Relationship between serum sex hormones and coronary artery disease in postmenopausal women

Maturitas ◽  
1997 ◽  
Vol 28 (1) ◽  
pp. 89-90
Author(s):  
G.B. Phillips ◽  
B.H. Pinkernell ◽  
T.-Y. Jing
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Artery Disease

scholarly journals Association between Endogenous Sex Hormones and Coronary Artery Disease in Postmenopausal Women

2021 ◽  
Author(s):  
Roopali Khanna ◽  
Avinash Bansal ◽  
Sudeep Kumar ◽  
Naveen Garg ◽  
Satyendra Tewari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Vessel Disease ◽  
Triple Vessel Disease ◽  
Traditional Risk Factors ◽  
Artery Disease

Background Incidence of coronary artery disease (CAD) increases significantly in postmenopausal women, which is assumed to be an imbalance between serum androgen and estrogen levels. However, studies assessing serum sex hormones and CAD are few and have shown conflicting results. Objective To compare serum sex hormone levels and traditional risk factors among postmenopausal women with angiographically proven CAD and without CAD. Method The study included consecutive postmenopausal women undergoing coronary angiography in our institute from May 2016 to June 2017. The clinical and coronary angiographic data and traditional risk factors were assessed. Fasting serum levels of estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), and insulin were measured. Results A total of 121 postmenopausal women were included in the study; 69 were CAD and 52 without CAD. Single-vessel disease was most common (55.1%), followed by double-vessel disease (24.6%) and triple-vessel disease (20.3%). Women with CAD had significantly lower estradiol/testosterone (E2/T) ratio (3.7 ± 2.6 vs. 5.4 ± 4.2, p = 0.008) compared with non-CAD group. SHBG, DHEA-S, and insulin levels were similar in CAD and non-CAD groups. The serum level of estradiol predicted the E2/T ratio (r = 0.316, p < 0.001) and positively associated with DHEA (r = 0.181, p = 0.047). Testosterone was negatively associated with E2/T ratio (r = – 0.682, p < 0.001). There was no significant correlation of estrogen, testosterone, or E2/T ratio to lipid profile (total cholesterol, HDL, LDL) in women with CAD. Conclusion E2/T ratio was significantly lowered in postmenopausal women with CAD. E2/T ratio may be a used a predictor of CAD in postmenopausal women

Short-term Anti-Ischemic Effect of 17β-Estradiol in Postmenopausal Women With Coronary Artery Disease

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 2837-2841 ◽  
Author(s):  
Giuseppe M.C. Rosano ◽  
Adriano Mendes Caixeta ◽  
Sergio Chierchia ◽  
Siguemituzo Arie ◽  
Miguel Lopez-Hidalgo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Short Term ◽  
17Β Estradiol ◽  
Artery Disease

Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor α polymorphism

2009 ◽  
Vol 130 (3) ◽  
pp. 355-364 ◽  
Author(s):  
Jolanta Myśliwska ◽  
Aleksandra Rutkowska ◽  
Łukasz Hak ◽  
Janusz Siebert ◽  
Krzysztof Szyndler ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Estrogen Receptor ◽  
Coronary Artery ◽  
Inflammatory Response ◽  
Postmenopausal Women ◽  
Estrogen Receptor Α ◽  
Artery Disease

scholarly journals Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease

2015 ◽  
Vol 19 (2) ◽  
pp. 326-331 ◽  
Author(s):  
Nicola M McKeown ◽  
Adela Hruby ◽  
Rikard Landberg ◽  
David M Herrington ◽  
Alice H Lichtenstein
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Postmenopausal Women ◽  
Vessel Diameter ◽  
Whole Grains ◽  
Plasma Samples ◽  
Whole Grain ◽  
Coronary Artery Atherosclerosis ◽  
Artery Disease ◽  
Change In Mean

AbstractObjectiveThe objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.DesignPlasma AR concentrations were measured by a validated GC–MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.SettingA prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.SubjectsFor the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.ResultsMean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre.ConclusionsPlasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.

scholarly journals Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1139
Author(s):  
Ewelina Anna Dziedzic ◽  
Wiktor Smyk ◽  
Izabela Sowińska ◽  
Marek Dąbrowski ◽  
Piotr Jankowski
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Level ◽  
Postmenopausal Women ◽  
Coronary Atherosclerosis ◽  
History Of ◽  
Artery Disease ◽  
The Impact

Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.

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