A Modified Form of Low-Density Lipoprotein with Increased Electronegative Charge is Present in Rheumatoid Arthritis Synovial Fluid

1997 ◽  
Vol 22 (4) ◽  
pp. 705-710 ◽  
Author(s):  
Letian Dai ◽  
Zhi Zhang ◽  
Paul G Winyard ◽  
Karl Gaffney ◽  
Hugh Jones ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Rheumatoid Arthritis Synovial Fluid

Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients

2000 ◽  
Vol 32 (6) ◽  
pp. 479-486 ◽  
Author(s):  
L. Dai ◽  
D.J. Lamb ◽  
D.S. Leake ◽  
M.L. Kus ◽  
H.W. Jones ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidised Low Density Lipoprotein

Association of Polymorphisms Modulating Low-density Lipoprotein Cholesterol with Susceptibility, Severity, and Progression of Rheumatoid Arthritis

2013 ◽  
Vol 40 (6) ◽  
pp. 798-808 ◽  
Author(s):  
Yune-Jung Park ◽  
Seung-Ah Yoo ◽  
Susanna Choi ◽  
Hee-Soo Yoo ◽  
Ho-Sung Yoon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factor ◽  
Radiographic Progression ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Nucleotide Polymorphisms ◽  
Radiographic Severity ◽  
Genotype Score

Objective.Dyslipidemia, a risk factor for cardiovascular diseases, is more prevalent in patients with rheumatoid arthritis (RA) than in the general population. We investigated whether single-nucleotide polymorphisms (SNP) modulating low-density lipoprotein (LDL) cholesterol affect susceptibility, severity, and progression of RA.Methods.We enrolled 302 patients with RA and 1636 healthy controls, and investigated the SNP modulating LDL cholesterol. Clinical characteristics of RA, serum adipocytokine concentrations, and radiographic severity were analyzed according to genotype score based on the number of unfavorable alleles. The influence of genotype score on radiographic progression was also investigated using multivariable logistic models.Results.We identified 3 SNP (rs688, rs693, and rs4420638) modulating LDL cholesterol in Koreans, which correlated well with LDL cholesterol levels in both patients with RA and controls. Among them, 2 SNP, rs688 and rs4420638, were more prevalent in patients with RA than in controls. In patients with RA carrying more unfavorable alleles (genotype score ≥ 3), disease activity measures, serum adipocytokine levels, and radiographic severity were all increased. The genotype score was an independent risk factor for radiographic progression of RA over 2 years, and its effect was greater than the influence of conventional risk factors.Conclusion.SNP modulating LDL cholesterol influence the risk, activity, and severity of RA. These results provide the first evidence that genetic mechanisms linked to dyslipidemia may directly contribute to the susceptibility and prognosis of RA, a representative of chronic inflammatory diseases, explaining the high incidence of dyslipidemia in RA.

Low density lipoprotein of synovial fluid in inflammatory joint disease is mildly oxidized

Lipids ◽  
1998 ◽  
Vol 33 (11) ◽  
pp. 1115-1121 ◽  
Author(s):  
M. J. James ◽  
D. van Reyk ◽  
K. A. Rye ◽  
R. T. Dean ◽  
L. G. Cleland ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Joint Disease ◽  
Low Density ◽  
Inflammatory Joint Disease

scholarly journals Lipoprotein Subclasses Determined by Nuclear Magnetic Resonance Spectroscopy and Coronary Atherosclerosis in Patients with Rheumatoid Arthritis

2010 ◽  
Vol 37 (8) ◽  
pp. 1633-1638 ◽  
Author(s):  
CECILIA P. CHUNG ◽  
ANNETTE OESER ◽  
PAOLO RAGGI ◽  
TUULIKKI SOKKA ◽  
THEODORE PINCUS ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Nuclear Magnetic Resonance ◽  
Coronary Artery ◽  
Disease Activity ◽  
Coronary Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Resonance Spectroscopy ◽  
Low Density ◽  
Lipoprotein Subclasses

Objective.Patients with rheumatoid arthritis (RA) are at increased risk of atherosclerosis, but routine lipid measurements differ little from those of people without RA. We examined the hypothesis that lipid subclasses determined by nuclear magnetic resonance spectroscopy (NMR) differed in patients with RA compared to controls and are associated with disease activity and the presence of coronary-artery atherosclerosis.Methods.We measured lipoprotein subclasses by NMR in 139 patients with RA and 75 control subjects. Lipoproteins were classified as large low-density lipoprotein (LDL; diameter range 21.2–27.0 nm), small LDL (18.0–21.2 nm), large high-density lipoprotein (HDL; 8.2–13.0 nm), small HDL (7.3–8.2 nm), and total very low-density lipoprotein (VLDL; ≥ 27 nm). All subjects underwent an interview and examination; disease activity was quantified by the 28-joint Disease Activity Score (DAS28) and coronary artery calcification (CAC) was measured with electron-beam computed tomography.Results.Concentrations of small HDL particles were lower in patients with RA (18.2 ± 5.4 nmol/l) than controls (20.0 ± 4.4 nmol/l; p = 0.003). In patients with RA, small HDL concentrations were inversely associated with DAS28 (rho = −0.18, p = 0.04) and C-reactive protein (rho = −0.25, p = 0.004). Concentrations of small HDL were lower in patients with coronary calcification (17.4 ± 4.8 nmol/l) than in those without (19.0 ± 5.8 nmol/l; p = 0.03). This relationship remained significant after adjustment for the Framingham risk score and DAS28 (p = 0.025). Concentrations of small LDL particles were lower in patients with RA (1390 ± 722 nmol/l) than in controls (1518 ± 654 nmol/l; p = 0.05), but did not correlate with DAS28 or CAC.Conclusion.Low concentrations of small HDL particles may contribute to increased coronary atherosclerosis in patients with RA.

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