scholarly journals Effects of low-dose epinephrine infusion on cardiovascular and renal responses to water immersion in humans

1996 ◽  
Vol 9 (9) ◽  
pp. 902-908 ◽  
Author(s):  
H Kruse
Keyword(s):  
Low Dose ◽  
Water Immersion ◽  
Epinephrine Infusion ◽  
Renal Responses

The effect of low dose epinephrine infusion on hepatic hemodynamics

1998 ◽  
Vol 30 (5) ◽  
pp. 2306-2308 ◽  
Author(s):  
J.W Marsh ◽  
J.G Drougas ◽  
J.K Wright ◽  
W.C Chapman ◽  
Y.T Becker ◽  
...  
Keyword(s):  
Low Dose ◽  
Epinephrine Infusion ◽  
Hepatic Hemodynamics

Interaction of ANP with endothelin on cardiovascular, renal, and endocrine function

1992 ◽  
Vol 262 (2) ◽  
pp. E135-E141 ◽  
Author(s):  
K. Ota ◽  
T. Kimura ◽  
M. Shoji ◽  
M. Inoue ◽  
K. Sato ◽  
...  
Keyword(s):  
Low Dose ◽  
Renal Plasma Flow ◽  
Peripheral Resistance ◽  
Plasma Renin ◽  
Endocrine Function ◽  
Molar Ratio ◽  
High Dose ◽  
Anesthetized Dogs ◽  
Induced Changes ◽  
Renal Responses

To assess the interaction of endothelin (ET) with atrial natriuretic peptide (ANP) on cardiovascular and renal function, arginine vasopressin (AVP) release, and the renin-angiotensin-aldosterone system, either a low or high dose of ET (4 or 12 pmol.kg-1.min-1) was administered with ANP (26 pmol.kg-1.min-1) for 45 min after the initial infusion of ANP alone in anesthetized dogs. In the other groups, either ANP or saline alone was administered for 90 min. ANP alone decreased blood pressure (BP), cardiac output (CO), plasma aldosterone, and plasma renin activity (PRA), increased urinary Na and K excretion (UNaV and UKV, respectively) and urine flow (UF), but did not affect plasma AVP. The low dose of ET had no effect on these ANP-induced changes. However, the high dose of ET curtailed the responses to ANP, increased BP and PRA, and decreased UNaV, UKV, and UF associated with decreased renal plasma flow and glomerular filtration rate. High ET also further potentiated the decrease in CO and the increase in total peripheral resistance induced by ANP and increased plasma AVP. These results indicate that a dose of ET one-half that of ANP (on the molar ratio) may have completely counteracted vascular, hormonal, and renal responses to ANP.

Plasma volume, fluid shifts, and renal responses in humans during 12 h of head-out water immersion

1992 ◽  
Vol 73 (2) ◽  
pp. 539-544 ◽  
Author(s):  
L. B. Johansen ◽  
N. Foldager ◽  
C. Stadeager ◽  
M. S. Kristensen ◽  
P. Bie ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Plasma Volume ◽  
Evans Blue ◽  
Body Fluid ◽  
Water Immersion ◽  
Time Control ◽  
Fluid Shifts ◽  
And Control ◽  
Renal Responses ◽  
Measurable Change

Changes in plasma volume (PV) throughout 12 h of thermoneutral (34.5 degrees C) water immersion (WI) were evaluated in eight subjects by an improved Evans blue (EB) technique and by measurements of hematocrit (Hct), hemoglobin (Hb), and plasma protein concentrations (Pprot). Appropriate time control studies (n = 6) showed no measurable change in PV. At 30 min of immersion, EB measurements demonstrated an increase in PV of 16 +/- 2% (457 +/- 70 ml). Calculations, however, based on concomitant changes in Hct, Hb, and Pprot showed an increase in PV of only 6.9 +/- 0.9 to 10.0 +/- 0.8% at 30 min of WI. PV values based on EB measurements subsequently declined throughout WI to (but not below) the preimmersion level. Concomitantly, changes in PV calculated from Pprot values remained increased, whereas estimations of changes in PV based on Hct and Hb values returned to prestudy levels after 4 h of immersion. It is concluded that PV initially increases by 16 +/- 2% during WI and does not decline below preimmersion and control levels during 12 h of immersion despite a loss of 0.9 +/- 0.2 liter of body fluid. Furthermore, changes in Hct, Hb, and Pprot do not provide accurate measures of the changes in PV during WI in humans.

