Medical management for the prevention of kidney stones

The alarming fact is that approximately one out of every 10 of us will have a kidney stone during our lifetime. The increasing prevalence and associated costs of kidney stones have resulted in it being one of the most commonly encountered and impactful medical conditions. Contributing factors include, but are not limited to, diet, climate, genetics, medications, activity and underlying medical conditions. Symptoms generally parallel stone size. Treatment varies from supportive to procedural (invasive and non-invasive). Prevention remains the best way to avoid this condition especially given the high recurrence rate. First time stone formers require counselling regarding dietary adjustments. Certain risk factors ultimately require a more in-depth metabolic investigation, especially if stones are recurrent. Ultimately, management is defined by stone composition. Where appropriate, we review both pharmacologic and non-pharmacologic options. Pivotal to successful prevention is patient education and the encouragement of compliance with the appropriate regimen.

Measuring Resilience in Women with Endometriosis

Endometriosis is a multifactorial disease with pathophysiological factors not yet well known; it also presents a wide symptomatic range that makes us think about the need for multidisciplinary management. It is a chronic disease in which there is no definitive treatment, and is associated in a large majority of cases with psychological pathology. Connecting comorbidities and multimorbidities on a neurobiological, neuropsychological, and pathophysiological level could significantly contribute to their more successful prevention and treatment. In our study, resilience is analyzed as an adjunctive measure in the management of endometriosis. Methods: A multi-centre, cross-sectional study was performed to analyse resilience levels in a sample of Spanish women suffering from endometriosis. CDRIS-25, CDRIS-10, BDI, the STAI, and the SF-36 Health Questionnaire were used for assessments. A representative group of 202 women with endometriosis was recruited by consecutive sampling. Exploratory and confirmatory factor analyses were performed for both resilience scales. Results: Mean CDRIS-25 and CDRIS-10 scores were 69.58 (SD 15.1) and 29.37 (SD 7.2), respectively. Women with adenomyosis and without signs of deep endometriosis showed the lowest scores. The best predictive model included women’s age, years of endometriosis evolution, number of pregnancies, and history of fertility problems as the best predictive factors. Conclusions: Women build resilience as the number of years of evolution of the disease increases. Symptoms such as dyspareunia and continued abdominal pain were more prevalent among less resilient women.

HILIC -MS/MS Analysis of Adenosine in Patient Blood

Adenosine is a purine ribonucleoside with important roles in various physiological processes. A number of studies have indicated the importance of adenosine in cardiovascular diseases including syncope; however, the accurate determination of adenosine in human blood is challenging due to the molecule’s instability. In the present study, we report a simple method for the pre-treatment of blood samples and the development of a fast and efficient hydrophilic interaction chromatographic tandem mass spectrometry method for the analysis of adenosine in patient blood. During collection, samples were mixed directly with a solvent mixture containing 95% acetonitrile and 10 mM ammonium formate in a Vacutainer tube, resulting in successful prevention of adenosine metabolic processes and direct blood sample deproteinization. The method was validated according to bioanalytical industry guidelines and found to be accurate, repeatable, specific and sensitive with LLOQ 0.005 μg/mL, thus allowing its application in the analysis of real clinical samples.

Successful Prevention of Fetal Autoimmune-Mediated Heart Block by Combined Therapies With Hydroxychloroquine and Intravenous Immunoglobulin: A Case Report

A fetal autoimmune-mediated atrioventricular block is a passively acquired autoimmune disease in which maternal autoantibodies enter the fetal circulation via the placenta and subsequently cause inflammation and fibrosis of the atrioventricular node. Once fetal autoimmune-mediated atrioventricular block occurs, it only takes a short time to progress from first-degree atrioventricular block to complete atrioventricular block, meaning that the damage is often irreversible. Autoimmune—associated AVB, a rare but life—threatening disorder, occurs in 2–5% of pregnancies with positive anti—Ro/SSA (the most common one) and La/SSB antibodies. The perinatal mortality of neonates with AVB outlined in research is approximately 30%. Thus far, for autoimmune-associated AVB fetuses, currently used treatments include corticosteroids, hydroxychloroquine, intravenous immunoglobulin (IVIG), b—sympathomimetic agent, and even plasma exchange. Currently, approaches for preventing the progression and recurrence of a fetal atrioventricular block are still controversial. Here, we reported a baby of successful prevention from the fate of the fetal atrioventricular block by adopting prophylactic comprehensive prenatal therapy.

