Glomerular Hypertrophy and Chronic Renal Failure in Focal .Segmental Glomerulosclerosis

1994 ◽  
Vol 23 (2) ◽  
pp. 237-241 ◽  
Author(s):  
Andrea Onetti Muda ◽  
Sandro Feriozzi ◽  
Giulio A. Cinotti ◽  
Tullio Faraggiana
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Focal Segmental Glomerulosclerosis ◽  
Glomerular Hypertrophy ◽  
Segmental Glomerulosclerosis

Focal Segmental Glomerulosclerosis and Progressive Renal Failure Associated with a Unilateral Kidney

PEDIATRICS ◽  
1984 ◽  
Vol 73 (6) ◽  
pp. 806-810 ◽  
Author(s):  
Paul S. Thorner ◽  
Gerald S. Arbus ◽  
David S. Celermajer ◽  
Reuben Baumal
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Focal Segmental Glomerulosclerosis ◽  
Unilateral Nephrectomy ◽  
Critical Number ◽  
Progressive Renal Failure ◽  
The Third ◽  
Persistent Proteinuria ◽  
Segmental Glomerulosclerosis

Persistent proteinuria, chronic renal failure, and focal segmental glomerulosclerosis developed in three children with solitary kidneys. Two of these children were born with unilateral kidneys. The third had bilateral reflux and underwent a unilateral nephrectomy and reimplantation of the remaining ureter; persistent proteinuria developed 7 years later. It is postulated that hyperperfusion of a critical number of glomeruli during childhood may be the mechanism responsible for the production of focal segmental glomerulosclerosis in these patients.

scholarly journals Analysis of Mutations in Alpha-Actinin 4 and Podocin Genes of Patients with Chronic Renal Failure Due to Sporadic Focal Segmental Glomerulosclerosis

Renal Failure ◽  
2003 ◽  
Vol 25 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Atsushi Komatsuda ◽  
Hideki Wakui ◽  
Nobuki Maki ◽  
Akihiro Kigawa ◽  
Hiroyuki Goto ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis

Metanephric Adenoma with Embryonal Hyperplasia of Bowman's Capsular Epithelium: Previously Unreported Association

2000 ◽  
Vol 3 (5) ◽  
pp. 472-478 ◽  
Author(s):  
Keshani de Silva ◽  
Vivienne Tobias ◽  
Gad Kainer ◽  
Bruce Beckwith
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Focal Segmental Glomerulosclerosis ◽  
Left Kidney ◽  
Bilateral Nephrectomy ◽  
Metanephric Adenoma ◽  
Histological Features ◽  
Segmental Glomerulosclerosis

We report a case of a 9-year-old boy with focal, segmental glomerulosclerosis who, following peritoneal dialysis, underwent renal transplantation and bilateral nephrectomy. The kidneys showed histological features of embryonal hyperplasia of Bowman's capsular epithelium, an uncommon lesion that is seen most often in patients with chronic renal failure who are being maintained on dialysis. In addition, a 1-cm tumor in the left kidney showed features of metanephric adenoma. Although both lesions are uncommon, they share many similarities on a morphological, immunohistochemical, and ultrastructural basis. This association has not been previously reported and may shed some light on the histogenesis of these recently described lesions.

scholarly journals Reversible glomerular hypertrophy in adult patients with primary focal segmental glomerulosclerosis.

1997 ◽  
Vol 8 (11) ◽  
pp. 1668-1678
Author(s):  
K Nishimoto ◽  
H Shiiki ◽  
T Nishino ◽  
H Uyama ◽  
M Iwano ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Focal Segmental Glomerulosclerosis ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Cell Number ◽  
Glomerular Hypertrophy ◽  
Control Subjects ◽  
Segmental Glomerulosclerosis ◽  
The Mean ◽  
Glomerular Tuft

The present study was performed to assess the pathogenetic role of glomerular hypertrophy in patients with primary focal segmental glomerulosclerosis (FSGS). We studied 14 patients with FSGS by morphometry. In seven patients, minimal change nephrotic syndrome (MCNS) was diagnosed on the first renal biopsy, but FSGS was diagnosed on the second biopsy (MCNS-FSGS group). Seven other patients with FSGS on the first biopsy underwent second biopsies while in remission (FSGS-R group). Biopsy results were compared with biopsies from 10 patients with MCNS and seven control subjects. Nonsclerotic glomeruli were examined. The mean glomerular tuft area, whole glomerular area, and number of mesangial cells were significantly increased in both biopsies from the MCNS-FSGS group and in the first biopsies obtained during the nephrotic stage of the FSGS-R group, compared with control subjects and patients with MCNS. Biopsies from FSGS patients in remission showed that the mean glomerular tuft area and number of mesangial cells were significantly decreased. The fractional extracellular matrix area (extracellular matrix area/glomerular tuft area) and mesangial cell density (mesangial cell number/glomerular tuft area) in FSGS during both nephrotic and remission stages were the same as those in control subjects and patients with MCNS. The present study suggests that glomerular hypertrophy precedes the development of glomerulosclerosis in FSGS and is reversible when patients are in remission. These features support the pathogenetic importance of glomerular hypertrophy in patients with primary FSGS.

scholarly journals Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Akihito Sannomiya ◽  
Toru Murakami ◽  
Ichiro Koyama ◽  
Kosaku Nitta ◽  
Ichiro Nakajima ◽  
...  
Keyword(s):  
Renal Failure ◽  
Kidney Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Ldl Apheresis ◽  
Segmental Glomerulosclerosis ◽  
Living Related ◽  
Observation Period

Background. Focal segmental glomerulosclerosis (FSGS) often develops rapidly and frequently progresses to renal failure, while the recurrence rate after kidney transplantation is 20–50%. We performed low-density lipoprotein (LDL) apheresis before kidney transplantation in FSGS patients to prevent recurrence. Methods. Five adult patients with chronic renal failure due to FSGS undergoing living related donor kidney transplantation were investigated retrospectively. LDL apheresis was done 1-2 times before transplantation. Postoperative renal function and recurrence of FSGS were assessed. Results. The patients were two men and three women aged 24 to 41 years. The observation period ranged from 60 days to 22 months. Preoperative LDL apheresis was performed once in one patient and twice in four patients. Blood LDL cholesterol levels were normal before LDL apheresis and remained normal both after LDL apheresis and after kidney transplantation. Additional LDL apheresis was performed once in one patient with mild proteinuria after transplantation. The renal graft survived in all patients and there was no evidence of recurrent FSGS. Conclusions. Although the observation period was short, FSGS did not recur in all 5 patients receiving preoperative LDL apheresis. These results suggest that LDL apheresis can be effective in preventing recurrence of FSGS after kidney transplantation.

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