Hyper-responsiveness to low-dose epinephrine infusion in mild essential hypertension

1988 ◽  
Vol 6 (4) ◽  
pp. S581-583 ◽  
Author(s):  
Sverre E. Kjeldsen ◽  
Ingrid Os ◽  
Arne Westheim ◽  
Knut Lande ◽  
Knut Gjesdal ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Low Dose ◽  
Epinephrine Infusion

scholarly journals Renal hemodynamic and excretory responses to intra-arterial infusion of peroxynitrite in anesthetized rats

2009 ◽  
Vol 296 (1) ◽  
pp. F170-F176 ◽  
Author(s):  
Luis C. Matavelli ◽  
Philip J. Kadowitz ◽  
L. Gabriel Navar ◽  
Dewan S. A. Majid
Keyword(s):  
Low Dose ◽  
No Synthase ◽  
High Concentration ◽  
Arterial Infusion ◽  
Anesthetized Rats ◽  
Low Concentrations ◽  
Nos Inhibitor ◽  
Renal Responses ◽  
Higher Doses

Peroxynitrite (ONOO−) is formed endogenously by the reaction of nitric oxide (NO) and superoxide (O2−). To examine the hypothesis that OONO− cause renal vasodilation at low concentrations but cause vasoconstriction at higher concentrations, we examined renal responses to intra-arterial infusion of incremental doses of OONO− (10, 20, and 40 μg·kg−1·min−1; 45 min each) in anesthetized rats. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by PAH and inulin clearance. In control rats ( n = 6), low dose (10 μg·kg−1·min−1) of OONO− increased RBF by 10 ± 3% and GFR by 15 ± 5%. The higher doses (20 and 40 μg·kg−1·min−1) mostly reversed these responses which were −7 ± 4 and −27 ± 7% ( P < 0.05) in RBF and −0.1 ± 4.8 and −14 ± 12% in GFR, respectively. There were no appreciable changes in urine flow (V) and sodium excretion (UNaV) during OONO− infusion. However, in rats pretreated with NO synthase (NOS) inhibitor, l-NAME (50 μg·kg−1·min−1; n = 5), these doses of ONOO− significantly reduced RBF (−26 ± 7, −27 ± 6, and −44 ± 3%) and GFR (−21 ± 6, −25 ± 8, and −32 ± 12%) with variable increases in V or UNaV. Long-term infusion of OONO− (10 μg·kg−1·min−1 for 75 min) in another set of control rats ( n = 5) also showed similar vasodilator and hyperfiltration responses. These data indicate that ONOO− acts as an oxidant at high concentration but provides renoprotective function at low concentration that depends on intact NOS activity.

Low-dose epinephrine infusion in inadvertent hypothermia prevention during surgery

2008 ◽  
Vol 25 (Sup 44) ◽  
pp. 53
Author(s):  
K. Lebedinskiy ◽  
S. Parvanian ◽  
A. Nikolayev
Keyword(s):  
Low Dose ◽  
Epinephrine Infusion

Initial renal responses of nonhuman primate to immersion and intravascular volume expansion

1980 ◽  
Vol 48 (2) ◽  
pp. 243-248 ◽  
Author(s):  
T. V. Peterson ◽  
J. P. Gilmore ◽  
I. H. Zucker
Keyword(s):  
Nonhuman Primate ◽  
Volume Expansion ◽  
Diastolic Pressure ◽  
Renal Plasma Flow ◽  
Water Immersion ◽  
Venous Pressure ◽  
Left Ventricular ◽  
Water Excretion ◽  
Arterial Blood ◽  
Renal Responses

Experiments were performed in anesthetized Macaca fascicularis monkeys to determine if the initial renal responses of these animals to head-out vertical water immersion and isoncotic, isotonic volume expansion are similar, especially with regard to the onset of any changes in solute or water excretion. Significant increases in urine flow, sodium excretion, and osmolar clearance occurred after 10 min of immersion but not until 30 min after volume expansion. Potassium excretion increased during immersion but decreased after volume expansion. Mean arterial blood pressure increased after 30 min of immersion but was unchanged after volume expansion. Indices of vascular filling, central venous pressure in the immersed animals and left ventricular end-diastolic pressure in the volume-expanded animals, increased immediately after the intervention. Effective renal plasma flow increased in both groups but glomerular filtration rate was not consistently elevated. These results suggest that, in the nonhuman primate, immersion and volume expansion exert their renal effects through different afferent and/or efferent mechanisms and should not be considered as similar volume stimuli.

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