a2 receptors
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2021 ◽  
Vol 232 ◽  
pp. 102784
Author(s):  
Alec L.E. Butenas ◽  
Korynne S. Rollins ◽  
Auni C. Williams ◽  
Shannon K. Parr ◽  
Stephen T. Hammond ◽  
...  

2020 ◽  
Vol 21 (22) ◽  
pp. 8781
Author(s):  
Ivana Novak ◽  
Haoran Yu ◽  
Lara Magni ◽  
Ganga Deshar

The purinergic signaling has an important role in regulating pancreatic exocrine secretion. The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic ductal adenocarcinoma (PDAC). Here, we explore how the network of purinergic and adenosine receptors, as well as ecto-nucleotidases regulate normal pancreatic cells and various cells within the pancreatic tumor microenvironment. In particular, we focus on the P2X7 receptor, P2Y2 and P2Y12 receptors, as well as A2 receptors and ecto-nucleotidases CD39 and CD73. Recent studies indicate that targeting one or more of these candidates could present new therapeutic approaches to treat pancreatic cancer. In pancreatic cancer, as much as possible of normal pancreatic function should be preserved, and therefore physiology of purinergic signaling in pancreas needs to be considered.


2020 ◽  
Vol 319 (2) ◽  
pp. H320-H330
Author(s):  
Korynne S. Rollins ◽  
Alec L. E. Butenas ◽  
Kennedy P. Felice ◽  
Jacob E. Matney ◽  
Auni C. Williams ◽  
...  

We demonstrate that thromboxane A2 receptors, but not endoperoxide 4 receptors, on the sensory endings of thin fiber muscle afferents contribute to the chronic sensitization of the muscle mechanoreflex in rats with a ligated femoral artery (a model of simulated peripheral artery disease). The data may have important implications for our understanding of blood pressure control during exercise in patients with peripheral artery disease.


2018 ◽  
Vol 170 ◽  
pp. 160-168 ◽  
Author(s):  
Kei-Ichi Nakashima ◽  
Keiichiro Iwao ◽  
Toshihiro Inoue ◽  
Akira Haga ◽  
Takayuki Tsutsumi ◽  
...  

2017 ◽  
Vol 39 (4) ◽  
pp. 312-318 ◽  
Author(s):  
Xiaona Xie ◽  
Wanchun Sun ◽  
Jun Wang ◽  
Xiaoou Li ◽  
Xiaofeng Liu ◽  
...  

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii159-iii160
Author(s):  
Kentaro Fujii ◽  
Kazutoshi Miyashita ◽  
Akiko Kubo ◽  
Masaaki Sato ◽  
Aika Hagiwara ◽  
...  

2015 ◽  
Vol 93 (8) ◽  
pp. 667-675 ◽  
Author(s):  
Yves Jammes ◽  
Fabrice Joulia ◽  
Jean Guillaume Steinberg ◽  
Sylvie Ravailhe ◽  
Stéphane Delpierre ◽  
...  

Intravenous (i.v.) injections of adenosine exert marked effects on heart rate (HR) and arterial blood pressure (BP), but the role of an endogenous adenosine release by vagal stimulation has not been evaluated. In anaesthetized rats, we examined HR and BP changes induced by 1 min electrical vagal stimulation in the control condition, and then after i.v. injections of (i) atropine, (ii) propranolol, (iii) caffeine, (iv) 8 cyclopentyl-1,3-dipropylxanthine (DPCPX), or (v) dipyridamole to increase the plasma concentration of adenosine (APC). APC was measured by chromatography in the arterial blood before and at the end of vagal stimulation. The decrease in HR in the controls during vagal stimulation was markedly attenuated, but persisted after i.v. injections of atropine and propranolol. When first administered, DPCPX modestly but significantly reduced the HR response to vagal stimulation, but this disappeared after i.v. caffeine administration. Both the HR and BP responses were significantly accentuated after i.v. injection of dipyridamole. Vagal stimulation induced a significant increase in APC, proportional to the magnitude of HR decrease. Our data suggest that the inhibitory effects of electrical vagal stimulations on HR and BP were partly mediated through the activation of A1 and A2 receptors by an endogenous adenosine release. Our experimental data could help to understand the effects of ischemic preconditioning, which are partially mediated by adenosine.


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