Estimation of the degree of inner and outer hair cell dysfunction from distortion product otoacoustic emission input/output functions

2009 ◽  
Vol 7 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Enrique A. Lopez-Poveda ◽  
Peter T. Johannesen ◽  
Miguel A. Merchán
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Cell Dysfunction ◽  
Distortion Product

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

2015 ◽  
Vol 129 (12) ◽  
pp. 1174-1181 ◽  
Author(s):  
N Wooles ◽  
M Mulheran ◽  
P Bray ◽  
M Brewster ◽  
A R Banerjee
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

scholarly journals Correlation between schroeder-phase effect and distortion product otoacoustic emission findings

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Nur Baizura Salahuddin ◽  
Sarah Rahmat
Keyword(s):  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
Output Function ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Phase Effect ◽  
Cochlear Function ◽  
Distortion Product ◽  
Effect Mechanism

Introduction: Schroeder-phase masking has been proven to be more sensitive than pure tone audiometry in detecting changes in cochlear function. Schroeder harmonic complexes with different phases have been observed to excite basilar membranes differently and give different masking abilities (‘phase effect’) when used as maskers. Previous theory suggested that phase effect was contributed by cochlear non-linearity of outer hair cells (OHC); however the theory was derived from behavioral observation alone. Therefore, this study aims to further investigate the cochlear non-linearity involvement in phase effect mechanism by measuring the Schroeder phase effect together with another electrophysiological test that measures the cochlear non-linearity function, i.e. Distortion Product Otoacoustic Emission (DPOAE). Methods: Twelve normal hearing and four sensorineural hearing loss subjects were recruited. Schroeder phase masking test was conducted and phase effect (using 75 dB A masker) at 1kHz and 2 kHz was measured. DPOAE was recorded at multiple intensities (45-75 dB SPL) for 1 kHz and 2 kHz, and slope of DPOAE input output function was measured. Correlation analysis was performed to find correlation between phase effect and slope of DPOAE input output function. Results: Result showed no significant correlation (p > 0.05) between phase effect and slope of DPOAE input output function. Conclusions: This findings suggest that Schroeder-phase effect may not be/ may not only be contributed by OHC’s cochlear non-linearity. This finding opens the possibility of other auditory functions’ involvement in phase effect mechanism, and contribute to better understanding towards auditory perceptions.

Sensitivity of Distortion Product Otoacoustic Emissions in Noise-Exposed Chinchillas

2005 ◽  
Vol 16 (02) ◽  
pp. 069-078 ◽  
Author(s):  
Bob Davis ◽  
Wei Qiu ◽  
Roger P. Hamernik
Keyword(s):  
Otoacoustic Emissions ◽  
Evoked Potential ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Speech Discrimination ◽  
Distortion Product Otoacoustic Emission ◽  
Hearing Conservation ◽  
Distortion Product ◽  
Cochlear Pathology ◽  
Sensorineural Hearing Impairment

The present study investigates the effect of small amounts of outer hair cell (OHC) loss on distortion product otoacoustic emission (DPOAE) levels and evoked potential permanent threshold shifts (PTS) in a population of 12 noise-exposed chinchillas. The group mean DPOAE level, which decreased by up to ~15 dB in the presence of less than 8 dB PTS and 15% OHC loss, indicates that DPOAEs can detect an underlying cochlear pathology (i.e., OHC damage/loss) despite the presence of normal to near normal thresholds. The sensitivity of DPOAEs in detecting OHC loss makes this test measure suited for diagnosing sensorineural hearing impairment, particularly when abnormal auditory symptoms (i.e., speech discrimination problems) are associated with a normal audiogram in the clinical setting and as part of a hearing conservation program.

Protective effect of melatonin against gentamicin ototoxicity

2008 ◽  
Vol 123 (6) ◽  
pp. 598-602 ◽  
Author(s):  
L-F Ye ◽  
Z-Z Tao ◽  
Q-Q Hua ◽  
B-K Xiao ◽  
X-H Zhou ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Body Weight ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Emission Testing ◽  
Gentamicin Ototoxicity

AbstractObjective:To research the protective effect of melatonin against gentamicin ototoxicity.Methods:Guinea pigs were randomly divided into four groups. The first group received intramuscular gentamicin (120 mg/kg body weight/day) for 17 days. Over the same time period, a second group simultaneously received intramuscular gentamicin (120 mg/kg body weight/day) plus (on the other side) intramuscular melatonin (0.3 ml kg body weight/day). Two groups of controls were treated for 17 days with either intramuscular melatonin or intramuscular saline. After the 17 days, each animal underwent distortion product otoacoustic emission testing (both ears). The guinea pigs were sacrificed by decapitation just after the final injection. Their cochleae were used to produce a tissue section, surface preparation and scanning electron microscope preparation.Results:Distortion product otoacoustic emission testing indicated gentamicin-induced hearing loss at 3, 4, 6 and 8 kHz in gentamicin-treated animals. Animals receiving melatonin co-therapy had significantly attenuated hearing loss and their cochleae showed lower rates of outer hair cell loss (comparing the same cochlear turns), compared with gentamicin-treated animals (p < 0.01).Conclusion:These findings confirm the occurrence of outer hair cell loss after gentamicin treatment, and the attenuation of such loss following simultaneous melatonin injection, using the method of morphological evaluation. These results suggest that melatonin protects against gentamicin ototoxicity by interfering with cytotoxic mechanisms.

scholarly journals Relation of distortion-product otoacoustic emission input-output functions to loudness

2013 ◽  
Vol 134 (1) ◽  
pp. 369-383 ◽  
Author(s):  
Daniel M. Rasetshwane ◽  
Stephen T. Neely ◽  
Judy G. Kopun ◽  
Michael P. Gorga
Keyword(s):  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Distortion Product
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