Boxed Warning Added to Diabetic Ulcer Treatment

<p><em>Diabetes mellitus (DM) is a group of metabolic diseases characterized by high levels of glucose in the blood (hyperglycemia) that occurs due to impaired insulin secretion, decreased insulin action, or a result of both. Self-acceptance is the ability and desire of individuals to live with all the characteristics themselves against diabetes mellitus. This study aims to determine the effectiveness of diabetic ulcer treatment on self-acceptance of Type II Diabetes Mellitus patients at Asri Wound Care Center Medan. This study uses quantitative research methods with a quasi-experimental design through the one-group pretest-posttest design approach. The population in the study as many as 20 people, with sampling techniques using saturated sampling, the research sample amounted to 20 people. This study uses a nonparametric statistical test that is paired t-test. The results of research on self-acceptance of patients with type II diabetes mellitus before treatment of diabetic ulcers showed that the majority of self-acceptance was not good, and the self-acceptance of patients after treatment of diabetic ulcers obtained the majority of good self-acceptance. The effectiveness of diabetic ulcer treatment on self-acceptance of type II diabetes mellitus patients obtained significance value p-value = 0.00 (p-value <0.05) then H0 was rejected. This means that there are differences in self-acceptance of type II Diabetes mellitus patients before and after diabetic ulcer treatment at Asri Wound Care Center Medan. Future researchers are expected to discuss more deeply about the factors that affect the self-acceptance of diabetes mellitus patients who are undergoing treatment for diabetic ulcers.</em></p>

Download Full-text

Plantar pressure in off-loading devices used in diabetic ulcer treatment

Wound Repair and Regeneration ◽

10.1111/j.1524-475x.2005.00075.x ◽

2005 ◽

Vol 13 (6) ◽

pp. 537-542 ◽

Cited By ~ 41

Author(s):

BENN J. BEUKER ◽

ROBERT W. DEURSEN ◽

PATRICIA PRICE ◽

ERIK A. MANNING ◽

JEFF G. BAAL ◽

...

Keyword(s):

Plantar Pressure ◽

Diabetic Ulcer ◽

Loading Devices ◽

Ulcer Treatment

Download Full-text

Treating hard-to-heal ulcers: biocellulose with nanosilver compared with silver sulfadiazine

Journal of Wound Care ◽

10.12968/jowc.2020.29.sup12.s33 ◽

2020 ◽

Vol 29 (Sup12) ◽

pp. S33-S37

Author(s):

Orawan Chansanti ◽

Atthawit Mongkornwong

Keyword(s):

Demographic Data ◽

Good Choice ◽

Silver Sulfadiazine ◽

Randomised Control Trial ◽

Control Group ◽

Diabetic Ulcer ◽

Diabetic Ulcers ◽

Group Control Group ◽

Experimental Group ◽

Ulcer Treatment

Objective: Controlling infection and promoting healing should be the aims of hard-to-heal diabetic ulcer treatment, along with improving a patient's general condition and their blood sugar control. Many hard-to-heal diabetic ulcers present with cavities, tracks or a combination of these. There is a new biocellulose (with a nanosilver dressing) which has the ability to contour around and conform to the irregular surface of a wound bed. The purpose of this study was to evaluate its efficacy compared with a silver sulfadiazine cream, for hard-to-heal diabetic ulcer treatment. Methods: In this randomised control trial, patients with hard-to-heal diabetic ulcers were divided into two equal-sized groups: treatment with the biocellulose with blue nanosilver (experimental group), and treatment with silver sulfadiazine cream group (control group). Cotton gauze was used as the secondary dressing for both groups. Demographic data, wound size, wound classification, wound photography and bacterial cultures were recorded at the beginning of the study. Wounds were debrided as necessary. Dressings were changed twice daily in the control group, and every three days in the experimental group. Results: A total of 20 patients took part in the study (10 patients in each group). The highest mean wound healing rates were 91.4% in the experimental group and 83.9% in the control group. No wound infections or adverse effects from the dressings were detected in either group. Conclusion: In this study, biocellulose with blue nanosilver adapted well to the wound bed. Wound reduction was greater in the experimental group than the control group. Biocellulose with blue nanosilver could therefore be a good choice for hard-to-heal diabetic ulcer treatment, due to its good healing rates and minimal care requirements.

Download Full-text

Nano-Oxy: Diabetic ulcer treatment using oxygen nanoparticles concept as innovation in reducing amputation rates and antibiotics usage

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2022.13.1.0031 ◽

2022 ◽

Vol 13 (1) ◽

pp. 309-316

Author(s):

Shofiuddin Al Mufid ◽

Naufal Achmad Tsany Daffa ◽

Dedy Firmansyah ◽

Octaviana Galuh Pratiwi ◽

Innas Safira Putri ◽

...

Keyword(s):

Oxygen Therapy ◽

Activation Mechanism ◽

Limb Amputation ◽

Target Cells ◽

Diabetic Patients ◽

Diabetic Ulcer ◽

Diabetic Ulcers ◽

Ulcer Therapy ◽

Chronic Hyperglycemia ◽

Ulcer Treatment

Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia caused by defects in insulin secretion, insulin reactions, or both. More than one third of diabetic patients have complications in the form of diabetic ulcers, and half are infected, and 15% of these infections require limb amputation. High cost expenditure and risks of microbial resistance to antibiotics also adds the complexity of the problem. The purpose of this literature review is to offer Nano-Oxy, using oxygen in nanoparticle size, as an alternative diabetic ulcer treatment. Literature searching was conducted through online search method. Oxygen therapy has been widely used to treat diabetic ulcers, including hyperbaric oxygen therapy (HOT) and topical oxygen therapy (TOT). Both of them have good results on diabetic ulcer therapy. Oxygen can act as an antimicrobial agent through the activation mechanism of neutrophils and macrophages which play a role in phagocytosis process and ROS regeneration. Nano-Oxy has advantages than the previous therapy, such as it does not cause barotrauma, oxygen poisoning, and low risk of burning. The mechanism of how Nano-Oxy works is similar with the Micro-nanobubbles (MNBs) concept. The negatively charged surface of MNBs can prevent them from aggregating, attracts particles, and help remove debris. MNBs also generate free radicals while shrinking in water, which contribute to its antibacterial effect. In addition, Nano-oxygen technology can be applied externally, but still have effect on the intended target cells. Therefore, Nano-oxygen can be used as a diabetic ulcer therapy to replace the role of antibiotics.

Download Full-text