils the plants had transpiration ratios of 510-530 but contained silica in concentrations which were only 5-10% of those in oats. This suggests that T. incarnatum has some means of excluding silica from the tops; we have examined this further by measuring the concentration of silica in the xylem sap.


2020 ◽  
Vol 21 (23) ◽  
pp. 9255
Author(s):  
Rita Polito ◽  
Irene Di Meo ◽  
Michelangela Barbieri ◽  
Aurora Daniele ◽  
Giuseppe Paolisso ◽  
...  

Adiponectin is an adipokine produced by adipose tissue. It has numerous beneficial effects. In particular, it improves metabolic effects and glucose homeostasis, lipid profile, and is involved in the regulation of cytokine profile and immune cell production, having anti-inflammatory and immune-regulatory effects. Adiponectin’s role is already known in immune diseases and also in neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are a set of diseases of the central nervous system, characterized by a chronic and selective process of neuron cell death, which occurs mainly in relation to oxidative stress and neuroinflammation. Lifestyle is able to influence the development of these diseases. In particular, unhealthy nutrition on gut microbiota, influences its composition and predisposition to develop many diseases such as neurodegenerative diseases, given the importance of the “gut-brain” axis. There is a strong interplay between Adiponectin, gut microbiota, and brain-gut axis. For these reasons, a healthy diet composed of healthy nutrients such as probiotics, prebiotics, polyphenols, can prevent many metabolic and inflammatory diseases such as neurodegenerative diseases and obesity. The special Adiponectin role should be taken into account also, in order to be able to use this component as a therapeutic molecule.


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