Quantitative relationship of carboplatin dose to magnitude of inner and outer hair cell loss and the reduction in distortion product otoacoustic emission amplitude in chinchillas

1997 ◽  
Vol 112 (1-2) ◽  
pp. 199-215 ◽  
Author(s):  
Philip Hofstetter ◽  
Dalian Ding ◽  
Nicholas Powers ◽  
Richard J. Salvi
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Quantitative Relationship ◽  
Otoacoustic Emission ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Relationship Of ◽  
Carboplatin Dose

Protective effect of melatonin against gentamicin ototoxicity

2008 ◽  
Vol 123 (6) ◽  
pp. 598-602 ◽  
Author(s):  
L-F Ye ◽  
Z-Z Tao ◽  
Q-Q Hua ◽  
B-K Xiao ◽  
X-H Zhou ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Body Weight ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Emission Testing ◽  
Gentamicin Ototoxicity

AbstractObjective:To research the protective effect of melatonin against gentamicin ototoxicity.Methods:Guinea pigs were randomly divided into four groups. The first group received intramuscular gentamicin (120 mg/kg body weight/day) for 17 days. Over the same time period, a second group simultaneously received intramuscular gentamicin (120 mg/kg body weight/day) plus (on the other side) intramuscular melatonin (0.3 ml kg body weight/day). Two groups of controls were treated for 17 days with either intramuscular melatonin or intramuscular saline. After the 17 days, each animal underwent distortion product otoacoustic emission testing (both ears). The guinea pigs were sacrificed by decapitation just after the final injection. Their cochleae were used to produce a tissue section, surface preparation and scanning electron microscope preparation.Results:Distortion product otoacoustic emission testing indicated gentamicin-induced hearing loss at 3, 4, 6 and 8 kHz in gentamicin-treated animals. Animals receiving melatonin co-therapy had significantly attenuated hearing loss and their cochleae showed lower rates of outer hair cell loss (comparing the same cochlear turns), compared with gentamicin-treated animals (p < 0.01).Conclusion:These findings confirm the occurrence of outer hair cell loss after gentamicin treatment, and the attenuation of such loss following simultaneous melatonin injection, using the method of morphological evaluation. These results suggest that melatonin protects against gentamicin ototoxicity by interfering with cytotoxic mechanisms.

scholarly journals Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145428 ◽  
Author(s):  
Mary Ann Cheatham ◽  
Roxanne M. Edge ◽  
Kazuaki Homma ◽  
Emily L. Leserman ◽  
Peter Dallos ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Survival ◽  
Outer Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

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