scholarly journals Morphologic features of the ductus arteriosus after prostaglandin E1administration for ductus-dependent congenital heart defects

1983 ◽  
Vol 1 (2) ◽  
pp. 471-475 ◽  
Author(s):  
In-Sook Park ◽  
Michael R. Nihill ◽  
Jack L. Titus
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ductus Arteriosus

scholarly journals Congenital Heart Defects Are Rarely Caused by Mutations in Cardiac and Smooth Muscle Actin Genes

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Tatiana Khodyuchenko ◽  
Anna Zlotina ◽  
Tatiana Pervunina ◽  
Dmitry Zverev ◽  
Anna Malashicheva ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Smooth Muscle Actin ◽  
Ductus Arteriosus ◽  
Control Group ◽  
Missense Mutations ◽  
Muscle Actin ◽  
Cardiac Actin

Background. Congenital heart defects (CHDs) often have genetic background due to missense mutations in cardiomyocyte-specific genes. For example, cardiac actin was shown to be involved in pathogenesis of cardiac septum defects and smooth muscle actin in pathogenesis of aortic aneurysm in combination with patent ductus arteriosus (PDA). In the present study, we further searched for mutations in humanα-cardiac actin (ACTC1) and smooth muscleα-actin (ACTA2) genes as a possible cause of atrial septum defect type II (ASDII) and PDA.Findings. Total genomic DNA was extracted from peripheral blood of 86 individuals with ASDs and 100 individuals with PDA. Coding exons and flanking intron regions ofACTC1(NM_005159.4) andACTA2(NM_001613) were amplified by PCR with specific primers designed according to the corresponding gene reference sequences. PCR fragments were directly sequenced and analyzed. Sequence analysis ofACTC1andACTA2did not identify any nucleotide changes that altered the coding sense of the genes. InACTC1gene, we were able to detect one previously described nucleotide polymorphism (rs2307493) resulting in a synonymous substitution. The frequency of this SNP was similar in the study and control group, thus excluding it from the possible disease-associated variants.Conclusions. Our results confirmed that the mutations inACTC1gene are rare (at least <1%) cause of ASDII. Mutations inACTA2gene were not detected in patients with PDA, thus being excluded from the list of frequent PDA-associated genetic defects.

scholarly journals Spectrum of associated congenital heart defects in patients with “Non-Cardiac Congenital defects at a tertiary care children hospital in Pakistan”

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Muhammad Sohail Arshad ◽  
Muhammad Aslam ◽  
Shahnab Ahmad ◽  
Muhammad Kashif
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Vascular Malformations ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Tertiary Care ◽  
Primary Diagnosis ◽  
Congenital Defects

Objectives: To assess the frequency and pattern of associated congenital heart disease (CHD) among patients with “non-cardiac congenital defects”. Methods: An observational study was done at Paediatric Cardiology Department, The Children’s Hospital and The Institute of Child Health, Multan, Pakistan, from December 2018 to November 2019. Children from birth to 15 years having non-cardiac congenital defects, referred for cardiac evaluation from surgical unit during the study period were enrolled. Echocardiography was done to confirm diagnosis of CHD by consultant pediatric cardiologist. Results: Out of a total of 323 cases, 176 (54.5%) were male. Out of 323 patients, 160 (49.5%) belonged to age one month to one year. Vascular malformations were the most frequent primary diagnosis among our cases, seen in 69 (21.4%) children followed by cleft lip and palate 55 (17.2%), cleft palate only 52 (16.1%), Cleft lip only 40 (12.4%) and ARM high variety 33 (10.2%). CHD was found among 42 (13.0%) children while patent ductus arteriosus (PDA) and VSD were the commonest finding seen in 14 (33.3%) and 6 (14.3%) children respectively. Conclusion: Frequency of associated CHD among patients with non-cardiac congenital defects was high (13.0%). Children with cleft lip and/or palate should be given more attention because of the high incidence of CHD in this group. Echocardiography must be advised for the timely identification of any possible type of CHD. doi: https://doi.org/10.12669/pjms.37.3.3604 How to cite this:Arshad MS, Aslam M, Ahmad S, Kashif M. Spectrum of associated congenital heart defects in patients with “Non-Cardiac Congenital defects at a tertiary care children hospital in Pakistan”. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3604 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pharmacotherapy of Congenital Heart Defects

2004 ◽  
Vol 9 (3) ◽  
pp. 160-178
Author(s):  
Shannan Eades
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Pediatric Population ◽  
Ductus Arteriosus ◽  
Pharmacological Agents ◽  
Mild Heart Failure ◽  
Cardiovascular Defects

Congenital cardiovascular defects account for significant morbidity and mortality in the pediatric population. Complications of congenital heart disease are lesion-dependent and may range from mild heart failure with no cyanosis to severe cyanosis and shock. Pharmacotherapy of congenital heart disease is also lesion-dependent and usage may range from palliative agents (e.g., prostaglandin E1 for relaxation of aortic stricture) to corrective agents (e.g., indomethacin for closure of the ductus arteriosus). This review will discuss the aberrant pathophysiology and complications associated with specific congenital heart defects, as well as the selection of pharmacological agents used in the management of these defects.

