Induction of ornithine decarboxylase mRNA in transient focal cerebral ischemia in the rat

1997 ◽  
Vol 239 (2-3) ◽  
pp. 69-72 ◽  
Author(s):  
Riitta Keinänen ◽  
Susanna Miettinen ◽  
Juha Yrjänheikki ◽  
Jari Koistinaho
Keyword(s):  
Cerebral Ischemia ◽  
Ornithine Decarboxylase ◽  
Focal Cerebral Ischemia ◽  
Transient Focal Cerebral Ischemia

scholarly journals Ornithine Decarboxylase Knockdown Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

2001 ◽  
Vol 21 (8) ◽  
pp. 945-954 ◽  
Author(s):  
Raghavendra Vemuganti L. Rao ◽  
Aclan Dogan ◽  
Kellie K. Bowen ◽  
Robert J. Dempsey
Keyword(s):  
Cerebral Ischemia ◽  
Ornithine Decarboxylase ◽  
Neuronal Damage ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Artery Occlusion ◽  
Motor Deficits ◽  
Spontaneously Hypertensive ◽  
Protein Levels ◽  
Transient Focal Cerebral Ischemia

Transient cerebral ischemia leads to increased expression of ornithine decarboxylase (ODC). Contradicting studies attributed neuroprotective and neurotoxic roles to ODC after ischemia. Using antisense oligonucleotides (ODNs), the current study evaluated the functional role of ODC in the process of neuronal damage after transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats. Transient MCAO significantly increased the ODC immunoreactive protein levels and catalytic activity in the ipsilateral cortex, which were completely prevented by the infusion of antisense ODN specific for ODC. Transient MCAO in rats infused with ODC antisense ODN increased the infarct volume, motor deficits, and mortality compared with the sense or random ODN-infused controls. Results of the current study support a neuroprotective or recovery role, or both, for ODC after transient focal ischemia.

Proteomic analysis of rat plasma following transient focal cerebral ischemia

2011 ◽  
Vol 5 (6) ◽  
pp. 837-846 ◽  
Author(s):  
Ruoli Chen ◽  
Iolanda Vendrell ◽  
Carl PC Chen ◽  
Diana Cash ◽  
Kim Galley O’Toole ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Proteomic Analysis ◽  
Focal Cerebral Ischemia ◽  
Rat Plasma ◽  
Transient Focal Cerebral Ischemia

Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats

2009 ◽  
Vol 16 (5) ◽  
pp. 693-697 ◽  
Author(s):  
M. Ozgur Taskapilioglu ◽  
Tulin Alkan ◽  
Bulent Goren ◽  
Kudret Tureyen ◽  
Soner Sahin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Protective Effects ◽  
Transient Focal Cerebral Ischemia
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