95 Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients

1999 ◽  
Vol 45 (3) ◽  
pp. 196
Author(s):  
S. Johansson ◽  
H. Svensson ◽  
L.G. Larsson ◽  
J. Denekamp
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Radiation Injury ◽  
Postoperative Radiotherapy ◽  
Breast Cancer Patients

Adequate locoregional treatment for early breast cancer may prevent secondary dissemination.

1995 ◽  
Vol 13 (12) ◽  
pp. 2869-2878 ◽  
Author(s):  
R Arriagada ◽  
L E Rutqvist ◽  
A Mattsson ◽  
A Kramar ◽  
S Rotstein
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Distant Metastasis ◽  
Preoperative Radiotherapy ◽  
Postoperative Radiotherapy ◽  
Radical Mastectomy ◽  
Breast Cancer Surgery ◽  
Breast Cancer Patients

PURPOSE To analyze different events that determine event-free survival (EFS) in a randomized trial on adjuvant radiotherapy in early breast cancer patients with more than 15 years of follow-up evaluation. PATIENTS AND METHODS The trial included 960 patients with a unilateral, operable breast cancer. Surgery consisted of a modified radical mastectomy. The trial compared three arms, as follows: preoperative radiotherapy, postoperative radiotherapy, and no adjuvant treatment. Events were analyzed by a competing-risk approach. A proportional hazards multiple regression model was used to analyze the effects of radiotherapy on the risk of distant metastasis. Similar analyses were performed separately for node-negative [N(-)] and node-positive [N(+)] patients in the two groups that did not include preoperative radiotherapy. RESULTS Radiotherapy produced a fivefold decrease of the risk of local recurrence (P < .0001). In N(+) patients, postoperative radiotherapy decreased the risk of distant dissemination (relative risk, 0.63). When local recurrence was introduced in the model as a time-dependent covariate, this factor was predictive of distant dissemination (P < .0001) and nullified the effect of postoperative radiotherapy. This finding suggests that the decrease of distant metastases was related to the prevention of local recurrence. A similar effect was found in models that used overall survival as an end point. CONCLUSION This study shows that postmastectomy radiotherapy in N(+) breast cancer patients may decrease the distant metastasis rate by preventing local recurrences and thus avoiding secondary dissemination.

Brachial Plexopathy After Postoperative Radiotherapy of Breast Cancer Patients: A Long-Term Follow-up

2000 ◽  
Vol 39 (3) ◽  
pp. 373-382 ◽  
Author(s):  
Silvia Johansson ◽  
Hans Svensson ◽  
Lars-Gunnar Larsson ◽  
Juliana Denekamp
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Postoperative Radiotherapy ◽  
Brachial Plexopathy ◽  
Breast Cancer Patients ◽  
Long Term Follow Up

scholarly journals No clear effect of postoperative radiotherapy on survival of breast cancer patients with one to three positive nodes: a population-based study

2015 ◽  
Vol 26 (6) ◽  
pp. 1149-1154 ◽  
Author(s):  
A.E. Nordenskjöld ◽  
H. Fohlin ◽  
P. Albertsson ◽  
L.G. Arnesson ◽  
C. Chamalidou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Postoperative Radiotherapy ◽  
Population Based ◽  
Breast Cancer Patients ◽  
Population Based Study ◽  
Clear Effect

scholarly journals Postoperative radiotherapy after conservative surgery for early breast cancer: 5-year results

2004 ◽  
Vol 12 (1) ◽  
pp. 29-33
Author(s):  
Jasmina Mladenovic ◽  
Marko Dozic ◽  
Nenad Borojevic
Keyword(s):  
Breast Cancer ◽  
Survival Rate ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Systemic Therapy ◽  
Postoperative Radiotherapy ◽  
Breast Conserving Surgery ◽  
Breast Cancer Patients ◽  
Disease Free

BACKGROUND: Breast conserving surgery followed by postoperative radiotherapy, as alternative to radical mastectomy, has been accepted as an optimal method for loco- regional treatment of the majority of women with early stage of breast carcinoma. The aim of the study was to evaluate the results of postoperative radiotherapy after breast conserving surgery in the Institute for oncology and radiology of Serbia. METHODS: During the 3-year period, 109 breast cancer patients with stage I and II were treated with postoperative radiotherapy after breast conserving surgery. Ninety- four patients underwent quadrantectomy with axillary node dissection, and 15 patients underwent only tumorectomy. After surgery all patients received postoperative radiotherapy to the whole breast with tumor dose 50 Gy in 15 fractions every second day. In 52 patients radiotherapy was given to the regional lymphatics with tumor dose 45 Gy in 15 fractions every second day. Twenty-eight patients received a booster dose (10 Gy) to the tumor bed. Adjuvant systemic therapy was administered depending on the nodal involvement and steroid receptors content: 17 patients received adjuvant chemotherapy (CMF or FAC), 18 received adjuvant hormonal therapy (tamoxifen or ovarian ablation), and 6 patients received both chemo- and hormonotherapy. RESULTS: After median follow-up period of 62 months, there was no evidence of loco- regional recurrence in anyone of patients. Distant metastases occurred in 7 patients (6.4%) with median disease free interval of 27.6 months. At last follow-up 91 patients (83.4%) were alive, 4 patients (3.7%) were dead of disease, and the same number was dead of other causes. The 5-year overall survival rate was 92.9% and disease-free survival rate was 92.7%. CONCLUSION: According to our results the combined surgery and radiotherapy approach provides good local control of early breast cancer patients. Postoperative radiotherapy after breast conserving surgery with or without adjuvant systemic therapy has important role in adjuvant treatment of early breast cancer.

CT findings of acute radiation-induced pneumonitis in breast cancer

2021 ◽  
pp. 20200997
Author(s):  
Wonguen Jung ◽  
Sung Shine Shim ◽  
Kyubo Kim
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Postoperative Radiotherapy ◽  
Acute Radiation ◽  
Breast Cancer Patients ◽  
Ct Findings ◽  
Dose Volume ◽  
Radiation Induced ◽  
Grade 3

Objectives: To evaluate the computed tomography (CT) findings of acute radiation pneumonitis (RP) in breast cancer patients undergoing postoperative radiotherapy, and to analyze clinico-dosimetric factors associated with acute RP. Methods: Between 2015 and 2017, 61 patients with breast cancer who underwent follow-up chest CT at 3 months after radiotherapy were analyzed. The degree of acute RP on CT was evaluated by the change of extent and scoring system (grade 0, no RP; Grade 1, ground-glass opacities (GGOs); Grade 2, GGOs and/or consolidations; Grade 3, clear focal consolidation; Grade 4, dense consolidation). The dosimetric parameters were calculated from the dose-volume histogram of RT. Results: The acute RP on CT was scored as follows: grade 0, in 37.7%, Grade 1 in 13.1%, Grade 2 in 44.3%, and Grade 3 in 4.9%. The median extent of RP in patients with Grades 1 to 3 was 6.2 ml (range, 0.2–95.9). There were no clinico-dosimetric factors significantly associated with the presence of RP or its severity. One patient developed symptomatic RP. Conclusions: This study showed no correlation between acute RP and clinico-dosimetric factors, and acute RP based on CT findings were much more common than symptomatic RP. Advances in knowledge: CT findings of acute RP or extent of RP were not significantly related to clinico-dosimetric factors in breast cancer patients.

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