scholarly journals Metaplastic squamous cell carcinoma of the breast: A case report and literature review

2016 ◽  
Vol 62 (7) ◽  
pp. 618-621 ◽  
Author(s):  
Luciana Graziano ◽  
Paschoal Graziano Filho ◽  
Almir Galvão Vieira Bitencourt ◽  
Daniel Bernal Soto ◽  
Alexandre Hiro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Course ◽  
Squamous Cell Carcinomas ◽  
Metaplastic Carcinoma ◽  
Breast Adenocarcinoma ◽  
Imaging Studies ◽  
Carcinoma Of The Breast ◽  
Average Size

Summary Metaplastic tumors are rare and represent a heterogeneous group of neoplasms showing dominant areas of non-glandular differentiation. Etiology and pathogenesis of this type of lesion in the breast is uncertain. The most common sources of metastatic squamous cell carcinoma of the breast are lung, esophagus, cervix, and urinary bladder. Squamous cell carcinomas may present clinically with inflammation and average size greater than breast adenocarcinoma. As for imaging studies, mammography shows no typical findings and ultrasound can show a complicated cyst or an inflammatory process, among the differential diagnoses. Therefore, knowing this pathological entity, its clinical course and imaging findings is important to safely treat such a rare and aggressive disease. We herein report a case of metaplastic carcinoma, squamous subtype, diagnosed by core needle biopsy.

Rapidly Growing Squamous Cell Carcinoma

1999 ◽  
Vol 3 (4) ◽  
pp. 193-197 ◽  
Author(s):  
Elizabeth M. Billingsley ◽  
Nicole Davis ◽  
Klaus F. Helm
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rapid Growth ◽  
Average Duration ◽  
Squamous Cell Carcinomas ◽  
Viral Etiology ◽  
Immunosuppressed Patients ◽  
History Of ◽  
Average Size

Background: Squamous cell carcinoma (SCC) may present with a history of rapid growth. Although multiple subtypes have been described regarding histologic characteristics and etiology, the subset of rapidly growing squamous cell carcinomas (RGSCC) has not been described. Objective: To evaluate and describe the clinical and histologic characteristics of squamous cell carcinomas that grow rapidly. Methods: Recorded clinical data and biopsies of 26 lesions with a history of rapid growth and histologically diagnosed as SCC were reviewed. Results: Rapidly growing SCC occurred most commonly on the head and neck, followed by hands and extremities, and had an average duration of 7 weeks before diagnosis. The average size of the lesions was 1.29 cm and nearly 20% occurred in immunosuppressed patients. Conclusions: Some SCCs may grow rapidly. The reason for the rapid growth is not clear and several hypotheses are discussed including immunosuppression and viral etiology. These lesions should be treated aggressively as their behaviour and prognosis are not yet well described.

Papillary squamous cell carcinoma of the larynx

2001 ◽  
Vol 115 (2) ◽  
pp. 164-166 ◽  
Author(s):  
Cosme Ereño ◽  
José I López ◽  
José M. Sánchez ◽  
Francisco J. Bilbao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Course ◽  
Squamous Cell Carcinomas ◽  
Papillary Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Microscopic Features

A case of papillary squamous cell carcinoma of the larynx in a 50-year-old man is reported. The lesion was located in the supraglottic region and grossly presented a characteristic finger-like pattern of growth. The tumour pursued an indolent clinical course, and the patient is well and free of disease after 47 months of follow-up. The present paper recapitulates the macro- and microscopic features of this rare neoplasm and stresses its differential diagnosis with other exophytic squamous cell carcinomas of the region.

scholarly journals Primary squamous cell carcinoma of the breast in a young female‐ A rare ailment

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Suraj Shrestha ◽  
Prafulla Shakya ◽  
Sanjeev Kharel ◽  
Hari Prasad Dhakal ◽  
Moushami Singh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Young Female ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases

2021 ◽  
Vol 22 (6) ◽  
pp. 2831
Author(s):  
Ryan Bensen ◽  
John Brognard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Fate ◽  
Squamous Cell ◽  
Copy Number Gain ◽  
Genetic Alterations ◽  
Distal Portion ◽  
Squamous Cell Carcinomas ◽  
Cell Fate Decisions ◽  
Genetic Landscape

Squamous cell carcinomas of the lung, head and neck, esophagus, and cervix account for more than two million cases of cancer per year worldwide with very few targetable therapies available and minimal clinical improvement in the past three decades. Although these carcinomas are differentiated anatomically, their genetic landscape shares numerous common genetic alterations. Amplification of the third chromosome’s distal portion (3q) is a distinguishing genetic alteration in most of these carcinomas and leads to copy-number gain and amplification of numerous oncogenic proteins. This area of the chromosome harbors known oncogenes involved in squamous cell fate decisions and differentiation, including TP63, SOX2, ECT2, and PIK3CA. Furthermore, novel targetable oncogenic kinases within this amplicon include PRKCI, PAK2, MAP3K13, and TNIK. TCGA analysis of these genes identified amplification in more than 20% of clinical squamous cell carcinoma samples, correlating with a significant decrease in overall patient survival. Alteration of these genes frequently co-occurs and is dependent on 3q-chromosome amplification. The dependency of cancer cells on these amplified kinases provides a route toward personalized medicine in squamous cell carcinoma patients through development of small-molecules targeting these kinases.

Co-expression of EGFR and CK5/6 in primary squamous cell carcinoma of the breast

2014 ◽  
Vol 31 (9) ◽  
Author(s):  
Jin Wang ◽  
Xinke Zhang ◽  
Jiehua He ◽  
Mingtian Yang ◽  
Jun Tang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases

2021 ◽  
Vol 28 (3) ◽  
pp. 1886-1898
Author(s):  
Christian Flörke ◽  
Aydin Gülses ◽  
Christina-Randi Altmann ◽  
Jörg Wiltfang ◽  
Henning Wieker ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Patient Specific ◽  
Infiltration Depth ◽  
Tumor Grading ◽  
Node Metastases

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.

PRIMARY SQUAMOUS CELL CARCINOMA OF THE BREAST

2003 ◽  
Vol 13 (Suppl 1) ◽  
pp. 84.2-84
Author(s):  
K. Brack ◽  
W. A.A. Tjalma ◽  
P. Ramaeckers ◽  
E. Van Marck
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast

Invasive Squamous Cell Carcinoma with Osteomyelitis of the Foot

2015 ◽  
Vol 105 (4) ◽  
pp. 374-376
Author(s):  
Morteza Khaladj ◽  
Rose-Mary Mbibong ◽  
Nisha Shah ◽  
Ayesha Mohiuddin ◽  
Aqsa Siddiqui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chronic Wounds ◽  
Squamous Cell Carcinomas ◽  
Initial Presentation ◽  
Invasive Squamous Cell Carcinoma ◽  
The Sun ◽  
The Third

Squamous cell carcinomas are often seen on the sun-exposed areas of the skin and are rarely observed on the digits of the foot. However, there have been incidences of squamous cell carcinoma developing in the presence of chronic wounds with osteomyelitis, thus complicating the treatment. We present a patient with osteomyelitis who developed invasive squamous cell carcinoma of the third digit. We conclude that wounds with osteomyelitis may have underlying pathologic abnormalities that are not obvious on initial presentation.

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