Sulpiride adjunction to clozapine in treatment-resistant schizophrenic patients: a preliminary case series study

1997 ◽  
Vol 12 (3) ◽  
pp. 152-155 ◽  
Author(s):  
R Shiloh ◽  
Z Zemishlany ◽  
D Aizenberg ◽  
A Weizman
Keyword(s):  
Negative Symptoms ◽  
Case Series ◽  
Treatment Resistant ◽  
Case Series Study ◽  
Schizophrenic Patients ◽  
Chronic Neuroleptic ◽  
Series Study ◽  
Remarkable Reduction ◽  
Positive And Negative Symptoms

SummarySix chronic neuroleptic-resistant schizophrenic patients, partial responders to clozapine, were co-administered 600 mg/day of sulpiride (a selective D2 dopaminergic antagonist) as an augmentation to clozapine (a relatively weak D2 blocker), for 10 weeks, open-labeled. A remarkable reduction in positive and negative symptoms was observed in four of the six patients.

scholarly journals Efficacy of milnacipran in treating anxiety symptoms in schizophrenic patients receiving clozapine: a case series study

2006 ◽  
Vol 28 (4) ◽  
pp. 339-340 ◽  
Author(s):  
Clarissa Severino Gama ◽  
Vanessa Cassina Zanatto ◽  
Felipe Picon ◽  
Maria Inês Lobato ◽  
Paulo Silva Belmonte-de-Abreu
Keyword(s):  
Case Series ◽  
Anxiety Symptoms ◽  
Case Series Study ◽  
Schizophrenic Patients ◽  
Series Study

The usage of new antipsychotics in treatment of schizophrenia with obsessive-compulsive symptoms

2011 ◽  
Vol 26 (S2) ◽  
pp. 1490-1490
Author(s):  
I. Reznik ◽  
S. Yadin ◽  
A. Weizman
Keyword(s):  
Case Series ◽  
Therapeutic Modality ◽  
Complex Nature ◽  
Obsessive Compulsive ◽  
Case Series Study ◽  
Schizophrenic Patients ◽  
Large Case Series ◽  
Series Study ◽  
New Antipsychotics ◽  
Large Case

BackgroundObsessive-compulsive (OC) symptoms have been observed in a substantial proportion of schizophrenic patients. Different etiopathological origins of OC symptoms make this type of schizophrenia to be a heterogeneous entity in phenomenological as well as in therapeutic aspects. The complex nature of the treatment response in this group of schizophrenic patients is as yet unclear.MethodsWe present a large case series study describes our experience with clozapine, risperidone, olanzapine, quetiapine, ziprazidone, amisulpiride, sertindole and paliperidone as a sole agents and in combination with serotonin reuptake inhibitors (SRIs) in patients with OCD-schizophrenia (n = 55) and schizo-obsessive disorder (n = 64).ResultsIn patients with OCD-schizophrenia treatment with atypicals (other than clozapine), the better results (significant reduction of OC as well as schizophrenia symptoms) were achieved in combination with SRIs, while olanzapine showed the fastest overall improvement. In schizo-obsessive patients, treatment with atypicals (including clozapine) as monotherapy was the better therapeutic modality, and the risperidone showed the best results. Quetiapine, amisulpiride, sertindole, paliperidone and ziprazidone (as sole agents and with SRIs) were shown as approximately equal in their antipsychotic and antiobsessive activity and overall safety.ConclusionsThe effects of different atypicals (with/without SRIs) on psychotic and OC symptoms are vary, probably due to different origin of OC symptoms. We suggest that:1) schizo-obsessive patients might be successfully treated with atypicals alone;2) in OCD-schizophrenia atypicals monotherapy may be less efficient, and in some cases may worsen OC symptoms, so it should be treated concomitantly with SRIs. Further investigations are needed to substantiate our observations.

scholarly journals Efficacy of milnacipran in treating anxiety symptoms in schizophrenic patients receiving clozapine: a case series study]]>

2006 ◽  
Vol 28 (4) ◽  
Author(s):  
Clarissa S. Gama ◽  
Vanessa C. Zanatto ◽  
Felipe Picon ◽  
Maria I. Lobato ◽  
Paulo S. Belmonte-de-Abreu
Keyword(s):  
Case Series ◽  
Anxiety Symptoms ◽  
Case Series Study ◽  
Schizophrenic Patients ◽  
Series Study

The Safety and Efficacy of Clozapine in Severe Treatment-Resistant Schizophrenic Patients in the UK

