[255] RELATION BETWEEN T29C SINGLE NUCLEOTIDE POLYMORPHISM OF ESTROGEN RECEPTOR ALPHA (ESR1) AND HBV-RELATED HEPATOCELLULAR CARCINOMA IN A CHINESE POPULATION

2007 ◽  
Vol 46 ◽  
pp. S103
Author(s):  
G.H. Deng ◽  
R. Zhang ◽  
G.Q. Zhou ◽  
L. Chen ◽  
F.C. He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphism ◽  
Estrogen Receptor ◽  
Chinese Population ◽  
Estrogen Receptor Alpha ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Receptor Alpha

scholarly journals Association between Single-Nucleotide Polymorphism in MicroRNA Target Site of DDB2 and Risk of Hepatocellular Carcinoma in a Southern Chinese Population

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Moqin Qiu ◽  
Yingchun Liu ◽  
Zihan Zhou ◽  
Yanji Jiang ◽  
Qiuling Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphism ◽  
Chinese Population ◽  
Excision Repair ◽  
Target Site ◽  
Hbv Infection ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Infected Population ◽  
Southern Chinese

Damage-specific DNA-binding protein 2 (DDB2) is a DNA repair protein mainly involved in nucleotide excision repair, which plays a pivotal role in maintaining genomic stability. In this study, we evaluated the association of single-nucleotide polymorphism (SNP) rs1050244 in miRNA target site of DDB2 gene with risk of hepatocellular carcinoma (HCC) among 1073 HCC patients and 1119 cancer-free controls in a southern Chinese population. Our results showed that no statistically significant association was found between DDB2 rs1050244 and HCC risk. In further analysis stratified by age, sex, smoking, alcohol drinking, and HBV infection status, we found that individuals carrying the CT/TT genotypes of SNP rs1050244 had a significantly decreased risk of HCC compared with those with the CC genotype among non-HBV infected population (adjusted OR = 0.31, 95% CI = 0.13–0.72), and a significant interaction was found between this SNP and HBV infection (Pinteraction=0.002). Our results suggested that the DDB2 rs1050244 C>T polymorphism was associated with the decreased risk of HCC among non-HBV infected population. Further studies with larger sample sizes are needed to validate our findings.

scholarly journals YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior

2021 ◽  
Author(s):  
Youngsic Jeon ◽  
Jeong Eun Yoo ◽  
Hyungjin Rhee ◽  
Young-Joo Kim ◽  
Gwang Il Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Nuclear Translocation ◽  
Disease Free Survival ◽  
Cancer Cell Growth ◽  
Receptor Alpha ◽  
Downstream Signaling ◽  
Favorable Prognosis ◽  
Serum Alpha Fetoprotein

AbstractThe expression of estrogen receptor alpha (ERα, encoded by ESR1) has been shown to be associated with the prognostic outcomes of patients in various cancers; however, its prognostic and mechanistic significance in hepatocellular carcinoma (HCC) remain unclear. Here, we evaluated the expression of ERα and its association with clinicopathological features in 339 HCC patients. ERα was expressed in 9.4% (32/339) of HCCs and was related to better overall survival (OS; hazard ratio [HR] = 0.11, p = 0.009, 95% C.I. = 0.016–0.82) and disease-free survival (DFS, HR = 0.4, p = 0.013, 95% C.I. = 0.18–0.85). ERα expression was also associated with features related to more favorable prognosis, such as older age, lower serum alpha-fetoprotein level, and less microvascular invasion (p < 0.05). In addition, to obtain mechanistic insights into the role of ERα in HCC progression, we performed integrative transcriptome data analyses, which revealed that yes-associated protein (YAP) pathway was significantly suppressed in ESR1-expressing HCCs. By performing cell culture experiments, we validated that ERα expression enhanced YAP phosphorylation, attenuating its nuclear translocation, which in turn suppressed the downstream signaling pathways and cancer cell growth. In conclusion, we suggest that ERα expression is an indicator of more favorable prognosis in HCC and that this effect is mediated by inactivation of YAP signaling. Our results provide new clinical and pathobiological insights into ERα and YAP signaling in HCC.

Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors

2011 ◽  
Vol 21 (5) ◽  
pp. 263-269 ◽  
Author(s):  
Patrik Romerius ◽  
Aleksander Giwercman ◽  
Christian Moëll ◽  
Thomas Relander ◽  
Eva Cavallin-Ståhl ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Estrogen Receptor ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Estrogen Receptor Α ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jian Zhang ◽  
Jianwei Ren ◽  
Jiamin Wei ◽  
Charing C. N. Chong ◽  
Dongjie Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Estrogen Receptor ◽  
Alternative Splicing ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

scholarly journals SNP rs2596542G>A in MICA is associated with risk of hepatocellular carcinoma: a meta-analysis

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Haichuan Wang ◽  
Hui Cao ◽  
Zhong Xu ◽  
Dong Wang ◽  
Yong Zeng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Single Nucleotide Polymorphism ◽  
Web Of Science ◽  
Meta Analysis ◽  
Genetic Models ◽  
Complex Class ◽  
Related Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Histocompatibility Complex

Abstract The association of major histocompatibility complex class I chain-related gene A (MICA) single nucleotide polymorphism (SNP) rs2596542G>A and hepatocellular carcinoma (HCC) has been broadly studied, with inconsistent results. Therefore, we conducted the current meta-analysis to better elucidate the roles of SNP rs2596542G>A in HCC. Eligible articles were searched in PubMed, CNKI, Wanfang, Embase, VIP, Web of Science, and CBM databases up to November 2018. Odds ratios (ORs) and 95% CIs were applied. A total of 11 articles, including 4528 HCC patients and 16,625 control subjects, were analyzed. Results revealed that rs2596542G>A was significantly associated with HCC in the heterozygote (G/A versus A/A, P=0.006, OR = 0.854; 95% CI: 0.763–0.956); and dominant (G/G + G/A versus A/A; P=0.021; OR = 0.796; 95% CI: 0.655–0.967) genetic models. Nevertheless, we also detected significant associations between rs2596542G>A and HCV-induced HCC. Additionally, according to our analyses, SNP rs2596542G>A was not correlated with HBV-induced HCC. In conclusion, our findings suggest that MICA SNP rs2596542G>A is associated with HCC susceptibility amongst the Asian, Caucasian, and African ethnicity in certain genetic models. Specifically, MICA SNP rs2396542G>A is associated with risk of HCV-induced HCC, not HBV-induced HCC.

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