Turning The Tables

This chapter outlines the different ways of combatting viruses. Smallpox was the most lethal of the recurrent childhood infections, and, until the late eighteenth century, had it all its own way. But in 1715, when smallpox virus infected Lady Mary Wortley Montagu, the fightback began. This turn of events gave Lady Mary a keen interest in smallpox that led, a few years later, to the first successful prevention of the disease in Europe. However, inoculation was obviously not entirely safe and was not universally accepted. Despite this, it continued to be popular until 1798, when Edward Jenner published the details of a safer alternative: vaccination. Following smallpox, rabies virus was the next to be prevented by a vaccine, this time produced by microbiologist Louis Pasteur working in Paris in the mid 1800s. From the mid 1950s onwards, a surge in production saw vaccines against common viruses like polio, measles, rubella, and mumps, as well as common bacterial infections like diphtheria, pertussis, and tetanus, being rolled out to all children in western countries. The chapter then looks at how these vaccines were prepared and the recent advances in vaccinology spurred on by the COVID-19 pandemic. It also considers flu vaccines, subunit vaccines, and microbial treatments.

PROBLEM ISSUES OF PREVENTIVE WORK OF PRIMARY CARE INSTITUTIONS

Introduction. The article is devoted to the problematicissues of preventive work of primary care institutions.The purpose of the study: is to analyze the effectivenessof preventive areas of work of primary care physicians.Material and methods. The implementation of thevolume of preventive vaccinations for 2018-2020, theresults of preventive examinations of children has beenstudied. A survey of medical workers and parents of childrenon the effectiveness of preventive work was carried out.Results. Irregular delivery of vaccines (from 35% to78% for all groups of immunological drugs) significantlyaffected the implementation of preventive vaccinations,which decreased compared to previous years. Theuncertainty of the health workers themselves about thesafety of vaccines, which is the case with family doctors(65.33 ± 2.92 %) and their nurses (51.24 ± 2.53 %), remainsproblematic. Examples of successful prevention work arethe increase in the number of children under 6 monthsof age who were exclusively breastfed (74.3 %) and thecommitment of parents to breastfeeding (83.5 - 85.5 %).Conclusions. The problematic issues of preventivework are lack of time, lack of vaccines, low prestige ofpreventive work and lack of material incentives. From30.6% of parents at pediatricians to 41.7% of parentsat family doctors are dissatisfied with the amount ofinformation received from medical workers.

Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh

As the COVID-19 pandemic continues to ravage across the globe and take millions of lives and like many parts of the world, the second wave of the pandemic hit Bangladesh, this study aimed at understanding its causative agent, SARS-CoV-2 at the genomic and proteomic level and provide precious insights about the pathogenesis, evolution, strengths and weaknesses of the virus. As of Mid-June 2021, over 1500 SARS-CoV-2 genomesequences have been deposited in the GISAID database from Bangladesh which were extracted and categorized into two waves. By analyzing these genome sequences, it was discovered that the wave-2 samples had a significantly greater average rate of mutation/sample (30.79%) than the wave-1 samples (12.32%). Wave-2 samples also had a higher frequency of deletion, and transversion events. During the first wave, the GR clade was the most predominant but it was replaced by the GH clade in the latter wave. The B.1.1.25 variant showed the highest frequency in wave-1 while in case of wave-2, the B.1.351.3 variant, was the most common one. A notable presence of the delta variant, which is currently at the center of concern, was also observed. Comparison of the Spike protein found in the reference and the 3 most common lineages found in Bangladesh namely, B.1.1.7, B.1.351, B.1.617 in terms of their ability to form stable complexes with ACE2 receptor revealed that B.1.617 had the potential to be more transmissible than others. Importantly, no indigenous variants have been detected so far which implies that the successful prevention of import of foreign variants can diminish the outbreak in the country.

PENYULUHAN HUKUM TATANAN NORMA BARU DESA DALAM UPAYA PENCEGAHAN DAN PENGENDALIAN PANDEMI COVID-19

The COVID-19 pandemic is being felt by all countries. Prevention and control are the main tasks of the government and must be carried out by the community. Community participation is at the core of successful prevention and control. The stages of service are carried out by synergizing between the campus and the health service agency of Central Bangka Regency. The location of the implementation in Nibung Village is to increase participation and socialize the new village norm order in efforts to prevent and control the Covid19 pandemic. Synergy and the implementation of the tri dharma obligations are carried out for success in passing the pandemic and the village remains maximal in implementing the new normal.