P574 HIGH SENSITIVITY C-REACTIVE PROTEIN IS AN INDEPENDENT PREDICTOR FOR RECURRENCE AND SURVIVAL AFTER CURATIVE TREATMENT AMONG PATIENTS WITH HCV-RELATED HEPATOCELLULAR CARCINOMA IN EARLY STAGE

2014 ◽  
Vol 60 (1) ◽  
pp. S260-S261 ◽  
Author(s):  
N. Fujiwara ◽  
R. Tateishi ◽  
R. Nakagomi ◽  
M. Kondo ◽  
T. Minami ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Independent Predictor ◽  
Early Stage ◽  
High Sensitivity ◽  
Curative Treatment ◽  
C Reactive Protein ◽  
Reactive Protein

Slight elevation of high-sensitivity C-reactive protein to predict recurrence and survival in patients with early stage hepatitis C-related hepatocellular carcinoma

2014 ◽  
Vol 45 (6) ◽  
pp. 645-655 ◽  
Author(s):  
Naoto Fujiwara ◽  
Ryosuke Tateishi ◽  
Hayato Nakagawa ◽  
Ryo Nakagomi ◽  
Mayuko Kondo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
Early Stage ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Slight Elevation

Highly Sensitive and Fast Detection of C-Reactive Protein and Troponin Biomarkers Using Liquid-gated Single Silicon Nanowire Biosensors

MRS Advances ◽  
2020 ◽  
Vol 5 (16) ◽  
pp. 835-846 ◽  
Author(s):  
Yurii Kutovyi ◽  
Jie Li ◽  
Ihor Zadorozhnyi ◽  
Hanna Hlukhova ◽  
Nazarii Boichuk ◽  
...  
Keyword(s):  
Troponin I ◽  
Early Stage ◽  
Silicon Nanowire ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Label Free ◽  
C Reactive Protein ◽  
Force Microscopy ◽  
Reactive Protein ◽  
Detection Of Biomarkers

ABSTRACTC-reactive protein (CRP) and cardiac troponin I (cTnI) biomolecules represent the earliest enzymes that appear in the blood when a cardiac injury occurs. Real-time and selective detection of these biomarkers is essential for the prediction and detection of cardiovascular diseases at an early stage. Here we report on the label-free specific detection of both proteins at picomolar concentrations using fabricated nanowire-based biosensors. We demonstrate a novel functionalization technique based on the attachment of dibenzocyclooctyne (DBCO)-linked troponin-specific aptamers to azide-functionalized silicon (Si) nanowire (NW) surface. Due to the fast and reliable immobilization of cTnI-specific aptamers and CRP-specific antibodies on the Si NWs, the fabricated devices can rapidly detect target biomolecules demonstrating high sensitivity. We confirm the attachment of proteins to the surface of Si NWs by atomic force microscopy (AFM). Moreover, we demonstrate that nanowire structures of different sizes enable the detection of biomarkers in a wide concentration range (from 1 pg/ml to 1 µg/ml), corresponding to CRP and cTnI elevation levels during the early stage of disease formation.

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