A large yolk sac may be important in the early diagnosis of gestational trophoblastic disease: a case report

Due to the HIV pandemic, the chances of finding gynecological malignancies in HIV-infected women are increased. This poses management and ethical dilemmas as the treatment for such malignancies are likely to further decrease their immunity. Gestational trophoblastic disease occurs predominantly among young women and has excellent response to chemotherapy. However, such therapy is not possible if their immunity (CD4 counts) is markedly depressed. The patient described presented with persistent molar pregnancy and had low CD4 count. She was given antiretroviral therapy and once the CD4 count had risen to acceptable levels cytotoxic chemotherapy was administered. She received a total of 13 cycles of chemotherapy with no significant untoward effects. After a 6-month follow-up period the patient was well with a negative serum βHCG level and CD4 count above 200. We conclude that HIV-infected women with gestational trophoblastic disease may be safely treated with cytotoxic chemotherapy provided anti-retroviral therapy is concurrently administered to boost immunity.

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Persistent gestational trophoblastic disease following ovarian molar pregnancy: A case report of a rare entity with review of the literature

Clinical Case Reports ◽

10.1002/ccr3.4738 ◽

2021 ◽

Vol 9 (9) ◽

Author(s):

Bibechan Thapa ◽

Meenu Maharjan ◽

Heera Tuladhar

Keyword(s):

Case Report ◽

Gestational Trophoblastic Disease ◽

Molar Pregnancy ◽

Rare Entity ◽

Review Of The Literature ◽

Trophoblastic Disease

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Spontaneous regression of quiescent gestational trophoblastic disease after pregnancy: a case report

BMC Women s Health ◽

10.1186/s12905-019-0794-2 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Yoshiyuki Okada ◽

Shingo Miyamoto ◽

Takashi Mimura ◽

Tetsuya Ishikawa ◽

Akihiko Sekizawa ◽

...

Keyword(s):

Case Report ◽

Spontaneous Regression ◽

Gestational Trophoblastic Disease ◽

Trophoblastic Disease

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P29.06: Diagnosis and follow-up of uterine arteriovenous fistula associated with gestational trophoblastic disease by three-dimensional ultrasound: a case report

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.4747 ◽

2007 ◽

Vol 30 (4) ◽

pp. 561-562

Author(s):

P. M. Nowak ◽

L. M. M. Nardozza ◽

S. Y. Sun ◽

M. F. Vieira ◽

G. A. R. Lobo ◽

...

Keyword(s):

Case Report ◽

Arteriovenous Fistula ◽

Three Dimensional ◽

Gestational Trophoblastic Disease ◽

Trophoblastic Disease

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Perimenopausal giant hydatidiform mole complicated with preeclampsia and hyperthyroidism: A case report and literature review

Open Medicine ◽

10.1515/med-2021-0315 ◽

2021 ◽

Vol 16 (1) ◽

pp. 1038-1042

Author(s):

Yan Wan ◽

Guoqing Jiang ◽

Ying Jin ◽

Zengping Hao

Keyword(s):

Case Report ◽

Literature Review ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Hydatidiform Mole ◽

Gestational Trophoblastic Disease ◽

Optimal Treatment ◽

Perimenopausal Woman ◽

Trophoblastic Disease ◽

Reproductive Females

Abstract Gestational trophoblastic disease (GTD) commonly occurs in reproductive females, but is extremely rare in perimenopausal females. In this study, we reported a case of hydatidiform mole in a 48-year-old perimenopausal female admitted due to a giant uterine mass of 28 weeks’ gestational size. The serum human chorionic gonadotropin (HCG) level ranged from 944 to 1,286 mIU/mL before treatments. The signs of preeclampsia and hyperthyroidism were relatively prominent. Hysterectomy was performed and chemotherapy was scheduled when the serum HCG level remained at a plateau, about 528 mIU/mL. The symptoms of preeclampsia and hyperthyroidism were relieved after treatment. Accordingly, we concluded that GTD could occur in perimenopausal woman and hysterectomy usually is the optimal treatment.

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Clinical and radiological correlations in patients with gestational trophoblastic disease

Radiologia Brasileira ◽

10.1590/0100-3984.2015.0073 ◽

2016 ◽

Vol 49 (4) ◽

pp. 241-250 ◽

Cited By ~ 13

Author(s):

Lana de Lourdes Aguiar Lima ◽

Raphael Câmara Medeiros Parente ◽

Izildinha Maestá ◽

Joffre Amim Junior ◽

Jorge Fonte de Rezende Filho ◽

...

Keyword(s):

Early Diagnosis ◽

Hyperemesis Gravidarum ◽

Gestational Trophoblastic Disease ◽

Reproductive Age ◽

Therapy Regimen ◽

Trophoblastic Disease ◽

Appropriate For Gestational Age ◽

Serious Disease ◽

Asymptomatic Phase ◽

Cure Rates

Abstract Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early preeclampsia; hyperemesis gravidarum; and hyperthyroidism. Currently, with early diagnosis made by ultrasound, most patients are diagnosed while the disease is still in the asymptomatic phase. In cases of progression to trophoblastic neoplasia, staging-typically with Doppler flow studies of the pelvis and chest X-ray, although occasionally with computed tomography or magnetic resonance imaging-is critical to the choice of an appropriate antineoplastic therapy regimen. Because it is an unusual and serious disease that affects women of reproductive age, as well as because its appropriate treatment results in high cure rates, it is crucial that radiologists be familiar with gestational trophoblastic disease, in order to facilitate its early diagnosis and to ensure appropriate follow-up imaging.

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