The effects of microglial activation factors on the survival and neurite outgrowth of cultured purified retinal ganglion cells

2000 ◽  
Vol 38 ◽  
pp. S142
Author(s):  
K Morigiwa
Keyword(s):  
Neurite Outgrowth ◽  
Retinal Ganglion Cells ◽  
Microglial Activation ◽  
Ganglion Cells ◽  
Retinal Ganglion

Effect of Lens Lesion on Neurite Outgrowth of Retinal Ganglion Cells

2002 ◽  
Vol 21 (2) ◽  
pp. 301-311 ◽  
Author(s):  
B LORBER ◽  
M BERRY ◽  
A LOGAN ◽  
D TONGE
Keyword(s):  
Neurite Outgrowth ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

The Peptides ADNF-9 and NAP Increase Survival and Neurite Outgrowth of Rat Retinal Ganglion Cells In Vitro

2005 ◽  
Vol 46 (3) ◽  
pp. 933 ◽  
Author(s):  
Wolf A. Lagre`ze ◽  
Amelie Pielen ◽  
Ruth Steingart ◽  
Gu¨nther Schlunck ◽  
Hans-Dieter Hofmann ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

scholarly journals A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 252 ◽  
Author(s):  
Hong-Jia-Qi Sun ◽  
Dong-Dong Xue ◽  
Bing-Zheng Lu ◽  
Yuan Li ◽  
Long-Xiang Sheng ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Calcium Binding ◽  
Microglial Activation ◽  
Nuclear Translocation ◽  
Ganglion Cells ◽  
Ischemia Reperfusion ◽  
Potential Candidate ◽  
Retinal Ganglion ◽  
Raw264.7 Macrophages ◽  
Acute Glaucoma

Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of acute glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents in the clinical treatment of acute glaucoma. Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), a novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated the loss of retinal ganglion cells (RGCs) caused by acute intraocular hypertension (AIH). The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in BV2 microglia and RAW264.7 macrophages. Moreover, immunofluorescence and western blotting analysis revealed that sterone markedly abrogated the nuclear translocation and phosphorylation of nuclear factor-κB (NF-κB) p65 subunit. Furthermore, sterone significantly suppressed the inflammatory microglial activation and RGCs’ reduction caused by retinal ischemia/reperfusion (I/R) injury in a rat AIH model. These results suggest sterone may be a potential candidate in the treatment of acute glaucoma caused by microglial activation-mediated neuroinflammatory injury.

Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells

2018 ◽  
Vol 170 ◽  
pp. 160-168 ◽  
Author(s):  
Kei-Ichi Nakashima ◽  
Keiichiro Iwao ◽  
Toshihiro Inoue ◽  
Akira Haga ◽  
Takayuki Tsutsumi ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Adenosine A3 Receptor ◽  
Promote Neurite Outgrowth ◽  
A2 Receptors ◽  
Stimulation Of

scholarly journals Neurite Outgrowth of Mature Retinal Ganglion Cells and PC12 Cells Requires Activity of CK1δ and CK1ε

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20857 ◽  
Author(s):  
Joachim Bischof ◽  
Adrienne Müller ◽  
Miriam Fänder ◽  
Uwe Knippschild ◽  
Dietmar Fischer
Keyword(s):  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion
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