Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice

2003 ◽  
Vol 143 (1) ◽  
pp. 9-16 ◽  
Author(s):  
F Meotti
Keyword(s):  
Diphenyl Diselenide ◽  
Hepatic Toxicity ◽  
Diphenyl Ditelluride ◽  
Rats And Mice

scholarly journals Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

2014 ◽  
Author(s):  
Joao B Rocha ◽  
Daiane F. Meinerz ◽  
Josiane Allebrandt ◽  
Emily Pansera Waczuk ◽  
Felix Soares ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Index ◽  
Subcutaneous Administration ◽  
Diphenyl Diselenide ◽  
Organoselenium Compounds ◽  
Mutagenic Potential ◽  
Toxicological Effects ◽  
Diphenyl Ditelluride ◽  
High Doses

Organoselenium compounds have been pointed out as therapeutic agents. In contrast, the potential therapeutic aspects of tellurides have not yet been demonstrated. The present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 in mice after in vivo administration. Genotoxicity (as determined by comet assay) and mutagenicicity were used as end-points of toxicity. Subcutaneous administration of high doses of (PhSe)2 or (PhTe)2 (500 μmol/Kg) caused distinct genotoxicity in mice. (PhSe)2 significantly decreased the DNA damage index after 48 and 96 hours of its injection (p<0.05). In contrast, (PhTe) caused a significant increase in DNA damage (p<0.05) after 48 and 96 hours of intoxication. (PhSe)2 did not cause mutagenicity but (PhTe)2 increased the micronuclei frequency, indicating its mutagenic potential. The present study demonstrated that acute in vivo exposure to ditelluride caused genotoxicity in mice, which may be associated with pro-oxidant effects of diphenyl ditelluride. These results indicated that exposure to ditelluride can be genotoxic to mice and the use of this compound and possibly other related tellurides must be carefully controlled.

Diphenyl diselenide and diphenyl ditelluride: neurotoxic effect in brain of young rats, in vitro

2010 ◽  
Vol 340 (1-2) ◽  
pp. 179-185 ◽  
Author(s):  
Ana Cristina Guerra Souza ◽  
Eluza Curte Stangherlin ◽  
Ana Paula Ardais ◽  
Cristina Wayne Nogueira
Keyword(s):  
Diphenyl Diselenide ◽  
Neurotoxic Effect ◽  
Young Rats ◽  
Diphenyl Ditelluride

Fe(II) and sodium nitroprusside induce oxidative stress: a comparative study of diphenyl diselenide and diphenyl ditelluride with their napthyl analog

2011 ◽  
Vol 35 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Mohammad Ibrahim ◽  
Waseem Hassan ◽  
Javed Anwar ◽  
Cristina W. Nogueira ◽  
Joao Batista Teixeira Rocha
Keyword(s):  
Oxidative Stress ◽  
Comparative Study ◽  
Sodium Nitroprusside ◽  
Diphenyl Diselenide ◽  
Diphenyl Ditelluride
Sign in / Sign up

Export Citation Format

Share Document