280 poster Breast-conservation treatment intensified with anti-estrogen agent and CAF chemotherapy without axiliary dissection for 100 patients with T1, T2N0 breast cancer

2001 ◽  
Vol 58 ◽  
pp. S78
The Breast ◽  
2005 ◽  
Vol 14 ◽  
pp. S28-S29
Author(s):  
V. Parmar ◽  
R.A. Badwe ◽  
R. Sarin ◽  
R. Jalali ◽  
R. Chinoy ◽  
...  

2002 ◽  
Vol 57 (3) ◽  
pp. 159-160
Author(s):  
Fawzia Ashkanani ◽  
Tarun Sarkar ◽  
Gillian Needham ◽  
Adam Coldwells ◽  
Antoine K. Ah-See ◽  
...  

2006 ◽  
Vol 24 (25) ◽  
pp. 4100-4106 ◽  
Author(s):  
Eleanor E.R. Harris ◽  
Candace Correa ◽  
Wei-Ting Hwang ◽  
Jessica Liao ◽  
Harold I. Litt ◽  
...  

Purpose Several studies have reported increased cardiac mortality related to the use of left-sided breast or chest-wall irradiation. This study was undertaken as a comprehensive examination of the long-term cardiac mortality and morbidity after breast irradiation using contemporary irradiation techniques. Methods The medical records of 961 consecutive patients presenting between 1977 and 1994 with stage I or II breast cancer treated with breast conservation treatment were reviewed. Data was recorded on baseline pretreatment patient, tumor and treatment characteristics and on subsequent cancer or cardiac related events. The median follow-up time was 12 years. Results There was no difference in overall mortality from any cardiac cause (P = .25). Death from any cardiac cause occurred in 2% of right-sided patients and 3.5% of left-sided patients. However, in the second decade after treatment, there was a higher rate of cardiac deaths in left-sided patients, with a cumulative risk of 6.4% (95% CI, 3.5% to 11.5%) for left-sided compared with 3.6% (95% CI, 1.8% to 7.2%) for right-sided patients at 20 years. There were statistically higher rates of chest pain, coronary artery disease, and myocardial infarction diagnosed in left-sided patients (all P ≤ .002). The presence of hypertension was associated with a higher risk of coronary artery disease in left-sided patients. Conclusion Irradiation to the left breast is not associated with a higher risk of cardiac death up to 20 years after treatment, but is associated with an increased rate of diagnoses of coronary artery disease and myocardial infarction compared with right breast treatment.


2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10527-10527
Author(s):  
V. Bar Ad ◽  
A. Cheville ◽  
N. Amin ◽  
J. Booty ◽  
L. J. Solin ◽  
...  

10527 Background: Arm lymphedema (ALE) is a serious consequence of the treatment for breast carcinoma. The objective of the current retrospective study was to analyze the time-course of minimal ALE after breast conservation treatment for early stage breast cancer. Methods: The study cohort was drawn from consecutive stage I or II patients who underwent breast conservation therapy including axillary staging followed by radiation. During follow up assessments after treatment, measurements of arm circumference were frequently performed at regular intervals, for clinically evident swelling of the arm or for complaints of swelling of the arm. ALE was documented in 274 of 1861 (15%) patients. 109 patients, 6% of overall group, and 40% of the patients with lymphedema, presented with minimal ALE, defined as a difference of 2 cm or less between the affected and unaffected arms. Results: The median age of patients was 54 years. The median interval to develop ALE was 1 year. The median follow up was 11 years. Among all 109 patients with minimal grade ALE at the time of ALE diagnosis, 21%, 13% and 14% of the patients progressed to more severe grades of lymphedema after 1,3 and 5 years of follow-up, respectively (See table). 40% of the patients with minimal grade ALE received therapy for lymphedema. Despite treatment for minimal grade ALE, 37% of treated patients progressed to more severe grades of lymphedema at 1 year follow up, and 24% progressed at 3 and 5 years follow up. Conclusions: Minimal ALE after breast conservation therapy, including axillary staging, developed in 6% of stage I or II breast cancer patients. Minimal ALE has the potential to progress to more severe grade of ALE. Despite treatment for lymphedema for minimal grade ALE, some patients still progressed to more severe grades of lymphedema. [Table: see text] No significant financial relationships to disclose.


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