Dupuytren's disease, carpal tunnel syndrome, trigger finger, and diabetes mellitus

1995 ◽  
Vol 20 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Michel Chammas ◽  
Philippe Bousquet ◽  
Eric Renard ◽  
Jean-Luc Poirier ◽  
Claude Jaffiol ◽  
...  
2015 ◽  
Vol 21 (4) ◽  
pp. 178-185 ◽  
Author(s):  
Sebe Ioana Teona ◽  
I. Lascar ◽  
M. Valcu ◽  
B. Caraban ◽  
Colcigeanu Anca

Abstract Dupuytren’s contracture is a fibroproliferative disease whose etiology and pathophysiology are unclear and controversial. It is a connective tissue disorder, which takes part in the palmar’s fibromatosis category and has common characteristics with the healing process. Dupuytren’s disease is characterized by the flexion contracture of the hand due to palmar and digital aponevrosis. It generally affects the 4th digital radius, followed by the 5th one. Without surgery, it leads to functional impotence of those digital rays and/or hand. It is associated with other diseases and situational conditions like Peyronie’s disease, the Lederhose disease (plantar fibromatosis), Garrod’s digital knuckle-pads, diabetes, epilepsy, alcoholism, micro traumatisms, stenosing tenosynovitis and not the least with carpal tunnel syndrome. The carpal tunnel syndrome is a peripheral neuropathy with the incarceration of the median nerve at the ARC level, expressed clinically by sensory and motor disturbances in the distribution territory of the median nerve, which cause functional limitations of daily activities of the patient. After the failure of the nonsurgical treatment or the appearance of the motor deficit, is established the open or endoscopic surgical treatment with the release of the median nerve. Postoperative recovery in both diseases is crucial to the functionality of the affected upper limb and to the quality of the patient’s life. The patient, a 61 years old man, admitted to the clinic for the functional impotence of the right hand, for the permanent flexion contracture of the metacarpophalangeal joint (MCP) and proximal interphalangeal joint (PIP) of the 4th finger with extension deficit, for the damage of the thumb pulp clamp of the 4th finger, for nocturnal paresthesia of fingers I-III and pain that radiates into the fingertips. After clinical, paraclinical, imagistic and electrical investigations, surgery is practiced partial aponevrectomy, carpal ligament section, external neurolysis of the median nerve, flexor tendon tenolisys. The particularity of this case is the coexistence of two pathologies: Dupuytren’s disease and carpal tunnel syndrome, the decision to solve in the same operator time and the problem of immobilization. Reportation of this case supports previous reports in literature, such as Dupuytren’s disease and carpal tunnel syndrome are observed at the same patient, at the same time or one after another.


1985 ◽  
Vol 10 (1) ◽  
pp. 103-106 ◽  
Author(s):  
H. D. STEWART ◽  
A. R. INNES ◽  
F. D. BURKE

Two hundred and thirty-five patients with displaced Colles' fractures were followed to union, and 209 patients to six months, specifically searching for hand pathology. The incidence of carpal tunnel syndrome was seventeen per cent at three months and twelve per cent at six months. The patients with the syndrome were significantly older and their fractures showed significantly greater residual dorsal angulation. Sixteen patients developed Dupuytren's disease between three and six months, when the incidence was eleven per cent. These patients were significantly older and had average fractures and anatomical results. All cases were mild, with only two contractures. Twenty-one patients were reviewed at a mean of 20.7 months post-fracture, when no case had significantly progressed.


2017 ◽  
Vol 13 (3) ◽  
pp. 243 ◽  
Author(s):  
Yoo Hwan Kim ◽  
Kyung-Sook Yang ◽  
Hanjun Kim ◽  
Hung Youl Seok ◽  
Jung Hun Lee ◽  
...  

2021 ◽  
Author(s):  
Benjamin Patel ◽  
Sam O. Kleeman ◽  
Drew Neavin ◽  
Joseph Powell ◽  
Georgios Baskozos ◽  
...  

AbstractTrigger finger (TF) and carpal tunnel syndrome (CTS) are two common non-traumatic hand disorders that frequently co-occur. By identifying TF and CTS cases in UK Biobank (UKB), we confirmed a highly significant phenotypic association between the diseases. To investigate the genetic basis for this association we performed a genome-wide association study (GWAS) including 2,908 TF cases and 436,579 European controls in UKB, identifying five independent loci. Colocalization with CTS summary statistics identified a co-localized locus at DIRC3 (lncRNA), which was replicated in FinnGen and fine-mapped to rs62175241. Single-cell and bulk eQTL analysis in fibroblasts from healthy donors (n=79) and tenosynovium samples from CTS patients (n=77) showed that the disease-protective rs62175241 allele was associated with increased DIRC3 and IGFBP5 expression. IGFBP5 is a secreted antagonist of IGF-1 signaling, and elevated IGF-1 levels were associated with CTS and TF in UKB, thereby implicating IGF-1 as a driver of both diseases.


2019 ◽  
Vol 38 (10) ◽  
pp. 2933-2940
Author(s):  
Shereen Refaat Kamel ◽  
Hanaa A. Sadek ◽  
Ahmed Hamed ◽  
Omima A. Sayed ◽  
Mona H. Mahmud ◽  
...  

2020 ◽  
Vol 45 (5) ◽  
pp. 455.e1-455.e8 ◽  
Author(s):  
Mark J.W. van der Oest ◽  
Ralph Poelstra ◽  
Reinier Feitz ◽  
Ana-Maria Vranceanu ◽  
Harm P. Slijper ◽  
...  

2008 ◽  
Vol 34 (1) ◽  
pp. 58-59 ◽  
Author(s):  
P. KUMAR ◽  
I. CHAKRABARTI

Carpal tunnel syndrome (CTS) and trigger finger are known to occur together in association with conditions such as diabetes mellitus, rheumatoid arthritis and hypothyroidism. Although most cases that present to a hand clinic have no obvious predisposing cause, the two conditions often appear together in the same patient. We performed a prospective study of the prevalence of CTS in hospital outpatients presenting with trigger finger. Six hundred and eighty-one patients with CTS, trigger finger or both conditions were recruited prospectively. Diagnosis of both disorders was made on clinical grounds. The study group comprised 551 patients with no obvious predisposing cause. Of 211 patients with trigger finger, 91 (43%) also had CTS. This prevalence is substantially higher than the population prevalence of CTS of approximately 4%. Our data support an association between idiopathic CTS and idiopathic trigger finger and lend support to common pathophysiological factors.


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