STRONG CORRELATION BETWEEN AORTIC VALVE CALCIFICATION SCORE BY CARDIAC COMPUTED TOMOGRAPHY AND TOTAL VALVE CALCIUM IN PATIENTS WITH SEVERE AORTIC VALVE STENOSIS

AbstractThe objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107 non-smokers with AH (mean age 67.16 ± 8.48 years) were qualified for the study. The degree of exposure to ETS was assessed using the Second-hand Smoke Exposure Scale (SHSES) questionnaire. Study group was divided depending on ETS exposure: A—no exposure, B—low, C—medium and D—high. AVCS was measured based on the aortic valve plane multiplanar reconstruction from the non-contrast phase of the cardiac computed tomography. The Agatston algorithm was used, in which calcifications were considered changes with a density exceeding 130 HU. The mean AVCS value in the study group of patients was 213.59 ± 304.86. The AVCS was significantly lower in subgroup A than in subgroups C and D. In subgroup A, the lack of aortic valve calcification (AVCS = 0) was observed significantly more frequently than in subgroups C and D. There was a positive correlation between the number of SHSES points and the AVCS value (r = 0.37, p < 0.05). Based on the ROC curve, the SHSES value was determined as the optimal cut-off point for the prediction of AVCS = 0, amounting to 3 points. The accuracy of SHSES < 3 as the predictor of AVCS = 0 was set at 62.18%. Hypertensive patients have an unfavourable relationship between the amount of exposure to ETS, determined on the SHSES scale, and the AVCS value.

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QUANTIFYING AORTIC VALVE CALCIFICATION FROM A CONTRAST-ENHANCED CARDIAC COMPUTED-TOMOGRAPHY ANGIOGRAPHY STUDY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(15)61170-6 ◽

2015 ◽

Vol 65 (10) ◽

pp. A1170

Author(s):

Abdulrahman Alqahtani ◽

Kevin Boczar ◽

Vinay Kansal ◽

Girish Dwivedi ◽

Kwan-Leung Chan ◽

...

Keyword(s):

Computed Tomography ◽

Aortic Valve ◽

Computed Tomography Angiography ◽

Cardiac Computed Tomography ◽

Aortic Valve Calcification ◽

Valve Calcification ◽

Cardiac Computed Tomography Angiography ◽

Contrast Enhanced

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Computed Tomography Derived Aortic Valve Calcification Score as a Predictor of Balloon Rupture During Percutaneous Balloon Aortic Valvuloplasty

Heart Lung and Circulation ◽

10.1016/j.hlc.2018.06.911 ◽

2018 ◽

Vol 27 ◽

pp. S445

Author(s):

S. Adusumalli ◽

R. Markham ◽

M. Fletcher ◽

M. Savagae ◽

G. Scalia ◽

...

Keyword(s):

Computed Tomography ◽

Aortic Valve ◽

Aortic Valve Calcification ◽

Balloon Aortic Valvuloplasty ◽

Valve Calcification ◽

Percutaneous Balloon ◽

Calcification Score ◽

Aortic Valvuloplasty

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Sex differences in aortic valve calcification in severe aortic valve stenosis: association between computer tomography assessed calcification and valvular calcium concentrations

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeaa096 ◽

2020 ◽

Author(s):

Louise Linde ◽

Rasmus Carter-Storch ◽

Nicolaj Lyhne Christensen ◽

Kristian Altern Øvrehus ◽

Axel Cosmus Pyndt Diederichsen ◽

...

Keyword(s):

Sex Differences ◽

Aortic Valve ◽

Aortic Valve Stenosis ◽

Calcium Concentration ◽

Severe Aortic Stenosis ◽

Cardiac Computed Tomography ◽

Aortic Valve Area ◽

Aortic Valve Calcification ◽

Valve Calcification ◽

Valve Area

Abstract Aims The aims of this study were to investigate the correlation and sex differences between total valve calcium, valve calcium concentration, and aortic valve calcification (AVC) in explanted valves from patients with severe aortic valve stenosis undergoing aortic valve replacement (AVR). Methods and results Sixty-nine patients with severe aortic stenosis (AS) scheduled for elective AVR underwent echocardiography and cardiac computed tomography (CT) prior to surgery (AVCin vivo) and CT of the explanted aortic valve (AVCex vivo). Explanted valves were prepared in acid solution, sonicated, and analysed with Arsenazo III dye to estimate total valve calcium and valve calcium concentration. Median AVCex vivo was 2082 (1421–2973) AU; mean valve calcium concentration was 1.43 ± 0.42 µmol Ca2+/mg tissue; median total valve calcium 156 (111–255) mg Ca2+, and valve calcium density 52 (35–81) mg/cm2. AVC displayed a strong correlation with total valve calcium (R2 = 0.98, P < 0.001) and a moderate correlation with valve calcium concentration (R2 = 0.62, P < 0.001). Valvular calcium concentration was associated with sex, aortic valve area, and mean gradient. After adjusting for age and estimated glomerular filtration rate, sex and mean gradient remained associated with valve calcium concentrations. Conclusion AVC score provides a strong estimate for total valve calcium but to a lesser degree calcium concentration in the valve tissue of patients with severe AS. Females presented lower valvular calcium concentrations than males irrespective of AS severity, adding evidence and providing support to the important point that sex differences in valvular calcium concentration in AS does not reflect valvular size.

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