CAPOPUS Trial: an Observer-blinded RCT of Specialized Addiction Treatment Versus Standard Treatment for Young Patients with Cannabis Abuse and Psychosis

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
M. Nordentoft ◽  
C. Hjorthøj ◽  
A. Fohlmann
Keyword(s):  
Motivational Interviewing ◽  
Group Treatment ◽  
Addiction Treatment ◽  
Psychotic Disorders ◽  
Outcome Measurement ◽  
Young Patients ◽  
Community Treatment ◽  
List Type ◽  
Treatment As Usual ◽  
Cannabis Abuse

Background:A number of studies indicate a link between cannabis-use and psychosis as well as more severe psychosis in those with existing psychotic disorders. There is currently insufficient evidence to decide the optimal way to treat cannabis abuse among patients with psychosis.Objectives:The major objective for the CapOpus trial is to evaluate the effects of a specialized addiction treatment program adding group treatment and motivational interviewing to treatment as usual compared with just treatment as usual.Design:The trial is designed as a randomized, parallel-group, observer-blinded clinical trial. Patients are recruited through teams for early detection of people with psychosis, community mental health centers, and assertive community treatment teams. Patients are randomized to one of two treatment arms, both lasting six months:1.specialized addiction treatment plus treatment as usual or2.treatment as usual.The specialized addiction treatment is manualized and consists of both individual and group-based motivational interviewing and cognitive behavioral therapy, and incorporates both the family and the case-manager of the patient.The primary outcome measurement will be amount of reduction in cannabis consumption. other outcome measures will be improvements in psychosis symptoms, cognitive functioning, quality of life and social functioning, and cost-benefit of the treatments.

Early intervention program for psychosis: Experience and results in a mental health center

2011 ◽  
Vol 26 (S2) ◽  
pp. 1163-1163
Author(s):  
M.C. Campos Mangas ◽  
M.A. Ruiz Feliu
Keyword(s):  
Early Intervention ◽  
Young People ◽  
Psychotic Disorder ◽  
Intervention Program ◽  
Psychotic Disorders ◽  
Mental Health Center ◽  
Community Treatment ◽  
Initial Assessment ◽  
Psychotic Symptoms ◽  
List Type

IntroductionThis program aims to assist young people aged 16 to 35 years at risk for or who have a severe mental disorder, a psychosis both affected and unaffected, according to the principles of early intervention and assertive community treatment.ObjectivesAssisting young people with psychosis in order to achieve symptomatic and functional recovery, return to provide standardized environment and prevent deterioration.MethodsInitial assessment is made and individualized plan of work.Inclusion criteria1.Diagnosis: substance-induced psychotic disorder, schizophrenia and other psychotic disorders, bipolar disorder and mood disorders with psychotic symptoms2.age: 16–35 years3.Informed consentEvaluation ToolsPANSS, SCIP, CDS, CGI-S, PAS, CAN, EU, SFS, GAF, WHOQUOL-BREF, IEQ-EU, UKU, HoNOS, CGI-IP, CGI-ICResultsThe sample consisted of 22 patients. 45.5% men and 54.5% women. Mean age 24 (SD = 4.74). Diagnosis: schizophrenia 54.5%, 27.3% acute psychotic disorder, 4.5% and 13.6% schizoaffective disorder manic episode with psychotic symptoms. Clinical stage at the beginning of the program: 45.5% stage 2, 4.5% stage 3a; 22.7% stage 3b, 3c stage 22.7% and 4.5% stage 4.ConclusionsIt is necessary to implement such programs to establish the treatment as soon as possible to the onset of the disease and improve prognosis.

scholarly journals Cognitive-behavioural therapy for substance use disorders in people with psychotic disorders

2006 ◽  
Vol 188 (5) ◽  
pp. 439-448 ◽  
Author(s):  
Amanda Baker ◽  
Sandra Bucci ◽  
Terry J. Lewin ◽  
Frances Kay-Lambkin ◽  
Paul M. Constable ◽  
...  
Keyword(s):  
Substance Use ◽  
Motivational Interviewing ◽  
Cognitive Behavioural Therapy ◽  
Psychotic Disorders ◽  
Community Sample ◽  
Behavioural Therapy ◽  
Treatment As Usual ◽  
Cognitive Behavioural ◽  
General Functioning ◽  
Amphetamine Use

BackgroundFew randomised controlled trials have been aimed specifically at substance use reduction among people with psychotic disorders.AimsTo investigate whether a 10-session intervention consisting of motivational interviewing and cognitive-behavioural therapy (CBT) was more efficacious than routine treatment in reducing substance use and improving symptomatology and general functioning.MethodA community sample of people with a psychotic disorder and who reported hazardous alcohol, cannabis and/or amphetamine use during the preceding month was recruited. Participants were randomly allocated to motivational interviewing/CBT (n=65) or treatment as usual (n=65), and were assessed on multiple outcomes at baseline, 15 weeks, 6 months and 12 months.ResultsThere was a short-term improvement in depression and a similar trend with regard to cannabis use among participants who received the motivational interviewing/CBT intervention, together with effects on general functioning at 12 months. There was no differential benefit of the intervention on substance use at 12 months, except for a potentially clinically important effect on amphetamine use.ConclusionsThe motivational interviewing/CBT intervention was associated with modest improvements.

