22P BCL2 Negative Breast Tumors but not Axillary Lymph Nodes Predict a Better Overall Survival in Patients Treated with Higher Doses of Epirubicin at a Median follow-up of 15.6 Years

Abstract Background: Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases remain controversial. This meta-analysis aimed to evaluate the prognostic significance of occult lymph node metastases in breast cancer.Methods: Studies published published until May, 2020, which retrospectively examined negative lymph nodes by step sectioning and/or immunohistochemistry, were retrieved from MEDLINE, EMBASE, CNKI, and Cochrane Library. The pooled Relative risk (RR) with 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS) were calculated to appraise the associations between occult metastases and prognosis.Results: The results showed patients with occult metastases in axillary lymph nodes had poorer five-year DFS (RR = 0.930; 95% CI = 0.907–0.954) and OS (RR = 0.972; 95% CI = 0.954–0.990). Furthermore, the DFS (RR = 0.887; 95% CI = 0.810–0.972) and OS (RR = 0.896; 95% CI = 0.856–0.939) of patients with occult metastases were much lower after a ten-year follow-up.Conclusions: Occult metastases in the axillary lymph nodes of patients with breast cancer are associated with poorer disease-free and overall survival. Occult metastases might serve as a predictive factor of survival outcomes in patients with breast cancer.

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Adjuvant chemotherapy with ac versus high dose mitoxantrone, cyclophosphamide (MC). filgrastrlm in operable breast cancer involving 10 or more axillary lymph nodes: 3 years follow-up result

European Journal of Cancer ◽

10.1016/s0959-8049(97)84762-4 ◽

1997 ◽

Vol 33 ◽

pp. S81

Author(s):

P. Fumoleau ◽

F. Chauvln ◽

M. Namer ◽

R. Bugat ◽

M. Tublana-Hulin ◽

...

Keyword(s):

Breast Cancer ◽

Adjuvant Chemotherapy ◽

Lymph Nodes ◽

Operable Breast Cancer ◽

Axillary Lymph Nodes ◽

High Dose ◽

Axillary Lymph

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Occult Metastases in Axillary Lymph Nodes as a Predictor of Survival in Node-Negative Breast Carcinoma with Long-term Follow-up

The Breast Journal ◽

10.1111/j.1075-122x.2004.21328.x ◽

2004 ◽

Vol 10 (3) ◽

pp. 174-180 ◽

Cited By ~ 34

Author(s):

Wenche Reed ◽

Per J. Bohler ◽

Berit Sandstad ◽

Jahn M. Nesland

Keyword(s):

Breast Carcinoma ◽

Lymph Nodes ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Node Negative ◽

Occult Metastases ◽

Long Term Follow Up

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Breast Tumors: Immunoglobulins in Axillary Lymph Nodes

Tumori Journal ◽

10.1177/030089168607200606 ◽

1986 ◽

Vol 72 (6) ◽

pp. 575-579 ◽

Cited By ~ 2

Author(s):

Mariano Urdiales-Viedma ◽

Francisco Nogales-Fernandez ◽

Sebastian Martos-Padilla ◽

Emilio Sanchez-Cantalejo

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Breast Tumors ◽

Lymphoid Cells ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Lymphoid Follicles ◽

Node Metastases ◽

High Histologic Grade

The immnuohistochemical determination of immunoglobulins IgA, IgG and IgM in axillary lymph nodes from 50 unselected breast ductal carcinomas disclosed that lymph nodes with IgG-positive lymphoid follicles and/or metastasized lymph nodes with IgM-positive lymphoid cells are statistically related to breast tumors with a high histologic grade and more than 3 lymph node metastases.

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