Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder

BackgroundWe have previously reported the Val66Met and GT(n) repeat polymorphisms of the brain-derived neurotrophic factor (BDNF) gene to be associated with bipolar disorder. However, these findings have not been replicated consistently.AimsTo dissect the association of the BDNF gene with bipolar disorder by examining additional markers at the DNA level and by testing the illness categories of bipolar disorder I and II and rapid cycling.MethodWe performed a family-based association study and haplotype analyses with 312 nuclear families using four single nucleotide polymorphisms (SNPs) and the Val66Met and GT(n) repeat polymorphisms.ResultsThe SNPs hCVI1592756 and rs2049045, the Val66Met and GT(n) were significantly associated with bipolar disorder using transmission disequilibrium analyses (P=0.02, 0.009, 0.001 and 0.008 respectively). The effect at these markers was mainly driven by the rapid-cycling patients.ConclusionsWithin bipolar disorder, variation in the BDNF gene appears to predict risk for developing rapid cycling according to DSM–IV. Incorporating this clinical sub-phenotyping into other studies of the BDNF gene may help to resolve some of the inconsistencies reported thus far concerning BDNF and bipolar disorder.

Download Full-text

A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity

Molecular Psychiatry ◽

10.1038/sj.mp.4001822 ◽

2006 ◽

Vol 11 (7) ◽

pp. 695-703 ◽

Cited By ~ 50

Author(s):

T Okada ◽

R Hashimoto ◽

T Numakawa ◽

Y Iijima ◽

A Kosuga ◽

...

Keyword(s):

Bipolar Disorder ◽

Neurotrophic Factor ◽

Transcriptional Activity ◽

Brain Derived Neurotrophic Factor ◽

Bdnf Gene ◽

Polymorphic Region ◽

The Brain

Download Full-text

Impact of a haplotype (Val66Met) in the brain derived neurotrophic factor (BDNF) gene on serotonergic neurotransmission as reflected by the loudness dependence of auditory evoked potentials

Klinische Neurophysiologie ◽

10.1055/s-0030-1250899 ◽

2010 ◽

Vol 41 (01) ◽

Author(s):

C Norra ◽

C Schumacher ◽

I Giegling ◽

H Assion ◽

P Mavrogiorgou ◽

...

Keyword(s):

Evoked Potentials ◽

Neurotrophic Factor ◽

Auditory Evoked Potentials ◽

Brain Derived Neurotrophic Factor ◽

Bdnf Gene ◽

Serotonergic Neurotransmission ◽

Loudness Dependence ◽

The Brain

Download Full-text

An association study of the brain-derived neurotrophic factor Val66Met polymorphism and amphetamine response

American Journal of Medical Genetics Part B Neuropsychiatric Genetics ◽

10.1002/ajmg.b.30327 ◽

2006 ◽

Vol 141B (6) ◽

pp. 576-583 ◽

Cited By ~ 31

Author(s):

Brody A. Flanagin ◽

Edwin H. Cook ◽

Harriet de Wit

Keyword(s):

Association Study ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Val66met Polymorphism ◽

The Brain

Download Full-text

Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3112 ◽

2021 ◽

Vol 17 (7) ◽

pp. 1371-1379

Author(s):

Di Liu ◽

Ying Li ◽

Jiechen Liu ◽

Zhiyuan Shen ◽

Fengying Wang ◽

...

Keyword(s):

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Systemic Response ◽

Periodontal Tissue ◽

Trigeminal Nucleus ◽

Bdnf Gene ◽

Dental Tissue ◽

Injury And Repair ◽

Activity Dependent ◽

The Brain

Occlusal trauma (OT), by causing periodontal tissue damage, can activate and enhance the activity of the peripheral and central nervous system (CNS) neuropeptides. The brain-derived neurotrophic factor (BDNF) gene is activity-dependent and exhibits marked alterations, characterized by protection against injury and repair. Our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in BDNF activity in the local periodontal tissue, the primary sensory neurons-Vc, and the hippocampus, suggesting systemic impairment. BDNF serves a more positive and enduring trauma protection and repair function in Vc compared to that in local dental tissue.

Download Full-text