Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer

2002 ◽  
Vol 81 (3) ◽  
pp. 251-261 ◽  
Author(s):  
Tommy Tarvainen ◽  
Teija Karjalainen ◽  
Minna Malin ◽  
Satu Pohjolainen ◽  
Jukka Tuominen ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Poly Lactic Acid

scholarly journals Drug Release from Electrospun Poly(Lactic Acid) Membranes and Their Cell Viability in Vitro Test

2012 ◽  
Vol 44 ◽  
pp. 866-868 ◽  
Author(s):  
A.P.S. Immich ◽  
M. Lis ◽  
L.H. Catalani ◽  
R.L. Boemo ◽  
J.A. Tornero
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Cell Viability ◽  
Poly Lactic Acid ◽  
In Vitro Test ◽  
Vitro Test

Synthesis and Kinetic Studies on Controlled Release of 6-Thioguanine Entrapped Polyethylene Glycol-Co-Polylactic Acid Polymer Nanoparticles

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Sathishkumar Kannaiyan ◽  
T.G.Ashwin Narayanan ◽  
P.Karthick Sarathy ◽  
Nagarjun Sudhakar ◽  
Rama Krishnan
Keyword(s):  
Gold Nanoparticles ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Controlled Release ◽  
Drug Release ◽  
Kinetic Equations ◽  
Kinetic Studies ◽  
Poly Lactic Acid ◽  
Average Size

Poly lactic acid-polyethylene glycol (PLA-co-PEG) copolyester was synthesized from oligomer of L-lactic acid and poly ethylene glycol (PEG) using stannous octoate as catalyst. 6-Thioguanine containing Poly lactic acid-polyethylene glycol (PLA-co-PEG) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules changed substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm, respectively. In general the drug release was quicker in Phosphate buffer saline (pH 7.4) compared to 0.1M hydrochloric acid and this may be due to higher solubility, higher swelling and penetration properties of PLA-co-PEG in PBS compared to HCl. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency (75%) compared to that of polymer nanocapsules (45%) in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Application of in vitro drug release data to various kinetic equations indicated Higuchi model, indicating a uniform distribution of thioguanine in the nanocapsules.

Dextrin crosslinked with poly(lactic acid): A novel hydrogel for controlled drug release application

2013 ◽  
Vol 131 (7) ◽  
pp. n/a-n/a ◽  
Author(s):  
Dipankar Das ◽  
Raghunath Das ◽  
Jayanta Mandal ◽  
Animesh Ghosh ◽  
Sagar Pal
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Lactic Acid

Assessment of structural, biological and drug release properties of electro-sprayed poly lactic acid-dexamethasone coating for biomedical applications

2021 ◽  
Vol 11 (4) ◽  
pp. 393-406
Author(s):  
Mostafa Rahvar ◽  
Gholamreza Ahmadi Lakalayeh ◽  
Niloofar Nazeri ◽  
Bahereh T. Marouf ◽  
Mahdieh Shirzad ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Biomedical Applications ◽  
Poly Lactic Acid

Synthesis, drug release and targeting behaviors of Novel Folated Pluronic F87/poly(lactic acid) block copolymer

2015 ◽  
Vol 68 ◽  
pp. 233-242 ◽  
Author(s):  
Xiang Yuan Xiong ◽  
Xiang Qin ◽  
Zi Ling Li ◽  
Yan Chun Gong ◽  
Yu Ping Li
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Drug Release ◽  
Poly Lactic Acid
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