Active Antiviral Treatment for Chronic Hepatitis C Virus Infection Needs to be Recommended for Decreasing Hepatitis C-Associated Hepatocellular Carcinoma Risk in the New Era of Highly Effective Oral Antiviral Drugs

2016 ◽  
Vol 64 (2) ◽  
pp. S830
Author(s):  
Y.-J. Jin ◽  
J.T. Hong ◽  
J.-W. Lee
2015 ◽  
Vol 156 (21) ◽  
pp. 855-861 ◽  
Author(s):  
Alajos Pár ◽  
Áron Vincze ◽  
Gabriella Pár

Chronic hepatitis C virus infection associated with necroinflammation predisposes to liver fibrosis and cirrhosis, which lead to severe end-stage complications. Staging of fibrosis is of basic importance for the indication of antiviral treatment, for monitoring the response and predicting the prognosis of patients with hepatitis C virus related liver disease. Since liver biopsy, the “gold standard” diagnosis of fibrosis is invasive and it has some other limitations, non-invasive methods have been developed and widely used in the clinical practice. Serum biomarkers and physical approaches measuring liver stiffness by elastography as well as combination algorithms have been gradually been integrated into guidelines resulting in a reduction of the need for liver biopsy. The authors review these non-invasive fibrosis markers and discuss their role in the indication of treatment, follow-up, and assessment of prognosis of patients with chronic hepatitis C virus infection. Orv. Hetil., 2015, 156(21), 855–861.


Hepatology ◽  
2010 ◽  
Vol 52 (2) ◽  
pp. 518-527 ◽  
Author(s):  
Yasuhiro Asahina ◽  
Kaoru Tsuchiya ◽  
Nobuharu Tamaki ◽  
Itsuko Hirayama ◽  
Tomohiro Tanaka ◽  
...  

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