Theoretic coverage of heptavalent pneumococcal conjugate vaccine in the prevention of community-acquired pneumonia in children in Italy

Vaccine ◽  
2003 ◽  
Vol 21 (21-22) ◽  
pp. 2704-2707 ◽  
Author(s):  
Susanna Esposito ◽  
Dace V. Madore ◽  
Stefania Gironi ◽  
Samantha Bosis ◽  
Silvia Tosi ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Community Acquired Pneumonia ◽  
Heptavalent Pneumococcal Conjugate Vaccine

The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquired pneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan

2015 ◽  
Vol 144 (3) ◽  
pp. 494-506 ◽  
Author(s):  
S. NAITO ◽  
J. TANAKA ◽  
K. NAGASHIMA ◽  
B. CHANG ◽  
H. HISHIKI ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Odds Ratio ◽  
Rate Ratio ◽  
Pneumococcal Pneumonia ◽  
Incidence Rate Ratio ◽  
Multidrug Resistant ◽  
Community Acquired Pneumonia ◽  
Heptavalent Pneumococcal Conjugate Vaccine ◽  
The Impact

SUMMARYHeptavalent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2010. We investigated the impact of PCV7 on childhood community-acquired pneumonia (CAP) and pneumococcal pneumonia (PP). Children aged <5 years living in Chiba city, Japan, who were admitted to hospitals were enrolled to estimate the incidence of CAP based on the mid-year population. PP was determined by the presence of Streptococcus pneumoniae in cultured blood and/or sputum samples of CAP patients. The incidence of CAP and S. pneumoniae isolated from PP patients was compared before (April 2008–March 2009) and after (April 2012–March 2013) the introduction of PCV7 immunization. The annual incidence of CAP was reduced [incidence rate ratio 0·81, 95% confidence interval (CI) 0·73–0·90]. When comparing post-vaccine with pre-vaccine periods, the odds ratio for PP incidence was 0·60 (95% CI 0·39–0·93, P = 0·024). PCV7-covered serotypes markedly decreased (66·6% in pre-vaccine vs. 15·6% in post-vaccine, P < 0·01), and serotypes 6C, 15A, 15C and 19A increased. Multidrug-resistant international clones in the pre-vaccine period (Spain6B-2/ST90, Taiwan19F-14/ST236) decreased, while Sweden15A-25/ST63 was the dominant clone in the post-vaccine period. A significant reduction in the incidence of both CAP hospitalizations and culture-confirmed PP of vaccine serotypes was observed at 2 years after PCV7 vaccination.

scholarly journals Safety and Immunogenicity of Heptavalent Pneumococcal Conjugate Vaccine Booster in Taiwanese Toddlers

2006 ◽  
Vol 105 (7) ◽  
pp. 542-549 ◽  
Author(s):  
Pei-Lan Shao ◽  
Po-Ren Hsueh ◽  
Chun-Yi Lu ◽  
Luan-Yin Chang ◽  
Fu-Yuan Huang ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Vaccine Booster ◽  
Heptavalent Pneumococcal Conjugate Vaccine
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