448 Age-related amyloid β protein accumulation induces cellular death and macrophage activation

1996 ◽  
Vol 17 (4) ◽  
pp. S111-S112
Author(s):  
M. Shoji ◽  
T. Kawarabayashi ◽  
Y. Igeta ◽  
Y. Tomidokoro ◽  
K. Ishiguro ◽  
...  
Keyword(s):  
Macrophage Activation ◽  
Amyloid Β ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Cellular Death ◽  
Age Related ◽  
Β Protein

Neuronal apoptosis is accompanied by amyloid β-protein accumulation in the endoplasmic reticulum

2002 ◽  
Vol 4 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Roberta Borghi ◽  
Luca Pellegrini ◽  
Emanuela Lacaná ◽  
Alberto Diaspro ◽  
Maria Adelaide Pronzato ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Neuronal Apoptosis ◽  
Amyloid Β ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain

2000 ◽  
Vol 157 (6) ◽  
pp. 2093-2099 ◽  
Author(s):  
Maho Morishima-Kawashima ◽  
Noriko Oshima ◽  
Hiromitsu Ogata ◽  
Haruyasu Yamaguchi ◽  
Masahiro Yoshimura ◽  
...  
Keyword(s):  
Human Brain ◽  
Apolipoprotein E ◽  
Initial Phase ◽  
Amyloid Β ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Β Protein

Fucosyl-GM1 expression and amyloid-β protein accumulation in PC12 cells

2006 ◽  
Vol 84 (6) ◽  
pp. 1343-1349 ◽  
Author(s):  
Makoto Yanagisawa ◽  
Toshio Ariga ◽  
Robert K. Yu
Keyword(s):  
Pc12 Cells ◽  
Amyloid Β ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Β Protein

Herpes Simplex Virus Type-1 Infection Impairs Adult Hippocampal Neurogenesis via Amyloid-β Protein Accumulation

Stem Cells ◽  
2019 ◽  
Vol 37 (11) ◽  
pp. 1467-1480 ◽  
Author(s):  
Domenica Donatella Li Puma ◽  
Roberto Piacentini ◽  
Lucia Leone ◽  
Katia Gironi ◽  
Maria Elena Marcocci ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Amyloid Β ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Simplex Virus

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex

2016 ◽  
Vol 52 (4) ◽  
pp. 1209-1214 ◽  
Author(s):  
Anna Pliássova ◽  
Paula M. Canas ◽  
Ana Carolina Xavier ◽  
Beatriz S. da Silva ◽  
Rodrigo A. Cunha ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Human Cerebral Cortex ◽  
Synaptic Density ◽  
Protein Precursor ◽  
Age Related ◽  
Β Protein ◽  
Age Related Changes

scholarly journals Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

2021 ◽  
Vol 15 ◽  
Author(s):  
Zenghui Wei ◽  
Jagadish Koya ◽  
Sandra E. Reznik
Keyword(s):  
Insulin Resistance ◽  
Alzheimer Disease ◽  
Amyloid Β ◽  
The United States ◽  
Tau Phosphorylation ◽  
Protein Accumulation ◽  
Amyloid Β Protein ◽  
Insulin Degrading Enzyme ◽  
Pathogenic Mechanisms ◽  
Β Protein

Alzheimer disease (AD) is a chronic neurodegenerative disease that accounts for 60–70% of dementia and is the sixth leading cause of death in the United States. The pathogenesis of this debilitating disorder is still not completely understood. New insights into the pathogenesis of AD are needed in order to develop novel pharmacologic approaches. In recent years, numerous studies have shown that insulin resistance plays a significant role in the development of AD. Over 80% of patients with AD have type II diabetes (T2DM) or abnormal serum glucose, suggesting that the pathogenic mechanisms of insulin resistance and AD likely overlap. Insulin resistance increases neuroinflammation, which promotes both amyloid β-protein deposition and aberrant tau phosphorylation. By increasing production of reactive oxygen species, insulin resistance triggers amyloid β-protein accumulation. Oxidative stress associated with insulin resistance also dysregulates glycogen synthase kinase 3-β (GSK-3β), which leads to increased tau phosphorylation. Both insulin and amyloid β-protein are metabolized by insulin degrading enzyme (IDE). Defects in this enzyme are the basis for a strong association between T2DM and AD. This review highlights multiple pathogenic mechanisms induced by insulin resistance that are implicated in AD. Several pharmacologic approaches to AD associated with insulin resistance are presented.

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