Gestational Squamous Cell Carcinoma of the Breast: An Unusual Mammary Tumor Associated With Aggressive Clinical Course

1997 ◽  
Vol 193 (11-12) ◽  
pp. 783-787 ◽  
Author(s):  
Fabrizio Zanconati ◽  
Micaela Zanella ◽  
Giovanni Falconieri ◽  
Luigi Di Bonito
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mammary Tumor ◽  
Clinical Course ◽  
Carcinoma Of The Breast ◽  
Aggressive Clinical Course

scholarly journals Metaplastic squamous cell carcinoma of the breast: A case report and literature review

2016 ◽  
Vol 62 (7) ◽  
pp. 618-621 ◽  
Author(s):  
Luciana Graziano ◽  
Paschoal Graziano Filho ◽  
Almir Galvão Vieira Bitencourt ◽  
Daniel Bernal Soto ◽  
Alexandre Hiro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Course ◽  
Squamous Cell Carcinomas ◽  
Metaplastic Carcinoma ◽  
Breast Adenocarcinoma ◽  
Imaging Studies ◽  
Carcinoma Of The Breast ◽  
Average Size

Summary Metaplastic tumors are rare and represent a heterogeneous group of neoplasms showing dominant areas of non-glandular differentiation. Etiology and pathogenesis of this type of lesion in the breast is uncertain. The most common sources of metastatic squamous cell carcinoma of the breast are lung, esophagus, cervix, and urinary bladder. Squamous cell carcinomas may present clinically with inflammation and average size greater than breast adenocarcinoma. As for imaging studies, mammography shows no typical findings and ultrasound can show a complicated cyst or an inflammatory process, among the differential diagnoses. Therefore, knowing this pathological entity, its clinical course and imaging findings is important to safely treat such a rare and aggressive disease. We herein report a case of metaplastic carcinoma, squamous subtype, diagnosed by core needle biopsy.

scholarly journals Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

2010 ◽  
Vol 25 (6) ◽  
pp. 513-517 ◽  
Author(s):  
Roseana de Almeida Freitas ◽  
Ericka Janine Dantas Silveira ◽  
João Paulo Borges da Silveira ◽  
Fabyanne Mazutti da Silva ◽  
Rivadávio Fernandes Batista de Amorim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Quantitative Analysis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tumor Metastasis ◽  
Clinical Course ◽  
Negative Score ◽  
Positive Score ◽  
Aggressive Clinical Course

PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis. METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue.

scholarly journals Primary squamous cell carcinoma of the breast in a young female‐ A rare ailment

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Suraj Shrestha ◽  
Prafulla Shakya ◽  
Sanjeev Kharel ◽  
Hari Prasad Dhakal ◽  
Moushami Singh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Young Female ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

Co-expression of EGFR and CK5/6 in primary squamous cell carcinoma of the breast

2014 ◽  
Vol 31 (9) ◽  
Author(s):  
Jin Wang ◽  
Xinke Zhang ◽  
Jiehua He ◽  
Mingtian Yang ◽  
Jun Tang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

PRIMARY SQUAMOUS CELL CARCINOMA OF THE BREAST

2003 ◽  
Vol 13 (Suppl 1) ◽  
pp. 84.2-84
Author(s):  
K. Brack ◽  
W. A.A. Tjalma ◽  
P. Ramaeckers ◽  
E. Van Marck
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

2018 ◽  
Vol 72 (4) ◽  
pp. 285-294 ◽  
Author(s):  
Melanie Boxberg ◽  
Christine Bollwein ◽  
Korinna Jöhrens ◽  
Peer-Hendrik Kuhn ◽  
Bernhard Haller ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interobserver Reliability ◽  
Training Session ◽  
Nest Size ◽  
Grading System ◽  
Tumour Entity ◽  
Aggressive Clinical Course ◽  
Tumour Budding

AimsSquamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and cell nest size which outperforms WHO based grading algorithms currently in use. The aim of our study was to probe for interobserver and intraobserver reliability of this novel grading system.Methods108 OSCC were retrospectively scored according to the proposed grading scheme by three independent pathologists—two experienced head and neck pathologists and one pathologist in training—blinded to each other’s scoring results.ResultsThe Cohen’s Kappa (κ) values for concordance rates between experienced pathologists were κ=0.97 for the overall grade, κ=0.97 for budding activity and κ=0.91 for cell nest size, indicating a strong interobserver reliability of our proposed grading system. Initial interobserver agreement was markedly lower with the pathologist in training (κ=0.55 for overall grade) but improved significantly after a training session (κ=0.87 for overall grade). Intraobserver concordance was high (κ=0.95 for overall grade), indicating a high reproducibility of the algorithm.ConclusionsIn conclusion, our study indicates that OSCC grading based on our proposed novel scheme yields an excellent inter-reader and intrareader agreement, further supporting the suitability of this grading system for routine pathological practice.

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