scholarly journals Psychological and psychosocial interventions for negative symptoms in psychosis: Systematic review and meta-analysis

2017 ◽  
Vol 210 (5) ◽  
pp. 324-332 ◽  
Author(s):  
Danyael Lutgens ◽  
Genevieve Gariepy ◽  
Ashok Malla
Keyword(s):  
Systematic Review ◽  
Negative Symptoms ◽  
Psychotic Disorders ◽  
Meta Analysis ◽  
Psychosocial Interventions ◽  
Detailed Examination ◽  
Behavioural Therapy ◽  
Integrated Treatment ◽  
Treatment As Usual

BackgroundNegative symptoms observed in patients with psychotic disorders undermine quality of life and functioning. Antipsychotic medications have a limited impact. Psychological and psychosocial interventions, with medication, are recommended. However, evidence for the effectiveness of specific non-biological interventions warrants detailed examination.AimsTo conduct a meta-analytic and systematic review of the literature on the effectiveness of non-biological treatments for negative symptoms in psychotic disorders.MethodWe searched for randomised controlled studies of psychological and psychosocial interventions in psychotic disorders that reported outcome on negative symptoms. Standardised mean differences (SMDs) in values of negative symptoms at the end of treatment were calculated across study domains as the main outcome measure.ResultsA total of 95 studies met our criteria and 72 had complete quantitative data. Compared with treatment as usual cognitive–behavioural therapy (pooled SMD −0.34, 95% CI −0.55 to −0.12), skills-based training (pooled SMD −0.44, 95% CI −0.77 to −0.10), exercise (pooled SMD −0.36, 95% CI −0.71 to −0.01), and music treatments (pooled SMD −0.58, 95% CI −0.82 to −0.33) provide significant benefit. Integrated treatment models are effective for early psychosis (SMD −0.38, 95% CI −0.53 to −0.22) as long as the patients remain in treatment. Overall quality of evidence was moderate with a high level of heterogeneity.ConclusionsSpecific psychological and psychosocial interventions have utility in ameliorating negative symptoms in psychosis and should be included in the treatment of negative symptoms. However, more effective treatments for negative symptoms need to be developed.

scholarly journals High Incidence and Prevalence of Drug-Related Movement Disorders in Young Patients With Psychotic Disorders

2017 ◽  
Vol 37 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Thierry Q. Mentzel ◽  
Ritsaert Lieverse ◽  
Oswald Bloemen ◽  
Wolfgang Viechtbauer ◽  
Peter N. van Harten
Keyword(s):  
Movement Disorders ◽  
Psychotic Disorders ◽  
Young Patients ◽  
High Incidence

scholarly journals Comprehensive Clinical and Social Research at the Moscow Research Institute of Psychiatry: Translation into Clinical Practice

10.17816/cp95 ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 45-52
Author(s):  
Alexander B. Shmukler ◽  
Larisa G. Movina ◽  
Oleg O. Papsuev ◽  
Lyudmila I. Salnikova ◽  
Nina G. Shashkova ◽  
...  
Keyword(s):  
Russian Federation ◽  
Psychotic Disorders ◽  
Psychiatric Care ◽  
Medical Rehabilitation ◽  
Community Treatment ◽  
Psychotic Episode ◽  
Organizational Forms ◽  
New Organizational Forms ◽  
The Russian Federation ◽  
Research Institute

The article is devoted to the work of the Moscow Research Institute of Psychiatry to improve psychiatric care for patients with psychotic disorders. An important feature of this work was an integrated approach, in which the clinical picture of the disease was assessed in close connection with the patient's personal and psychological characteristics, social conditions of his life, therapeutic opportunities, rehabilitation potential and organizational structure of care. The article reflects the results of many years of work of the department of outpatient psychiatry and the organization of psychiatric care under the guidance of Professor I.Ya. Gurovich. The results of scientific research carried out by the staff of the institute in a traditional humanistic manner are presented. The translational nature of the research is emphasized by its inextricable link with clinical and social approaches. As a result of many years of work, a concept was developed to provide assistance to various groups of patients, starting with the first manifestations of the disease and ending with cases of long-term chronic disorders with a pronounced level of social maladaptation. As a result, a whole spectrum of new organizational forms of psychiatric care was proposed, such as departments (clinics) of the first psychotic episode, medical rehabilitation departments, assertive community treatment departments, designed for the most difficult patients. These organizational forms were fixed in the regulatory documents of the Ministry of Health and Social Development of the Russian Federation. To date, the above departments have been established in psychiatric institutions in many regions of the Russian Federation. Further development of this area is associated with neurobiological research to identify complex biomarkers of psychotic spectrum disorders. Thus, the research carried out at the present time preserves the tradition of an integrated clinical and social approach to the study of mental disorders. It is shown that an important advantage of this approach is their translational nature.

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