Glial cell line-derived neurotrophic factor expression and promoter methylation in a rat model of alcohol addiction

2019 ◽  
Author(s):  
H Maier ◽  
M Neyazi ◽  
A Neyazi ◽  
T Hillemacher ◽  
S Bleich ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Promoter Methylation ◽  
Neurotrophic Factor ◽  
Alcohol Addiction ◽  
Factor Expression

Autoregulation of glial cell line‐derived neurotrophic factor expression: implications for the long‐lasting actions of the anti‐addiction drug, Ibogaine

2006 ◽  
Vol 20 (13) ◽  
pp. 2420-2422 ◽  
Author(s):  
Dao‐Yao He ◽  
Dorit Ron ◽  
Dao‐Yao He ◽  
Dorit Ron
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Factor Expression ◽  
Addiction Drug

Early transplantation of an encapsulated glial cell line—derived neurotrophic factor—producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease

2005 ◽  
Vol 102 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Takao Yasuhara ◽  
Tetsuro Shingo ◽  
Kenichiro Muraoka ◽  
Kazuki Kobayashi ◽  
Akira Takeuchi ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor ◽  
Dopaminergic Neurons ◽  
Neuroprotective Effects ◽  
Content Type ◽  
Glial Proliferation ◽  
Fine Print

Object. Glial cell line—derived neurotrophic factor (GDNF) has been shown to confer neuroprotective effects on dopaminergic neurons. The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)—treated dopaminergic neurons in vitro and in vivo. Methods. First, the authors examined how 1, 10, or 100 ng/ml of GDNF, administered to cells 24 hours before, simultaneously with, or 2 or 4 hours after 6-OHDA was added, affected dopaminergic neurons. In a primary culture of E14 murine ventral mesencephalic neurons, earlier treatment with the higher dosage of GDNF suppressed 6-OHDA—induced loss of dopaminergic neurons better than later treatment. Next, the authors examined whether continuous infusion of GDNF at earlier time points would demonstrate a greater neuroprotective effect in a rat model of Parkinson disease (PD). They established a human GDNF-secreting cell line, called BHK-GDNF, and encapsulated the cells into hollow fibers. The encapsulated cells were unilaterally implanted into the striatum of adult rats 1 week before; simultaneously with; or 1, 2, or 4 weeks after 6-OHDA was given to induce lesions of the same striatum. With the earlier transplantation of a BHK-GDNF capsule, there was a significant reduction in the number of amphetamine-induced rotations displayed by the animals. Rats that had received earlier implantation of BHK-GDNF capsules displayed more tyrosine hydroxylase—positive neurons in the substantia nigra pars compacta and a tendency for glial proliferation in the striatum. Conclusions. These neuroprotective effects may be related to glial proliferation and signaling via the GDNF receptor α1. The results of this study support a role for this grafting technique in the treatment of PD.

Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Aleksandra Glavaski-Joksimovic ◽  
Tamas Virag ◽  
Thomas A. Mangatu ◽  
Michael McGrogan ◽  
Xue Song Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor ◽  
Genetically Modified ◽  
Human Bone ◽  
Human Bone Marrow

scholarly journals An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease

2010 ◽  
Vol 30 (49) ◽  
pp. 16469-16474 ◽  
Author(s):  
J. Laganiere ◽  
A. P. Kells ◽  
J. T. Lai ◽  
D. Guschin ◽  
D. E. Paschon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Zinc Finger ◽  
Rat Model ◽  
Neurotrophic Factor ◽  
Zinc Finger Protein ◽  
Factor Gene ◽  
Protein Activator ◽  
Finger Protein

Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease

2005 ◽  
Vol 134 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Jie-Sheng Zheng ◽  
Ling-Ling Tang ◽  
Shu-Sen Zheng ◽  
Ren-Ya Zhan ◽  
Yong-Qing Zhou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor

Enhancement of Glial Cell Line-Derived Neurotrophic Factor Expression in Rat Adrenal Glands by Toluene Exposure

2000 ◽  
Vol 32 (08) ◽  
pp. 301-305 ◽  
Author(s):  
T. Gotohda ◽  
I. Tokunaga ◽  
S. Kubo ◽  
K. Morita
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Adrenal Glands ◽  
Factor Expression ◽  
Toluene Exposure
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