L-proline and glycine transport system from brain to blood across the blood-brain barrier

2000 ◽  
Vol 38 ◽  
pp. S62
Author(s):  
N Tokuda
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Brain Barrier ◽  
Blood Brain ◽  
Glycine Transport

Transport of alpha-keto analogues of amino acids across blood-brain barrier in rats

1982 ◽  
Vol 243 (4) ◽  
pp. E272-E277
Author(s):  
A. R. Conn ◽  
R. D. Steele
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Ketone Bodies ◽  
Brain Barrier ◽  
Sodium Pentobarbital ◽  
Keto Acid ◽  
Dual Isotope ◽  
Common System ◽  
Blood Brain ◽  
Keto Acids

The transport of 14C-labeled alpha-keto acids across the blood-brain barrier (BBB) was studied in rats anesthetized with sodium pentobarbital using a modification of a single-injection dual-isotope technique. alpha-Keto acids were found to cross the BBB via a saturable carrier-mediated transport system that may be specific based on lack of inhibition by glucose, isoleucine, and ketone bodies on the uptake of tracer levels of 14C-labeled alpha-keto acids. alpha-Ketobutyrate and alpha-keto-gamma-methiolbutyrate, both straight chain keto acids, and alpha-ketoisocaproate, a branched-chain keto acid, appeared to cross the barrier by a common carrier based on cross-inhibition studies. Aromatic keto acids had no effect on the uptake of tracer levels of these 14C-keto acids. The Km of transport of alpha-ketobutyrate, alpha-ketoisocaproate, and alpha-keto-gamma-methiolbutyrate, was 0.11, 0.60, and 0.33 mM, respectively. The corresponding Vmax was 15.7, 73.3, and 30.2 nmol . g-1 . min-1. Phenylpyruvate was found not to cross the BBB. Inhibition of brain uptake of alpha-keto acids by propionate and pyruvate, and not by DL-beta-hydroxybutyrate suggests that alpha-keto acids and monocarboxylic acids are transported either via a common system independent of ketone bodies or share an affinity with a monocarboxylic acid and an alpha-keto acid transport system.

Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier 1

Life Sciences ◽  
2000 ◽  
Vol 66 (7) ◽  
pp. 649-662 ◽  
Author(s):  
Yoshiharu Deguchi ◽  
Yoshinari Yokoyama ◽  
Tatsuichiro Sakamoto ◽  
Hideki Hayashi ◽  
Takafumi Naito ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Brain Barrier ◽  
Brain Distribution ◽  
Efflux Transport ◽  
Blood Brain

Stereospecific transport of Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1

1990 ◽  
Vol 25 (4) ◽  
pp. 589-592 ◽  
Author(s):  
William A. Banks ◽  
Abba J. Kastin ◽  
Edward A. Michals ◽  
Carlos M. Barrera
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Blood Brain ◽  
System 1

Interleukin-2 does not cross the blood-brain barrier by a saturable transport system

1994 ◽  
Vol 34 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Paul J. Waguespack ◽  
William A. Banks ◽  
Abba J. Kastin
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Interleukin 2 ◽  
Brain Barrier ◽  
Blood Brain

A non-invasive transport system for GDNF across the blood–brain barrier

Neuroreport ◽  
1997 ◽  
Vol 8 (9) ◽  
pp. 2293-2298 ◽  
Author(s):  
David S. Albeck ◽  
Barry J. Hoffer ◽  
David Quissell ◽  
Linda A. Sanders ◽  
Gary Zerbe ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Brain Barrier ◽  
Non Invasive ◽  
Blood Brain
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