Leveraging the Power of High Content Screening Using Iterative Data Mining for Ethnically-diverse, Predictive, Animal-free Hepatotoxicity Platform.

2021 ◽  
Vol 350 ◽  
pp. S163
Author(s):  
V.S. Wong ◽  
A Shafi ◽  
K. Cameron ◽  
D.A. Egan
2020 ◽  
Author(s):  
Mohammed J. Zaki ◽  
Wagner Meira, Jr
Keyword(s):  

2010 ◽  
Vol 24 (2) ◽  
pp. 112-119 ◽  
Author(s):  
F. Riganello ◽  
A. Candelieri ◽  
M. Quintieri ◽  
G. Dolce

The purpose of the study was to identify significant changes in heart rate variability (an emerging descriptor of emotional conditions; HRV) concomitant to complex auditory stimuli with emotional value (music). In healthy controls, traumatic brain injured (TBI) patients, and subjects in the vegetative state (VS) the heart beat was continuously recorded while the subjects were passively listening to each of four music samples of different authorship. The heart rate (parametric and nonparametric) frequency spectra were computed and the spectra descriptors were processed by data-mining procedures. Data-mining sorted the nu_lf (normalized parameter unit of the spectrum low frequency range) as the significant descriptor by which the healthy controls, TBI patients, and VS subjects’ HRV responses to music could be clustered in classes matching those defined by the controls and TBI patients’ subjective reports. These findings promote the potential for HRV to reflect complex emotional stimuli and suggest that residual emotional reactions continue to occur in VS. HRV descriptors and data-mining appear applicable in brain function research in the absence of consciousness.


2012 ◽  
Vol 17 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Viren Swami ◽  
Angela Nogueira Campana ◽  
Rebecca Coles

Although patients of cosmetic surgery are increasingly ethnically diverse, previous studies have not examined ethnic differences in attitudinal dispositions toward cosmetic surgery. In the present study, 751 British female university students from three ethnic groups (Caucasians, South Asians, and African Caribbeans) completed measures of acceptance of cosmetic surgery, body appreciation, self-esteem, and demographic variables. Initial between-group analyses showed that Caucasians had lower body appreciation and self-esteem than Asian and African Caribbean participants. Importantly, Caucasians had higher acceptance of cosmetic surgery than their ethnic minority counterparts, even after controlling for body appreciation, self-esteem, age, and body mass index. Further analyses showed that ethnicity accounted for a small proportion of the variance in acceptance of cosmetic surgery, with body appreciation and self-esteem emerging as stronger predictors. Possible reasons for ethnic differences in acceptance of cosmetic surgery are discussed in Conclusion.


2020 ◽  
Vol 14 (4) ◽  
pp. 415-432 ◽  
Author(s):  
Adam Winsler ◽  
Taylor V. Gara ◽  
Alenamie Alegrado ◽  
Sonia Castro ◽  
Tanya Tavassolie

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