scholarly journals Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances11The PAcing THerapies in Congestive Heart Failure (PATH-CHF) study was supported by a grant from the Guidant Corporation (St. Paul, Minnesota). Drs. Pochet, Salo, Kramer and Spinelli have corporate appointments with Guidant Corp.

2001 ◽  
Vol 38 (7) ◽  
pp. 1957-1965 ◽  
Author(s):  
Christoph Stellbrink ◽  
Ole-Alexander Breithardt ◽  
Andreas Franke ◽  
Stefan Sack ◽  
Patricia Bakker ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Resynchronization Therapy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Failure Path ◽  
Ventricular Conduction

scholarly journals Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach

Cardiology ◽  
2019 ◽  
Vol 142 (2) ◽  
pp. 116-128 ◽  
Author(s):  
Asim Katbeh ◽  
Guy Van Camp ◽  
Emanuele Barbato ◽  
Maurizio Galderisi ◽  
Bruno Trimarco ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Myocardial Dysfunction ◽  
Biventricular Pacing ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Conduction Delay ◽  
Resynchronization Therapy ◽  
Ventricular Conduction

Since the first report on biventricular pacing in 1994, cardiac resynchronization therapy (CRT) has become standard for patients with advanced heart failure (HF) and ventricular conduction delay. CRT improves myocardial function by resynchronizing myocardial contraction, which results in reverse left ventricular remodeling and improves symptoms and clinical outcomes. Despite the accelerated development of CRT device technology and its increased application in treating HF patients, almost one-third of these patients do not respond to the therapy or gain any clinical benefit from device implantation. Over the last decade, multiple cardiac imaging modalities have provided a deeper understanding of myocardial pathophysiology, thereby improving HF treatment management. However, the optimal strategy for improving the CRT response remains debatable. This article provides an updated overview of the electropathophysiology of myocardial dysfunction in ventricular conduction delay and the diagnostic approaches involving the use of multiple modalities.

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