Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells

Neuroscience ◽  
1998 ◽  
Vol 83 (2) ◽  
pp. 363-372 ◽  
Author(s):  
C Apostolides ◽  
E Sanford ◽  
M Hong ◽  
I Mendez
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Graft Survival ◽  
Neurotrophic Factor ◽  
Dopaminergic Cells

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line—derived neurotrophic factor in patients with Parkinson's disease

2000 ◽  
Vol 92 (5) ◽  
pp. 863-869 ◽  
Author(s):  
Ivar Mendez ◽  
Alain Dagher ◽  
Murray Hong ◽  
Adam Hebb ◽  
Paula Gaudet ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Graft Survival ◽  
Neurotrophic Factor ◽  
Storage Period ◽  
Content Type ◽  
Dopaminergic Cells ◽  
Positron Emission

✓ The authors have studied the ability of glial cell line—derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting.

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