Survival, Morbidities, and Developmental Outcomes among Low Birth Weight Infants with Congenital Heart Defects

2020 ◽  
Author(s):  
Mihai Puia-Dumitrescu ◽  
Laura N. Sullivan ◽  
David Tanaka ◽  
Kimberley Fisher ◽  
Rick Pittman ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Congenital Heart Defects ◽  
Gestational Age ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Developmental Outcomes ◽  
Low Birth Weight Infants ◽  
Common Diagnosis

Objective Prematurity and low birth weight (LBW) are risk factors for increased morbidity and mortality in infants with congenital heart defects (CHDs). We sought to describe survival, inhospital morbidities, and 2-year neurodevelopmental follow-up in LBW infants with CHD. Study Design We included infants with birth weight (BW) <2,500 g diagnosed with CHD (except isolated patent ductus arteriosus) admitted January 2013 to March 2016 to a single level-IV academic neonatal intensive care unit. We reported CHD prevalence by BW and gestational age; selected in-hospital morbidities and mortality by infant BW, CHD type, and surgical intervention; and developmental outcomes by Bayley's scales of infant and toddler development, third edition (BSID-III) scores at age 2 years. Results Among 420 infants with CHD, 28 (7%) underwent cardiac surgery. Median (25th and 75th percentiles) gestational age was 30 (range: 27–33) weeks and BW was 1,258 (range: 870–1,853) g. There were 134 of 420 (32%) extremely LBW (<1,000 g) infants, 82 of 420 (20%) were small for gestational age, and 51 of 420 (12%) multiples. Most common diagnosis: atrial septal defect (260/420, 62%), followed by congenital anomaly of the pulmonary valve (75/420, 18%). Most common surgical procedure: pulmonary artery banding (5/28, 18%), followed by the tetralogy of Fallot corrective repair (4/28, 14%). Survival to discharge was 88% overall and lower among extremely LBW (<1,000 g, 81%) infants and infants undergoing surgery (79%). Comorbidities were common (35%); retinopathy of prematurity and bronchopulmonary dysplasia were most prevalent. BSID-III scores were available on 148 of 176 (84%); any scores <85 were noted in 73 of 148 (49%), with language being most commonly affected. Conclusion Among LBW infants with congenital heart disease, hospital mortality varied by BW and cardiac diagnosis. Key Points

scholarly journals Feasibility and Safety of Percutaneous Cardiac Interventions for Congenital and Acquired Heart Defects in Infants ≤1000 g

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 826
Author(s):  
Ranjit Philip ◽  
Jeffrey Towbin ◽  
Neil Tailor ◽  
Vijaya Joshi ◽  
Jason N. Johnson ◽  
...  
Keyword(s):  
Adverse Event ◽  
Patent Ductus Arteriosus ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Transcatheter Closure ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Major Adverse Event ◽  
Procedural Success ◽  
Patent Ductus

The transcatheter closure of patent ductus arteriosus (TCPC) has been demonstrated to be feasible even in infants weighing ≤1000 g. However, other percutaneous cardiac interventions (PCI) for such small infants born with congenital heart defects (CHD) or acquired heart defects (AHD) have not been well described. The purpose of this study was to describe the feasibility and safety of PCI in infants ≤1000 g. A retrospective review was conducted between June 2015 and May 2021, looking at 148 consecutive PCIs performed on infants weighing ≤1000 g at the time of the procedure. The procedural success rate was 100%. The major adverse event (AE) rate for TCPC was 3%, while there were no major AEs for other PCI. It is feasible to perform PCIs in infants weighing ≤1000 g with CHD and AHD using currently available technologies.

scholarly journals Congenital heart defects in dogs: A retrospective study of 301 dogs

2017 ◽  
Vol 73 (10) ◽  
pp. 651-656
Author(s):  
Magdalena Garncarz ◽  
Marta Parzeniecka-Jaworska ◽  
Olga Szaluś-Jordanow
Keyword(s):  
Retrospective Study ◽  
Congenital Heart Defects ◽  
Medical Records ◽  
Congenital Heart ◽  
Septal Defect ◽  
Early Recognition ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Subaortic Stenosis ◽  
Patent Ductus

