P.67 Improvement of gut blood flow by enteral nutritionsupplemented with glutamine, omega-3 fatty acids and antioxidants in an endotoxin rat model

1997 ◽  
Vol 16 ◽  
pp. 40-41
Author(s):  
E. Pscheidl ◽  
Th. Bö-Prö
Keyword(s):  
Fatty Acids ◽  
Blood Flow ◽  
Rat Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 100 ◽  
Author(s):  
Laiali Alquraan ◽  
Karem H. Alzoubi ◽  
Hana Hammad ◽  
Suzie Y. Rababa’h ◽  
Fadia Mayyas
Keyword(s):  
Fatty Acids ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Impairment ◽  
Stress Disorder ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Post Traumatic Stress ◽  
Post Traumatic

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can happen after exposure to a traumatic event. Post-traumatic stress disorder is common among mental health disorders that include mood and anxiety disorders. Omega-3 fatty acids (OMGs) are essential for the maintenance of brain function and prevention of cognition dysfunctions. However, the possible effect of OMG on memory impairment induced by PTSD has not been studied. In here, such an effect was explored using a rat model of PTSD. The PTSD-like behavior was induced in animals using a single-prolonged stress (SPS) rat model of PTSD (2 h restraint, 20 min forced swimming, 15 min rest, 1–2 min diethyl ether exposure). The OMG was administered orally at a dose of 100 mg omega-3 polyunsaturated fatty acid (PUFA)/100 g body weight/day. Spatial learning and memory were assessed using the radial arm water maze (RAWM) method. Changes in oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS), and brain derived neuroptrophic factor (BDNF) in the hippocampus following treatments were measured. The results revealed that SPS impaired both short- and long-term memory (p < 0.05). Use of OMG prevented memory impairment induced by SPS. Furthermore, OMG normalized SPS induced changes in the hippocampus that reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratios, the activity of catalase, glutathione peroxidase (GPx), and TBARSs levels. In conclusion, the SPS model of PTSD-like behavior generated memory impairment, whereas OMG prevented this impairment, possibly through normalizing antioxidant mechanisms in the hippocampus.

P117 OMEGA-3 FATTY ACIDS INHIBIT OXIDATIVE STRES IN A RAT MODEL OF LIVER REGENERATION

2008 ◽  
Vol 3 ◽  
pp. 78
Author(s):  
O. Makay ◽  
O. Firat ◽  
G. Gokce ◽  
N. Sapaz ◽  
C. Yenisey ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Regeneration ◽  
Rat Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Belmiro Parada ◽  
Flávio Reis ◽  
Raquel Cerejo ◽  
Patrícia Garrido ◽  
José Sereno ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Rat Model ◽  
Redox Status ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Markers Of Inflammation ◽  
Male Wistar Rats ◽  
Serum Crp

Omega-3 (ω-3) fatty acids have been tested on prevention and treatment of several cancer types, but the efficacy on “in vivo” bladder cancer has not been analyzed yet. This study aimed at evaluating the chemopreventive efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mixture in an animal model of bladder cancer. Forty-four male Wistar rats were divided into 4 groups during a 20-week protocol: control; carcinogen—N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN);ω-3 (DHA + EPA); andω-3 + BBN. BBN andω-3 were given during the initial 8 weeks. At week 20 blood and bladder were collected and checked for the presence of urothelium lesions and tumors, markers of inflammation, proliferation, and redox status. Incidence of bladder carcinoma was, control (0%),ω-3 (0%), BBN (65%), andω-3 + BBN (62.5%). Theω-3 + BBN group had no infiltrative tumors or carcinomain situ, and tumor volume was significantly reduced compared to the BBN (0.9 ± 0.1 mm3versus 112.5 ± 6.4 mm3). Also, it showed a reduced MDA/TAS ratio and BBN-induced serum CRP, TGF-β1, and CD31 were prevented. In conclusion, omega-3 fatty acids inhibit the development of premalignant and malignant lesions in a rat model of bladder cancer, which might be due to anti-inflammatory, antioxidant, anti-proliferative, and anti-angiogenic properties.

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