Preparation of phylloquinone-loaded poly(lactic acid)/hydroxyapatite core–shell particles and their drug release behavior

2016 ◽  
Vol 27 (3) ◽  
pp. 903-907 ◽  
Author(s):  
Fukue Nagata ◽  
Tatsuya Miyajima ◽  
Katsuya Kato
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Shell Particles

Preparation and Drug Release Behavior of Nifedipine-Loaded Poly(lactic acid)/Polyethylene Glycol Microcapsules

2021 ◽  
Vol 21 (7) ◽  
pp. 3735-3741
Author(s):  
Heeseok Jeong ◽  
Hyunju Lim ◽  
Deuk Yong Lee ◽  
Yo-Seung Song ◽  
Bae-Yeon Kim
Keyword(s):  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Drug Release ◽  
Release Rate ◽  
Drug Carriers ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Release Rate ◽  
Water Emulsion ◽  
Drug Release Behavior

Nifedipine (NF)-loaded poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) microcapsules are synthesized using a high-speed agitator and a syringe pump with an oil-in-water emulsion-solvent evaporation technique to evaluate the effect of PLA/PEG ratio on morphology and drug release behavior of the capsules. Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimeter (DSC), and X-ray diffraction (XRD) results indicate that PEG reacts successfully with PLA due to the ether bond between PEG and PLA. The drug release rate of PLA and PLA/PEG capsules increases dramatically from 0 to 5 min and then reaches a plateau within 15 to 20 min. Due to the high specific surface area, the amount of NF released is raised by reducing the PLA concentration from 5 wt% to 2 wt%. Unlike PLA capsules, the drug release rate of PLA/PEG capsules increases due to the size effect by varying the PLA/PEG ratio from 10/0 to 6/4. Larger PLA/PEG capsules are attributed to higher amounts of encapsulated NF. The capsules show no evidence of cytotoxicity, suggesting that the PLA and PLA/PEG drug carriers are clinically safe.

scholarly journals Ionic Diffusion and Drug Release Behavior of Core–Shell-Functionalized Alginate–Chitosan-Based Hydrogel

ACS Omega ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 758-765 ◽  
Author(s):  
Deepak Kumar Khajuria ◽  
Ramakrishna Vasireddi ◽  
Manish Kumar Priydarshi ◽  
Debiprosad Roy Mahapatra
Keyword(s):  
Drug Release ◽  
Ionic Diffusion ◽  
Core Shell ◽  
Release Behavior ◽  
Drug Release Behavior

scholarly journals Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1959
Author(s):  
Seiya Suzuki ◽  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Katsuya Kato ◽  
Ayae Sugawara-Narutaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Loading ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Vitamin K1 ◽  
Acidic Conditions ◽  
Living Organisms ◽  
Shell Particles ◽  
Hydrophobic Substance

Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The particles were 40–80 nm in diameter with a PLA core and a HAp shell. The particle size increased with an increase in the vitamin K1 loading. The drug-loading capacity (LC) value of the particles, an indicator of their drug-loading ability, was approximately 250%, which is higher than the previously reported values. The amount of vitamin K1 released from the particles increased as the pH of the soaking solution decreased because the HAp shell easily dissolved under the acidic conditions. The PLA/HAp particles prepared in this work were found to be promising candidates for drug delivery carriers because of their excellent drug-loading ability and pH sensitivity.

A New Approach for Polymer-Free Coating with Paclitaxel Microparticles on Fully-Bioabsorbable Poly(l-Lactic Acid) Stent and Studies of Drug Release Behavior

2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Hirokazu Yamada ◽  
Mitsuhiko Kinoshita ◽  
Shinichi Yagi ◽  
Chisa Matsubara ◽  
Keiji Igaki ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Crystal Growth ◽  
Drug Release ◽  
Aqueous Solubility ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Initial Release ◽  
Antiproliferative Agent ◽  
Plla Stent ◽  
Growth Formation

A first clinically-used, fully-bioabsorbable poly(L-lactic acid) (PLLA) stent was coated with microcrystals of paclitaxel (PTX), antiproliferative agent through seeding and/or crystal growing technique to investigate the drug properties on the stent surface and drug release behavior from the stent. PTX particles subject to only seeding process was peeled off after stent compression, while less PTX was coated on the stent subject to only crystal growth without seeding. PLLA stent with both processes could stably maintain an increased amount of PTX on its surface. The maximum amount of initial release (10 μg/cm2) was found in the sample only with seeding, which decreased to 3 μg/cm2 or below after one week. Also in the PLLA stent only with crystal growth, release amount decreased after one week. In the PLLA stent with seeding and crystal growth, formation of needle-like PTX crystals on the surface resulted in decreased initial release and lower solubility after hydration in phosphate buffered solution compared to other types of stent with different procedures. It is suggested that both seeding and crystal growth are required for stable application of PTX on fully-bioabsorbable PLLA stent and needle-like crystals containing water have lower aqueous solubility resulting in decreased PTX release.

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