Design of a controlled release osmotic pump system of ibuprofen

Preparation andin vitroandin vivoevaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasing API solubility and without resulting in the API degradation. It is found that the VIN release rate was increasing with the citric acid amount at a constant range. Cellulose acetate 398-3 was employed as semipermeable membrane containing polyethylene glycol 6000 and diethyl-o-phthalate as pore-forming agent and plasticizer for controlling membrane permeability. In addition, a clear difference between the pharmacokinetic patterns of VIN immediate release and VIN elementary osmotic pump formulations was revealed. The area under the plasma concentration-time curve after oral administration of elementary osmotic pump formulations was equivalent to VIN immediate release formulation. Furthermore, significant differences found for mean residence time, elimination half-life, and elimination rate constant values corroborated prolonged release of VIN from elementary osmotic pump formulations. These results suggest that the VIN osmotic pump controlled release tablets have marked controlled release characters and the VIN osmotic pump controlled release tablets and the normal tablets were bioequivalent.

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Design of a timed and controlled release osmotic pump system of atenolol

Drug Development and Industrial Pharmacy ◽

10.3109/03639045.2014.913612 ◽

2014 ◽

Vol 41 (6) ◽

pp. 906-915 ◽

Cited By ~ 6

Author(s):

Yingna Xue ◽

Shihui Yu ◽

Hanbing Wang ◽

Jingge Liang ◽

Junjie Peng ◽

...

Keyword(s):

Controlled Release ◽

Osmotic Pump ◽

Pump System

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Design and evaluation of a novel floating osmotic pump system

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/j33k5n ◽

2009 ◽

Vol 12 (1) ◽

pp. 129 ◽

Cited By ~ 3

Author(s):

Zhihong Zhang ◽

Bo Peng ◽

Xinggang Yang ◽

Chao Wang ◽

Guangmei Sun ◽

...

Keyword(s):

Drug Release ◽

Oral Administration ◽

In Vitro Release ◽

Osmotic Pump ◽

Matrix Tablets ◽

In Vivo Evaluation ◽

Pump System ◽

Conventional Tablet

PURPOSE. Find a novel delivery system for oral administration of drugs that have absorption window in the upper part of gastrointestinal (GI) track. METHODS. Dipyridamole was chosen as the model drug. A novel system, which combined the osmotic pump controlled release system and the floating system, was designed; matrix tablets (MT) were prepared for compares. The effects of pH, temperature and hydrodynamic conditions on drug release and the floating behavior of floating osmotic pump system (FOP) were investigated. In vivo evaluation was performed by a three-crossover study in six Beagle dogs relative to the conventional tablet (CT). Cumulative percent input in vivo was compared with that of in vitro release profiles. RESULTS. Floating behavior of FOP, drug releases from FOP and MT were sensitive to pH of dissolution media but not sensitive to temperature; the release of dipyridamole from MT was influenced by stirring rate while drug release from FOP was not. AUC of FOP was larger than MT and CT. The linear correlations between fraction absorbed in vivo and fraction dissolved in vitro was established for FOP-a true zero-order release formula, whereas only a nonlinear correlation was obtained for MT. CONCLUTIONS. FOP could be a novel way for the oral administration for drugs like dipyridamole.

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