Key elements of neurotransmitter pathways as biomarkers of effect of neuroactive compounds with different primary mode of action

2021 ◽  
Vol 350 ◽  
pp. S77
Author(s):  
D. Tenji ◽  
I. Vulin ◽  
M. Palangetić ◽  
T. Tomić ◽  
I. Teodorović ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Primary Mode ◽  
Neuroactive Compounds ◽  
Biomarkers Of Effect

Insight into the primary mode of action of TiO2 nanoparticles on Escherichia coli in the dark

PROTEOMICS ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 98-113 ◽  
Author(s):  
Bénédicte Sohm ◽  
Françoise Immel ◽  
Pascale Bauda ◽  
Christophe Pagnout
Keyword(s):  
Escherichia Coli ◽  
Tio2 Nanoparticles ◽  
Mode Of Action ◽  
Primary Mode ◽  
Insight Into

scholarly journals Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by sepantronium bromide (YM155)

2021 ◽  
Author(s):  
Tasaduq Hussain Wani ◽  
Goutam Chowdhury ◽  
Anindita Chakrabarty
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Mode Of Action ◽  
Reactive Oxygen ◽  
Cancer Drug ◽  
Oxygen Species ◽  
Secondary Effects ◽  
Primary Mode ◽  
Anti Cancer ◽  
Sepantronium Bromide

The anti-cancer drug YM155's primary mode of action is generation of reactive oxygen species, while survivin suppression and DNA damage are secondary effects.

The primary mode of action of acifluorfen-Na in intact seedlings is not via tetrapyrrole accumulation during the first dark period following treatment

1990 ◽  
Vol 36 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Joseph M. Mayasich ◽  
Ujjanagouda B. Nandihalli ◽  
Rex A. Liebl ◽  
Constantin A. Rebetz
Keyword(s):  
Mode Of Action ◽  
Dark Period ◽  
Primary Mode

Bas 9052 Effects on Leaf Photosynthesis and Growth

Weed Science ◽  
1983 ◽  
Vol 31 (4) ◽  
pp. 457-461 ◽  
Author(s):  
David R. Gealy ◽  
Fred W. Slife
Keyword(s):  
Zea Mays ◽  
Glycine Max ◽  
Mode Of Action ◽  
Leaf Growth ◽  
Leaf Photosynthesis ◽  
Primary Mode

BAS 9052 {2-[1-(ethoxyimino)-butyl]-5-[2-(ethylthio)-propyl]-3-hydroxy-2-cyclohexene-1-one} and difenopenten {4-[4-[4-(trifluoromethyl)phenoxy]phenoxy]-2-pentenoic acid} concentrations less than 1% (w/w) did not normally inhibit apparent photosynthesis (AP) of corn (Zea maysL. ‘Mo 17 × B73′) leaves for at least 24 h. However, leaf growth was completely inhibited by BAS 9052 within 24 h. Leaf AP was initially more inhibited in soybean (Glycine maxL. ‘Corsoy’) than in corn by each herbicide, but within 48 h soybean AP was usually recovering and plants grew normally. Because inhibition of corn leaf growth preceded that of AP, leaf photosynthesis could not be a primary mode of action for BAS 9052.

scholarly journals Disruption of the Metabolism, Motility and Morphology of Spermatozoa by Injection of a-Chlorohydrin Into Rams

1976 ◽  
Vol 29 (6) ◽  
pp. 545 ◽  
Author(s):  
PDC Brown-Woodman ◽  
IG White
Keyword(s):  
Amino Acid ◽  
Acid Concentration ◽  
Seminal Plasma ◽  
Mode Of Action ◽  
Amino Acid Concentration ◽  
Primary Mode ◽  
Intramuscular Injections ◽  
Glycolytic Activity

Ejaculated spermatozoa from rams given intramuscular injections of <x-chlorohydrin (25 mg/kg, daily for 5 days) were studied. Respiratory and glycolytic activity of the spermatozoa was almost entirely suppressed within 1 day and motility had decreased within 4 days of the first injection. Morphologically abnormal spermatozoa appeared in ejaculates after 2 weeks. The most common abnormality was an increase in the number of spermatozoa with looped or bent tails. There was little change in the fructose or amino acid concentration of the seminal plasma. All effects of <x-chlorohydrin were fully reversible. It is suggested that the initial primary mode of action of <x-chlorohydrin is to disrupt the metabolism of spermatozoa in the cauda epididymis.

scholarly journals Primary Mode of Action of <i>Cistus ladaniferus</i> L. Essential Oil Active Fractions on <i>Staphylococcus aureus</i> Strain

2015 ◽  
Vol 05 (13) ◽  
pp. 881-890 ◽  
Author(s):  
Elodie Guinoiseau ◽  
Anne Luciani ◽  
Dominique de Rocca Serra ◽  
Yann Quilichini ◽  
Liliane Berti ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Essential Oil ◽  
Mode Of Action ◽  
Primary Mode

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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