A dengue virus serotype-1 DNA vaccine induces virus neutralizing antibodies and provides protection from viral challenge in Aotus monkeys

Vaccine ◽  
2000 ◽  
Vol 18 (27) ◽  
pp. 3166-3173 ◽  
Author(s):  
T.J Kochel ◽  
K Raviprakash ◽  
C.G Hayes ◽  
D.M Watts ◽  
K.L Russell ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
Neutralizing Antibodies ◽  
Viral Challenge ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotype 1

Induction of multiple cytotoxic T lymphocyte responses in mice by a multiepitope DNA vaccine against dengue virus serotype 1

2016 ◽  
Vol 60 (12) ◽  
pp. 835-845 ◽  
Author(s):  
Xin Yu Chen ◽  
De Zhou Li ◽  
Xiao Zhi Zhong ◽  
Bokun Chen ◽  
Zhi Liang Duan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dna Vaccine ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Lymphocyte Responses ◽  
Dengue Virus Serotype 1

scholarly journals Tracking the polyclonal neutralizing antibody response to a dengue virus serotype 1 type-specific epitope across two populations in Asia and the Americas

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Daniela V. Andrade ◽  
Colin Warnes ◽  
Ellen Young ◽  
Leah C. Katzelnick ◽  
Angel Balmaseda ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Sri Lankan ◽  
Human Monoclonal Antibodies ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotypes ◽  
Kinetics Of ◽  
Two Populations

Abstract The four dengue virus serotypes (DENV1-4) cause major public health problems worldwide. Highly neutralizing type-specific human monoclonal antibodies (hmAbs) target conformation-dependent epitopes on the DENV envelope protein, including 1F4, a DENV1 type-specific hmAb. Using a recombinant DENV2 virus displaying the DENV1 1F4 epitope (rDENV2/1), we measured the proportion and kinetics of DENV1 neutralizing antibodies targeting the 1F4 epitope in individuals living in Asia and the Americas where different DENV1 genotypes were circulating. Samples from 20 individuals were analyzed 3 and 18 months post-primary DENV1 infection, alongside samples from 4 individuals collected annually for four years post-primary DENV1 infection, from two studies in Nicaragua. We also analyzed convalescent post-primary DENV1 plasma samples from Sri Lankan individuals. We found that neutralizing antibodies recognizing the 1F4 epitope vary in prevalence across both populations and were detected from 20 days to four years post-infection. Additionally, both populations displayed substantial variability, with a range of high to low proportions of DENV1 type-specific neutralizing antibodies recognizing the 1F4 epitope seen across individuals. Thus, the 1F4 epitope is a major but not exclusive target of type-specific neutralizing antibodies post-primary infection with different DENV1 genotypes in Asia and Latin America, and additional epitopes likely contribute to type-specific neutralization of DENV1.

Force of infection of dengue serotypes in a population-based study in the northeast of Brazil

2012 ◽  
Vol 141 (5) ◽  
pp. 1080-1088 ◽  
Author(s):  
P. M. S. CASTANHA ◽  
M. T. CORDEIRO ◽  
C. M. T. MARTELLI ◽  
W. V. SOUZA ◽  
E. T. A. MARQUES ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Dengue Infection ◽  
Population Based ◽  
Northeastern Brazil ◽  
Population Based Study ◽  
Force Of Infection ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Frequent Infection ◽  
Dengue Virus Serotype 1

SUMMARYThis study investigated anti-dengue serotype-specific neutralizing antibodies in a random sample of dengue IgG-positive individuals identified in a survey performed in a hyperendemic setting in northeastern Brazil in 2005. Of 323 individuals, 174 (53·8%) had antibodies to dengue virus serotype 1 (DENV-1), 104 (32·2%) to DENV-2 and 301 (93·2%) to DENV-3. Monotypic infections by DENV-3 were the most frequent infection (35·6%). Of 109 individuals aged <15 years, 61·5% presented multitypic infections. The force of infection estimated by a catalytic model was 0·9%, 0·4% and 2·5% person-years for DENV-1, DENV-2 and DENV-3, respectively. By the age of 5 years, about 70%, 30% and 40% of participants were immune to DENV-3, DENV-2 and DENV-1, respectively. The data suggest that infection with DENV-1, -2 and -3 is intense at early ages, demonstrating the need for research efforts to investigate dengue infection in representative population samples of Brazilian children during early infancy.

scholarly journals Safety and Immunogenicity of a Dengue Virus Serotype-1 Purified-Inactivated Vaccine: Results of a Phase 1 Clinical Trial

2015 ◽  
Vol 93 (3) ◽  
pp. 454-460 ◽  
Author(s):  
Luis Javier Martinez ◽  
Leyi Lin ◽  
Jason M. Blaylock ◽  
Arthur G. Lyons ◽  
Kristen M. Bauer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dengue Virus ◽  
Phase 1 ◽  
Inactivated Vaccine ◽  
Phase 1 Clinical Trial ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotype 1

scholarly journals Rapid Subtyping of Dengue Virus Serotypes 1 and 4 by Restriction Site-Specific PCR

2000 ◽  
Vol 38 (3) ◽  
pp. 1286-1289 ◽  
Author(s):  
Marize P. Miagostovich ◽  
Flavia B. dos Santos ◽  
C. Milena Gutiérrez ◽  
Lee W. Riley ◽  
Eva Harris
Keyword(s):  
Sequence Analysis ◽  
Dengue Virus ◽  
Restriction Site ◽  
Epidemiological Studies ◽  
Site Specific ◽  
Specific Pcr ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Dengue Virus Serotypes ◽  
Dengue Virus Serotype 1

We previously reported a simple subtyping method, restriction site-specific PCR (RSS-PCR), for dengue virus serotypes 2 and 3; here we describe its application for subtyping dengue virus serotypes 1 and 4. Three major RSS-PCR types were observed for dengue virus serotype 1 and two types were observed for dengue virus serotype 4, in agreement with previous strain classifications based on sequence analysis. Because of its simplicity, this method is amenable to rapid subtyping and application to epidemiological studies of dengue in countries where dengue is endemic.

scholarly journals Complete Genome Sequence Analysis of an Imported Dengue Virus Serotype 1 Strain from Myanmar

2018 ◽  
Vol 6 (27) ◽  
Author(s):  
Zhaoping Zeng ◽  
Jiandong Shi ◽  
Xiaofang Guo ◽  
Ling Mo ◽  
Ningzhu Hu ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Genome Sequence Analysis ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Complete Genome Sequence Analysis ◽  
Dengue Virus Serotype 1

It has been determined that recent dengue virus epidemics in Yunnan, China, originated from Southeast Asian strains. Here, we report the first complete genome sequence and molecular characterization of the imported dengue virus serotype 1 strain YNPE1.

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