Poster #M168 DNA METHYLATION OF THE 5-HT1A RECEPTOR GENE PROMOTER IS ASSOCIATED WITH NEGATIVE SYMPTOM RESPONSE TO ANTIPSYCHOTIC DRUG TREATMENT

2014 ◽  
Vol 153 ◽  
pp. S251-S252
Author(s):  
Gavin Reynolds ◽  
Caroline Dalton ◽  
Hao Tang
Keyword(s):  
Dna Methylation ◽  
Drug Treatment ◽  
Antipsychotic Drug ◽  
Negative Symptom ◽  
Receptor Gene ◽  
Gene Promoter ◽  
Symptom Response ◽  
Antipsychotic Drug Treatment

Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset

2012 ◽  
Vol 26 (6) ◽  
pp. 2712-2718 ◽  
Author(s):  
Philippe A. Melas ◽  
Maria Rogdaki ◽  
Urban Ösby ◽  
Martin Schalling ◽  
Catharina Lavebratt ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Drug Treatment ◽  
Antipsychotic Drug ◽  
Disease Onset ◽  
Global Dna Methylation ◽  
Antipsychotic Drug Treatment

Post-Mortem Antipsychotic Drug Concentrations and Unexplained Deaths

1994 ◽  
Vol 165 (6) ◽  
pp. 787-791 ◽  
Author(s):  
Nedzara Jusic ◽  
Malcolm Lader
Keyword(s):  
Drug Treatment ◽  
Antipsychotic Drug ◽  
Drug Regimen ◽  
The Body ◽  
Electrolyte Balance ◽  
Post Mortem ◽  
Unexpected Death ◽  
Legal Cases ◽  
Drug Concentrations ◽  
Antipsychotic Drug Treatment

BackgroundThe relationship between antipsychotic drug treatment and sudden unexplained death remains unclear. The estimation of post-mortem blood drug concentrations should be helpful.MethodEight medico-legal cases were reviewed with respect to behaviour of patient, type and dosage of drug treatment, mode of death, post-mortem findings and drug concentrations.ResultsThe problems of evaluating such drug levels are discussed. Five of the eight patients had probably toxic concentrations of antipsychotic and/or antidepressants, which caused death, usually involving cardiac arrhythmias.ConclusionsIn cases of sudden unexpected death, a sample of blood from a peripheral vein should be obtained immediately death is pronounced or the body discovered, and sent for analysis. To minimise such fatalities, the patient should be monitored carefully, with ECG if feasible, and electrolyte balance checked. The drug regimen used should be kept simple and large doses of antipsychotics and/or antidepressants avoided wherever possible.

scholarly journals Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in Iceland

2017 ◽  
Vol 71 (7) ◽  
pp. 496-502 ◽  
Author(s):  
Oddur Ingimarsson ◽  
James H. MacCabe ◽  
Magnús Haraldsson ◽  
Halldóra Jónsdóttir ◽  
Engilbert Sigurdsson
Keyword(s):  
Drug Treatment ◽  
Antipsychotic Drug ◽  
Antipsychotic Drug Treatment
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