The aim of the study was to assess the frequency of congenital heart defects in a population of dogs in Poland and to determine which breeds were affected by particular defects. A retrospective study of the medical records of cardiologically examined dogs revealed 301 cases of echocardiographically confirmed congenital heart defects. Dogs with congenital heart defects made up 2.7% of the dogs that underwent a cardiologic examination. The age at diagnosis ranged from 2 weeks to 190 months. Mixed breeds (33 dogs, 11%), Bull Terriers (31, 10%), Boxers (28, 9%), German Shepherds (17, 6%), Yorkshire Terriers (17, 6%), and French Bulldogs (16, 5%) were the most frequently affected breeds. Subaortic stenosis (120 cases, 33.9%), pulmonic stenosis (64, 18.1%), patent ductus arteriosus (59, 16.7%), mitral valve dysplasia (56, 15.8%), ventricular septal defect (24, 6.8%) and tricuspid valve dysplasia (17, 4.8%) were the most frequent congenital heart defects recognized in this study. Isolated congenital heart disease occurred in 258 dogs (86%), while multiple heart defects were noted in 43 dogs (14%). Most (60%) congenital heart defects were recognized in dogs older than 1 year. Early recognition of congenital heart defects is important for better patient care. Collecting information on the frequency of congenital heart defects in particular breeds will be useful in educating breeders and thus in improving the overall health of the breed.

scholarly journals Pattern of congenital heart diseases among clinically diagnosed Down’s syndrome children

2015 ◽  
Vol 6 (1) ◽  
pp. 18-20
Author(s):  
Abu Sayed Munsi ◽  
Manzoor Hussain ◽  
Rezoana Rima ◽  
Robi Biswas ◽  
Salahuddin Mahmud ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Atrioventricular Septal Defect ◽  
Female Ratio ◽  
Cardiology Department

Background : Down’s syndrome (DS) is the commonest genetic cause of malformation with congenital heart defects.Objectives : This study was conducted to evaluate the frequency of various congenital heart defects in children with clinically diagnosed Down’s syndrome in Dhaka Shishu Hospital.Material & Methods : This prospective study was conducted at Pediatric cardiology department of Dhaka Shishu Hospital from 1st February 2013 to 31st January 2014. Admitted Seventy four phenotypically Down’s syndrome patients were included in this study. After taking detailed history and physical examination, all these patients were subjected to Color Doppler echocardiography in addition to routine laboratory investigations.Results : Total 74 down’s Syndrome patients were admitted at cardiology department during the study period. Among them 35 (47.29%) were males and 39 (52.71%)were females with male to female ratio of 1:1.12. Atrioventricular septal defect was the commonest defect 15(20.27%), followed by Ventricular septal defect 12(16.21%), Patent ductus arteriosus 11(14.86%), Atrial septal defect 7(9.46%), Tetralogy of Fallots 3(4.05%), Pentology of Fallots 2(2.70%), Dextrocardia with D _ TGA 1(1.35%), Total anomalous pulmonary venous drainage 1(1.35%) but Multiple congenital heart disease were 22(29.72%) cases. Along with congenital heart disease 3(4.05%) patients had GIT abnormality, 4(5.4%) patient had congenital hypothyroidism and 3(4.05%) patients had Eye problem.Conclusion : Congenital heart defects are common in children with Down’s syndrome. The commonest one is Atrioventricular septal defect in our set-up.Northern International Medical College Journal Vol.6(1) 2014: 18-20

scholarly journals Pulmonary hypertension in patients with acyanotic congenital heart defects

2020 ◽  
Vol 1 (2) ◽  
pp. 45
Author(s):  
Vivi Widianto Tjan
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart Defects ◽  
Medical Records ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Congenital Disease ◽  
Female Patients ◽  
Male Patients

Congenital Heart Defects (CHD) is the most common congenital disease that affects 8 out of every 1000 births. CHD can be classified as cyanotic and acyanotic. Acyanotic is the most frequently diagnosed CHD. The most common complication in acyanotic CHD is pulmonary hypertension. This descriptive study was based on medical records of acyanotic CHD patients with pulmonary hypertension in RSUD Abdul Wahab Sjahranie Samarinda from 2015 to 2016 who were diagnosed by a cardiologist and confirmed with echocardiography. There were 62 patients diagnosed with acyanotic CHD and pulmonary hypertension, which 58% of patients were diagnosed with Atrial Septal Defect (ASD), Ventricular Septal Defect (VSD) (21%), and Patent Ductus Arteriosus (PDA) (21%). Defect sizes distribution were mostly large (66%), then medium (29%), and small (5%). There were 56% of patients diagnosed before 18 years old and 44% diagnosed after they reached 18 years old. There were 68% of female patients and 32% male patients. Pulmonary hypertension severity distribution was mild (52%), moderate (26%), and severe (22%). The most diagnosed acyanotic CHD was ASD. The defect size in acyanotic CHD was mostly large, and mostly found in female patients. The severity of pulmonary hypertension was mostly mild.

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