PW01-148 - Effective connectivity within the network of fearful facial affect recognition in patients with bipolar disorder compared to healthy controls

2010 ◽  
Vol 25 ◽  
pp. 1564 ◽  
Author(s):  
M. Kempton ◽  
D. Dima ◽  
J. Roiser ◽  
K. Stephan ◽  
K. Friston ◽  
...  
2003 ◽  
Vol 9 (4) ◽  
pp. 623-632 ◽  
Author(s):  
GLEN E. GETZ ◽  
PAULA K. SHEAR ◽  
STEPHEN M. STRAKOWSKI

Patients diagnosed with bipolar disorder (BPD), by definition, have problems with emotional regulation. However, it remains uncertain whether these patients are also deficient at processing other people's emotions, particularly while manic. The present study examined the ability of 25 manic bipolar patients and 25 healthy participants on tasks of facial recognition and facial affect recognition at three different presentation durations: 500 ms, 750 ms, and 1000 ms. The groups did not differ in terms of age, education, sex, ethnicity, or estimated IQ. The groups did not differ significantly on either a novel computerized facial recognition task or the Benton Facial Recognition Test. In contrast, the bipolar group performed significantly more poorly than did the comparison group on a novel facial affect labeling task. Although the patient group had slower reaction times on all 3 computerized tasks, the presentation duration did not have an effect on performance in the patients. This study suggests that patients with bipolar disorder are able to recognize faces, but have difficulty processing facial affective cues. (JINS, 2003, 9, 623–632.)


2014 ◽  
Vol 152 (2-3) ◽  
pp. 440-445 ◽  
Author(s):  
Nursen Yalcin-Siedentopf ◽  
Christine M. Hoertnagl ◽  
Falko Biedermann ◽  
Susanne Baumgartner ◽  
Eberhard A. Deisenhammer ◽  
...  

2021 ◽  
Vol 10 (9) ◽  
pp. 1904
Author(s):  
Nora I. Muros ◽  
Arturo S. García ◽  
Cristina Forner ◽  
Pablo López-Arcas ◽  
Guillermo Lahera ◽  
...  

People with schizophrenia have difficulty recognizing the emotions in the facial expressions of others, which affects their social interaction and functioning in the community. Static stimuli such as photographs have been used traditionally to examine deficiencies in the recognition of emotions in patients with schizophrenia, which has been criticized by some authors for lacking the dynamism that real facial stimuli have. With the aim of overcoming these drawbacks, in recent years, the creation and validation of virtual humans has been developed. This work presents the results of a study that evaluated facial recognition of emotions through a new set of dynamic virtual humans previously designed by the research team, in patients diagnosed of schizophrenia. The study included 56 stable patients, compared with 56 healthy controls. Our results showed that patients with schizophrenia present a deficit in facial affect recognition, compared to healthy controls (average hit rate 71.6% for patients vs 90.0% for controls). Facial expressions with greater dynamism (compared to less dynamic ones), as well as those presented from frontal view (compared to profile view) were better recognized in both groups. Regarding clinical and sociodemographic variables, the number of hospitalizations throughout life did not correlate with recognition rates. There was also no correlation between functioning or quality of life and recognition. A trend showed a reduction in the emotional recognition rate as a result of increases in Positive and Negative Syndrome Scale (PANSS), being statistically significant for negative PANSS. Patients presented a learning effect during the progression of the task, slightly greater in comparison to the control group. This finding is relevant when designing training interventions for people with schizophrenia. Maintaining the attention of patients and getting them to improve in the proposed tasks is a challenge for today’s psychiatry.


2010 ◽  
Vol 117 (2-3) ◽  
pp. 523-524
Author(s):  
Nursen Yalcin ◽  
Alex Hofer ◽  
Susanne Baumgartner ◽  
Cord Benecke ◽  
Falko Biedermann ◽  
...  

2008 ◽  
Vol 192 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Jigar Jogia ◽  
Morgan Haldane ◽  
Annabel Cobb ◽  
Veena Kumari ◽  
Sophia Frangou

BackgroundBipolar disorder is associated with dysfunction in prefrontal and limbic areas implicated in emotional processing.AimsTo explore whether lamotrigine monotherapy may exert its action by improving the function of the neural network involved in emotional processing.MethodWe used functional magnetic resonance imaging to examine changes in brain activation during a sad facial affect recognition task in 12 stable patients with bipolar disorder when medication-free compared with healthy controls and after 12 weeks of lamotrigine monotherapy.ResultsAt baseline, compared with controls, patients with bipolar disorder showed overactivity in temporal regions and underactivity in the dorsal medial and right ventrolateral prefrontal cortex, and the dorsal cingulate gyrus. Following lamotrigine monotherapy, patients demonstrated reduced temporal and increased prefrontal activation.ConclusionsThis preliminary evidence suggests that lamotrigine may enhance the function of the neural circuitry involved in affect recognition.


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