Prevention of retrocochlear hearing loss in murine experimental allergic encephalitis with T cell receptor Vβ8-specific antibody

2003 ◽  
Vol 1240 ◽  
pp. 1169-1173
Author(s):  
M Suzuki ◽  
K.C Cheng ◽  
M.S Krug ◽  
H Kohzaki ◽  
Y Yazawa ◽  
...  
Keyword(s):  
Hearing Loss ◽  
T Cell ◽  
T Cell Receptor ◽  
Specific Antibody ◽  
Cell Receptor ◽  
Experimental Allergic Encephalitis ◽  
Experimental Allergic

T cell receptors in autoimmune disease as targets for immune intervention

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 656-661 ◽  
Author(s):  
Hans Acha-Orbea ◽  
L. Steinman ◽  
H. O. McDevitt
Keyword(s):  
T Cell ◽  
Autoimmune Disease ◽  
T Cell Receptor ◽  
Experimental Allergic Encephalomyelitis ◽  
Antibody Therapy ◽  
Cell Receptor ◽  
Allergic Encephalomyelitis ◽  
Immune Intervention ◽  
Receptor Antibodies ◽  
Experimental Allergic

The optimal form of treatment for an autoimmune disease should be highly specific, have few side effects, and allow treatment of clinically apparent disease. One target that could fulfill these requirements is the T cell receptor. To answer the question whether treatment of autoimmune disesase is possible with anti-T cell receptor antibodies, the heterogeneity of T cell receptor elements utilized in the T cell mediated autoimmune disease experimental allergic encephalomyelitis was analyzed. The limited heterogeneity of these elements allowed prevention and treatment of clinical autoimmune disease with anti-T cell receptor monoclonal antibodies. These results and their potential value for other autoimmune diseases are discussed.Key words: T cell receptor, autoimmune disease, monoclonal antibody therapy, experimental allergic encephalomyelitis.

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 ◽  
Vol 24 (4) ◽  
pp. 940-946 ◽  
Author(s):  
Alessandra Franco ◽  
Scott Southwood ◽  
Thomas Arrhenius ◽  
Vijay K. Kuchroo ◽  
Howard M. Grey ◽  
...  
Keyword(s):  
T Cell ◽  
Receptor Antagonist ◽  
T Cell Receptor ◽  
Experimental Allergic Encephalomyelitis ◽  
Cell Receptor ◽  
Allergic Encephalomyelitis ◽  
Antagonist Peptides ◽  
Highly Effective ◽  
Experimental Allergic
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