1993 ◽  
Vol 163 (2) ◽  
pp. 150-154 ◽  
Author(s):  
C. E. Adams ◽  
T. R. E. Barnes ◽  
M. A. Essali ◽  
S. R. Hirsch ◽  
A. V. P. MacKay ◽  
...  
Keyword(s):  
Adverse Event ◽  
Side Effects ◽  
Negative Symptoms ◽  
Extrapyramidal Side Effects ◽  
Treatment Resistant ◽  
Frequent Adverse Event ◽  
Safety And Efficacy ◽  
Schizophrenic Patients ◽  
The Uk ◽  
Positive And Negative Symptoms

In order to assess the safety and some efficacy aspects of clozapine under UK conditions, 54 in-patients with severe treatment-resistant schizophrenic disorders were evaluated using several scales before and during treatment. Of the 54 evaluated, 26 completed the 26-week study. Of these patients, 20 showed improvement in psychopathology, often to a marked degree, involving both positive and negative symptoms. Some oral-facial extrapyramidal side-effects decreased as well. Two patients developed neutropenia, but recovered on discontinuation of clozapine. The most frequent adverse event was hypersalivation, and five patients suffered from seizures. It is concluded that clozapine is worth considering for the treatment of severe treatment-resistant patients in the UK.

Evaluating Vitality and Periodontal Sensitivity of Teeth Adjacent to the Site of Open Sinus Lift Surgery before and after Treatment: A Case Series Study

2020 ◽  
Vol 30 (2) ◽  
pp. 77-81
Author(s):  
Amir Moeintaghavi ◽  
Negar Azami ◽  
Mohammad Sadegh Zohrevand ◽  
Farid Shiezadeh ◽  
Hamid Jafarzadeh ◽  
...  
Keyword(s):  
Case Series ◽  
Sinus Lift ◽  
Case Series Study ◽  
Before And After ◽  
Series Study

Perfil microbiológico en los pacientes con diagnóstico de sinusitis nosocomial hospitalizados en la Unidad de Cuidados Intensivos del Hospital de San José durante el período de Febrero de 2013 a Marzo de 2015. Microbiological profile in patients diagnosed with nosocomial sinusitis hospitalized in the Intensive Care Unit of the Hospital of San Jose during the period February 2013 to March 2015.

2018 ◽  
Vol 45 (4) ◽  
pp. 261-266
Author(s):  
Jorge Luis Alfredo Herrera Ariza ◽  
Mario Alejandro Villabón ◽  
Ángela Carolina Rojas Ruiz ◽  
Iván Fernando Moncada
Keyword(s):  
Disease Control ◽  
Maxillary Sinus ◽  
Case Series ◽  
San Jose ◽  
Study Materials ◽  
Case Series Study ◽  
Nosocomial Sinusitis ◽  
Centers For Disease Control ◽  
Microbial Agents ◽  
Series Study

Objetivo: Determinar los agentes microbianos más frecuentes en pacientes de UCI con diagnóstico de sinusitis nosocomial en el Hospital de San José, período de dos años. Diseño: Estudio observacional tipo serie de casos. Materiales y métodos: Se incluyeron pacientes mayores de 18 años con una estancia hospitalaria mayor a 48 horas, que desarrollaron sinusitis nosocomial de acuerdo a los criterios de los Centers for Disease Control (CDC). Uso de dos técnicas: punción y lavado de seno maxilar. Resultados: 19 pacientes que cumplen los criterios de sinusitis nosocomial. Edad promedio 55 años, predominio sexo masculino. El 94.7% tuvo sonda orogástrica, 89.5% intubación orotraqueal y 89.5% ventilación mecánica. Hubo aislamiento polimicrobiano de gram positivos, gram negativos, anaerobios y hongos. La mortalidad en UCI fue 32%. Conclusiones: Se presenta una adecuada sensibilidad al tratamiento con vancomicina y piperacilina tazobactam en esta patología. El rendimiento diagnóstico es igual al realizar lavado y punción del seno maxilar.Objetive: To determine the microbial agents on UCI patients who have beendiagnosed with nosocomial sinusitis at the San Jose Hospital, (Bogota, Colombia) in a two-year period. Design: Case series study. Materials and methods: Patients who were older than 18-year olds, with a hospitalization longer than 48 hours who developed nosocomial sinusitis, according to the criteria established by the Centers for Disease Control (CDC) were included. Two techniques were employed for data collection: puncture and maxillary sinus wash. Results: 19 patients fulfill the criteria requirements for nosocomial sinusitis. Average age was 55 years old. Population mostly was composed by male individuals. 94.7% had a gastric tube intervention; 89.5% had tracheal intubation 89.5% mechanical ventilation. Polymicrobial isolation with gram positive, gram negative, anaerobic and fungi were identified. Mortality in critical care unites was 32%. Conclusions: An adequate sensitivity to treatment with vancomycin and piperacillin tazobactam was evidenced in this pathology.To perform a washing or maxillary sinus puncture had the same efficiency fordiagnosing this disease.

Sign in / Sign up

Export Citation Format

Share Document